Do we Need to Screen Uremic Patients for Toxoplasmosis before Kidney Transplantation?

Abstract

Background: Toxoplasmosis can cause serious complications among persons with weakened immune systems and therefore in solid organ transplant patients. Objectives: The aim of the study was to evaluate the value of screening for toxoplasma antibody titers in the donors and recipients candidate for renal transplantation in Ahvaz city, Iran. Materials and Methods: In a cross sectional study from March 2010 to April 2012, we evaluated donors and recipients who referred to our kidney transplant center in Naft Hospital, Ahwaz, Iran.Routine pre transplante laboratory testes including liver function and toxoplasma IgG and IgM antibody were performed. Results: A total of 52 people, 30 donors (20 male and 10 Female) and 22 recipients (12 male and 10 female) were included in the study. Mean age of donors and recipients were 30.32 ± 6.75 years and 45.09 ± 10.57 years respectively. The marker of HBV and HCV infection were negative in 100% of recipients and donors. Toxoplasma IgG antibody was positive in 45.45 percent of recipients (N = 10) and 63.33 percent of donors (N = 19) but there was no statistically significant difference between them (P = 0 .057) and between males and females (P = 0.74). Toxoplasma IgM antibody was negative in 100 percent of recipients (N = 22) and 93.33 percent of donors (N = 28). Conclusions: According to seropositivity for toxoplasma infection in about half of donors and recipients candidate for kidney transplantation, we should perform screening for this infection to avoid kidney donation from seropositive donor to seronegative recipient.

Herpes Group Viruses: a Seroprevalence Study in Hemodialysis Patients

“…Th e present study found no signifi cant diff erence in herpes group virus seroprevalence between genders, which is similar to the results of many other studies conducted in hemodialysis patients [23][24][25] . However, a slightly higher CMV seroprevalence in women was noted in some studies 26 , whereas a Sudanese study has reported a slightly higher seroprevalence in men (97.9% vs. 93.3%) 27 .…”

“…A study conducted from 2005 to 2008 showed 100% EBV seropositivity in both potential renal transplant donors and transplant recipients 22 . A more recently published study (2011) showed a higher, although not statistically signifi cant diff erence in EBV IgG seroprevalence between re-transplant patients (70%) and kidney donors (52%) 23 .…”

The frequency of Epstein-Barr virus among hemodialysis patients, Ahvaz, Iran

“…Our results were consistent with recent studies. In study conducted by Beladi Mousavi, EBV IgG antibody was positive in 70% of recipients and 52% of donors but there was no statistically significant difference between males and females (p=0.94) (22). The present study found no significant difference in EBV IgG antibody seroprevalence between genders, which is similar to the result of study conducted by Beladi Mousavi among hemodialysis patients.…”

Kajian Serologi Toksoplasmosis dalam Kalangan Penerima Transplan Renal di Hospital Kuala Lumpur

“…Dengan adanya ujian saringan, kumpulan yang berisiko tinggi boleh dikenal pasti terutamanya mereka yang terdiri daripada penerima seronegatif dan penderma seropositif serta kaedah diagnosis yang sesuai berdasarkan serokonversi boleh dikenal pasti (Wulf et al 2005). Selain itu, terapi profilaksis juga perlu diambil oleh pesakit sebelum dan selepas menjalani transplantasi organ untuk mengelakkan berlakunya jangkitan atau reaktivasi T. gondii dan seterusnya boleh mengurangkan komplikasi teruk akibat toksoplasmosis (Beladi Mousavi & Faramarzi 2013;Izadi et al 2013;Martina et al 2011).…”