Docetaxel-Encapsulating Small-Sized Polymeric Micelles with Higher Permeability and Its Efficacy on the Orthotopic Transplantation Model of Pancreatic Ductal Adenocarcinoma

Li, Yunfei; Li, Peiran; Jin, Mingji; Jiang, Changgao; Gao, Zhonggao

doi:10.3390/ijms151223571

Cited by 8 publications

(9 citation statements)

References 33 publications

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“…presented a similar approach for the fabrication of PEG ‐b‐ PDLLA small‐sized polymeric micelles with maleimide functional handles, which were subsequently conjugated to TAT peptides. Their in vitro and in vivo studies showed effectiveness and permeation higher than or similar to unfunctionalized cargo‐containing micelles …”

Section: Functional Handles On Polymersomes and Nanoparticlesmentioning

confidence: 99%

“…Their in vitro and in vivo studies showed effectiveness and permeation higher than or similar to unfunctionalized cargo-containing micelles. [71] Polymers which undergo topological transformations via macromolecular metamorphosis by using reversible-covalent reactive handles, capable of forming new covalent bonds in situ have been coined by Sumerlin et al. A thermodynamically selective cycloaddition between maleimide and anthracene or furan functionalized polymers allowed for metamorphosis of linear amphiphilic block-copolymers and hyperbranced polymers.…”

Section: Diels-alder and Thiol Conjugationmentioning

confidence: 99%

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Designing Molecular Building Blocks for Functional Polymersomes

Rijpkema

Toebes

Maas

et al. 2019

Israel Journal of Chemistry

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In recent years various polymeric vesicles have been reported that show promising results for drug delivery applications, nanomotors and/or nanoreactors. These polymeric vesicles can be assembled from many different materials and various coupling reactions have been applied for functionalization of the vesicles. However, the designs reported are still rather simple, as it is challenging to mimic biological complex systems. In this review we focus on the properties of widely used hydrophobic polymers to better understand polymersome properties for various applications. Examples are shown of how researchers have used and modulated block‐copolymers and their properties to their advantage. Furthermore, an overview of possible end group functionalizations of nanoparticles is reported, giving insight in recent developments of smart nanoparticles for biomedical applications.

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Section: Functional Handles On Polymersomes and Nanoparticlesmentioning

confidence: 99%

Section: Diels-alder and Thiol Conjugationmentioning

confidence: 99%

Designing Molecular Building Blocks for Functional Polymersomes

Rijpkema

Toebes

Maas

et al. 2019

Israel Journal of Chemistry

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“…As for the TAT-PECL, the characteristic resonance of maleimide at 6.68 ppm disappeared, indicating the successful conjugation of TAT to Mal-PECL (Figure S2b, Supporting Information). [24] Besides, the appearance of the peak at 1.84 ppm in 1 H NMR of DA-TAT-PECL indicated the complete amidation of TAT amines by DA (Figure S2c, Supporting Information). [10] The signals of hydrogen protons adjacent to difsulfide bond in (CPT) 2 -ss appeared at 2.83 ppm and 4.02 ppm, while transferred to 3.08 ppm and 4.41 ppm after reaction with 2,3-dibromomaleimide (Figure S2d,e, Supporting Information).…”

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confidence: 99%

Dimeric Drug Polymeric Micelles with Acid‐Active Tumor Targeting and FRET‐Traceable Drug Release

et al. 2017

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Trans-activating transcriptional activator (TAT), a cell-penetrating peptide, is extensively used for facilitating cellular uptake and nuclear targeting of drug delivery systems. However, the positively charged TAT peptide strongly interacts with serum components and undergoes substantial phagocytosis by the reticuloendothelial system, causing a short blood circulation in vivo. In this work, an acid-active tumor targeting nanoplatform DA-TAT-PECL is developed to inhibit the nonspecific interactions of TAT in the bloodstream. 2,3-dimethylmaleic anhydride (DA) is used to convert the TAT's amines to carboxylic acid; the resulting DA-TAT is conjugated to poly(ethylene glycol)-poly(ε-caprolactone) (PEG-PCL, PECL) to get DA-TAT-PECL. After self-assembly into polymeric micelles, they are capable of circulating in the physiological condition for a long time and promoting cell penetration upon accumulation at the tumor site and deshielding the DA group. Moreover, camptothecin (CPT) is used as the anticancer drug and modified into a dimer (CPT) -ss-Mal, in which two CPT molecules are connected by a reduction-labile maleimide thioether bond. The Förster resonance energy transfer signal between CPT and maleimide thioether bond is monitored to visualize the drug release process, and effective targeted delivery of antitumor drugs is demonstrated. This pH/reduction dual-responsive micelle system provides a new platform for high fidelity cancer therapy.

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“…Loading capacity was defined as the percentage of DTX by weight in the freeze-dried nanoparticles, and encapsulation efficiency was defined as the percentage of DTX by weight incorporated in the nanoparticles compared with the initial weight of DTX (26). Both were determined by high performance liquid chromatography (HPLC) (27).…”

Section: Methodsmentioning

confidence: 99%

A comparative study on the effect of docetaxel-albumin nanoparticles and docetaxel-loaded PEG-albumin nanoparticles against non-small cell lung cancer

Gao¹,

Jin²,

Yin³

et al. 2015

International Journal of Oncology

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Abstract. The present study mainly compared the effect of docetaxel-albumin nanoparticles (DANPs) and docetaxelloaded PEG-albumin nanoparticles (PEG-DANPs) against non-small cell lung cancer (NSCLC). We made systematic assessments on these three drugs against NSCLC both in vitro and in vivo. With the purpose of eliminating side-effects of the commercial formulation (Tween-80) and prolonging the blood circulation time, we used emulsion-evaporation crosslink method to prepare DANPs and PEG-DANPs. The DANPs had an average particle size of 163.4±3.76 nm, a zeta potential of -19.4±0.18 mV, a polydispersity index of 0.143±0.03, a drug loading of 8.71±0.98%, and an encapsulation efficiency of 93.58±0.86%; the average particle size of PEG-DANPs is 169.19±2.36 nm, zeta potential is -18.2±0.21 mV, with a polydispersity index of 1.56±0.05, a drug loading of 8.72±1.05% and an encapsulation efficiency of 95.4±5.5%. PEG-DANPs showed a dose-and time-dependent efficacy in cytotoxicity studies in vitro; the hemolysis test indicated that PEG-DANPs had less hemocytolysis than Aisu ® and DANPs; in addition, a more prolonged circulation time and sustained in vitro release behavior were observed in the PEG-DANPs compared with Aisu ® and DANPs; the cellular uptake test in vitro demonstrated that PEG-DANPs could be absorbed easier into the nucleus; furthermore, the tumor growth of NSCLC-bearing nude mice in vivo was reduced the most by PEG-DANPs. In conclusion, the PEG-DANPs have the lowest side-effects, the highest antitumor activity with the longest blood circulation time of the three drugs, and it will provide an alternative to patients with NSCLC. IntroductionLung cancer is a very common malignant tumor with incidence and mortality rates the first worldwide, almost one million patients are diagnosed with lung cancer each year all over the world. NSCLC accounts for 75-85% among the total number of lung cancer, and elderly patients aged >65 years accounted for >50% (1). It is always at the late stage when patients were discovered (stage III or IV) and the 5-year survival rate is only 12-15% (2,3), thus, these patients cannot receive surgical treatment (4,5).For elderly advanced NSCLC patients, chemotherapy is still the first choice of treatment (6,7), it is a relatively effective treatment for elderly NSCLC patients who cannot tolerant surgical operation. It can effectively reduce the progress of lung cancer and the recurrence, enhance the effect of clinical treatment, prolong patient survival rate and improve their quality of life (8).There are some chemotherapy regimens and drugs for elderly NSCLC patients, such as cisplatin, VP-16, gemcitabine, paclitaxel and docetaxel (9). However, there is lack of a mature and effective way for NSCLC because most of the elderly patients refuse or are unable to complete the treatment. So how to choose a drug with good effect and little side reaction is a hot spot in tumor research (10,11). Docetaxel is a cell cycle specific antitumor drug which is applied to cells at the M phase. It is a relative...

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Docetaxel-Encapsulating Small-Sized Polymeric Micelles with Higher Permeability and Its Efficacy on the Orthotopic Transplantation Model of Pancreatic Ductal Adenocarcinoma

Cited by 8 publications

References 33 publications

Designing Molecular Building Blocks for Functional Polymersomes

Designing Molecular Building Blocks for Functional Polymersomes

Dimeric Drug Polymeric Micelles with Acid‐Active Tumor Targeting and FRET‐Traceable Drug Release

A comparative study on the effect of docetaxel-albumin nanoparticles and docetaxel-loaded PEG-albumin nanoparticles against non-small cell lung cancer

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