Do we need PD‐L1 as a biomarker for thyroid cytologic and histologic specimens?

Abstract

This editorial introduces the study by Dell’Aquila and colleagues in this edition of Cancer, which suggests that Programmed death‐ligand 1 (PD‐L1) expression in the thyroid gland and on thyroid liquid‐based cytology might represent a marker of malignancy that correlates with papillary thyroid carcinoma, but not with noninvasive follicular thyroid neoplasm with papillary‐like nuclear features, and discusses the potential use of PD‐L1 for thyroid lesions.

PD‐L1 and PD‐1 expression in thyroid follicular epithelial dysplasia: Hashimoto thyroiditis related atypia and potential papillary carcinoma precursor

“…The father of modern pathology Rudolf Virchow already in 1863 proposed a link between inflammation and cancer when observed the presence of inflammatory cells in neoplasms [3][4][5]. In 1909, Ehrlich suggested the idea on continuous cancer cell mutation with immune system scan and eradication [6].…”