Do we need Green Analytical Chemistry?

Koel, Mihkel

doi:10.1039/c5gc02156a

Cited by 111 publications

(37 citation statements)

References 37 publications

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“…Among many factors that look decisive for the development of this field is the synthetic accessibility of these systems. Generally, it is highly desirable that these scaffolds originated from a simple, clean and easy synthetic route which also aligns well with the current idea of "green analytical chemistry (GAC)" [17][18][19][20][21][22]. Moreover, methods that ensure high degree of structural and functional diversity are an added advantage in studying structure property relationships (SPRs).…”

Section: Introductionmentioning

confidence: 92%

Optical and electrochemical dual channel sensing of Cu2+ using functionalized furo[2,3-d]pyrimidines-2,4[1H,3H]-diones

Kumar

Kumawat

Bhatt

et al. 2017

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Owing to their easy accessibility and high degree of structural and functional diversity, many multicomponent reactions (MCRs) have been a rich source of conjugate π-systems, functionalised chromophores (or fluorophore) and redox active molecules. Despite their high explorative potential and practical benefits, only a few MCR products have been so far investigated for their metal sensing abilities. In the present report, two furopyrimidinones (FPys) based molecular systems have been synthesized by [4+1] cycloaddition based MCR sequence. Designed chemosensors displayed optic (absorption spectra) as well as electroanalytical (ion selective electrode) response toward Cu ion in solution and membrane phase respectively (dual channel sensing). Different aspects of both the sensing phenomena such as selectivity, association constants, detection limit, membrane composition etc. were studied in detail using UV-Vis spectroscopy, NMR titration and cell assembly. Both the compounds showed excellent performance characteristics such as high selectivity, acceptable affinity and low detection limits (10M) in both sensing assays with potential utility in the area of sample monitoring.

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Section: Introductionmentioning

confidence: 92%

Optical and electrochemical dual channel sensing of Cu2+ using functionalized furo[2,3-d]pyrimidines-2,4[1H,3H]-diones

Kumar

Kumawat

Bhatt

et al. 2017

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…The current comfortable situation has led to some limitations in the possibilities of separations in HPLC. This situation is deepened by the fact that many regulating agencies require the employment of validated methods which include ACN as a mandatory mobile phase component [7]. From the growing environmental awareness that led to the emergence of the so-called Bgreen chemistry,^new research has emerged to find replacements to ACN [8], especially because it is an undesirable solvent from a sustainable point of view [9,10].…”

Section: Introductionmentioning

confidence: 99%

Natural deep eutectic solvents as the major mobile phase components in high-performance liquid chromatography—searching for alternatives to organic solvents

et al. 2018

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Over the past six decades, acetonitrile (ACN) has been the most employed organic modifier in reversed-phase high-performance liquid chromatography (RP-HPLC), followed by methanol (MeOH). However, from the growing environmental awareness that leads to the emergence of "green analytical chemistry," new research has emerged that includes finding replacements to problematic ACN because of its low sustainability. Deep eutectic solvents (DES) can be produced from an almost infinite possible combinations of compounds, while being a "greener" alternative to organic solvents in HPLC, especially those prepared from natural compounds called natural DES (NADES). In this work, the use of three NADES as the main organic component in RP-HPLC, rather than simply an additive, was explored and compared to the common organic solvents ACN and MeOH but additionally to the greener ethanol for separating two different mixtures of compounds, one demonstrating the elution of compounds with increasing hydrophobicity and the other comparing molecules of different functionality and molar mass. To utilize NADES as an organic modifier and overcome their high viscosity monolithic columns, temperatures at 50 °C and 5% ethanol in the mobile phase were used. NADES are shown to give chromatographic performances in between those observed for ACN and MeOH when eluotropic strength, resolution, and peak capacity were taken into consideration, while being less environmentally impactful as shown by the HPLC-Environmental Assessment Tool (HPLC-EAT) metric. With the development of proper technologies, DES could open a new class of mobile phases increasing the possibilities of new separation selectivities while reducing the environmental impact of HPLC analyses. Graphical abstract Natural deep eutectic solvents versus traditional solvents in HPLC.

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“…There are few tools to evaluate analytical procedures in terms of meeting the requirements of green analytical chemistry. Eco-Scale is one such tool [ 33 , 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Two Methods for the Determination of Selected Pesticides in Honey and Honeybee Samples

2018

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Developed and validated analytical methods for the determination of a wide spectrum of pesticide residues in honey and honeybee samples after the modification of QuEChERS extraction in combination with gas chromatography–tandem quadrupole mass spectrometry (GC-MS/MS) and liquid chromatography–tandem quadrupole mass spectrometry (LC-MS/MS) were discussed and compared. The developed methods were evaluated regarding the utilized equipment and reagents using Eco-Scale and compared in terms of extraction time, accuracy, precision, sensitivity and versatility, with similar procedures. The results proved that the QuEChERS protocol in combination with LC and GC techniques fulfills the requirements of green analytical chemistry, so it can be used as a tool in environmental monitoring. The recovery was 85–116% for honey and 85.5–103.5% for honeybee samples. The developed methods were successfully applied in monitoring real samples collected from three districts of Pomerania in Poland. Analysis of real samples revealed the presence of the following pesticides: bifenthrin, fenpyroximate, methidathione, spinosad, thiamethoxam, triazophos, metconazole and cypermethrin at levels higher than the MRLs established by the EU.

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Do we need Green Analytical Chemistry?

Abstract: There is very strong opinion that Green Analytical Chemistry is needed beside so-called common Analytical Chemistry. However, the developments in Analytical Chemistry must lead to environmentally safe, economical and cost-effective methods on the whole.

Cited by 111 publications

References 37 publications

Optical and electrochemical dual channel sensing of Cu2+ using functionalized furo[2,3-d]pyrimidines-2,4[1H,3H]-diones

Optical and electrochemical dual channel sensing of Cu2+ using functionalized furo[2,3-d]pyrimidines-2,4[1H,3H]-diones

Natural deep eutectic solvents as the major mobile phase components in high-performance liquid chromatography—searching for alternatives to organic solvents

Comparison of Two Methods for the Determination of Selected Pesticides in Honey and Honeybee Samples

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