Do toxic heavy metals affect antioxidant defense mechanisms in humans?

Wieloch, Monika; Kamiński, Piotr; Ossowska, A.; Koim-Puchowska, Beata; Stuczyński, Tomasz; Kuligowska-Prusińska, Magdalena; Dymek, Grazyna; Mańkowska, Aneta; Odrowąż-Sypniewska, Grażyna

doi:10.1016/j.ecoenv.2011.11.017

Cited by 33 publications

(19 citation statements)

References 64 publications

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“…It was argued that the observed increase in CAT activity represented a defense mechanism against increased H 2 O 2 levels during lead-induced OS. Wieloch et al ( 2012 ) found the same results regarding SOD activity in case subjects living in a polluted area and reported that this increase occurred due to health conditions and environmental characteristics. Therefore, elevated SOD activity was considered as an antioxidant defense against environmental stress.…”

Section: Types and Utility Of Biomarkerssupporting

confidence: 77%

“…Two studies verifi ed elevated SOD activity in the study groups when compared with the controls (Ahamed et al 2008 ;Wieloch et al 2012 ), and 4 studies found no significant changes in SOD activity with raised BLLs (Jin et al 2006 ;Diouf et al 2006 ;Martinez et al 2013 ;Wu et al 2013 ). CAT activity was also signifi cantly higher in participants with higher BLLs in 3 studies (Ahamed et al 2006(Ahamed et al , 2008(Ahamed et al , 2011 but was substantially lower in subjects with higher BLLs in 1 study (Wieloch et al 2012 ).…”

Section: Tablementioning

confidence: 88%

“…CAT activity was also signifi cantly higher in participants with higher BLLs in 3 studies (Ahamed et al 2006(Ahamed et al , 2008(Ahamed et al , 2011 but was substantially lower in subjects with higher BLLs in 1 study (Wieloch et al 2012 ).…”

Section: Tablementioning

confidence: 90%

“…Almeida Lopes et al case groups in which participants had not been diagnosed with a disease (2.36 ± 2.7 μg/dL; Table 3 ) (Wieloch et al 2012 ). The most frequently used biomarkers for Pb-induced OS were as follows: GSH (Siddiqui et al 2002 ;Ahamed et al 2006Ahamed et al , 2008Ahamed et al , 2011Diouf et al 2006 ;Jin et al 2006 ;Cabral et al 2012 ), MDA (Siddiqui et al 2002 ;Ahamed et al 2006Ahamed et al , 2008Ahamed et al , 2011Jin et al 2006 ;Cabral et al 2012 ;Wu et al 2013 ), SOD (Jin et al 2006 ;Diouf et al 2006 ;Ahamed et al 2008 ;Martinez et al 2013 ;Wieloch et al 2012 ;Wu et al 2013 ), CAT (Ahamed et al 2006(Ahamed et al , 2008(Ahamed et al , 2011Wieloch et al 2012 ;Martinez et al 2013 ), and GPx (Diouf et al 2006 ;Jin et al 2006 ;Ahamed et al 2008 ) (Table 3 ).…”

Section: Tablementioning

confidence: 97%

“…Several studies have shown that the effect of lead on antioxidant enzymes and other components of the antioxidant system, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and reduced glutathione (GSH), depends on the level of lead to which the subjects are exposed. These divergent results have been observed in general and in occupationally exposed populations (Kasperczyk et al 2004a ;Ahamed et al 2008 ;Mohammad et al 2008 ;Kasperczyk et al 2009 ;Grover et al 2010 ;Wieloch et al 2012 ). Malondialdehyde (MDA) and thiobarbituric acid-reactive substances (TBARS) are products of lipid peroxidation (LPO) that can occur in the presence of lead.…”

Section: Introductionmentioning

confidence: 96%

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Lead Exposure and Oxidative Stress: A Systematic Review

Lopes

Peixe

Mesas³

et al. 2016

Reviews of Environmental Contamination and Toxicology

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Lead is an environmental toxicant that can induce oxidative stress (OS) via reactive oxygen species (ROS) generation, which has been reported as an important mechanism underlying lead toxicity (Gurer and Ercal 2000; Pande and Flora 2002; Kasperczyk et al. 2004a; Farmand et al. 2005; Verstraeten et al. 2008; Wang et al. 2009; Martinez-Haro et al. 2011). OS occurs when the generation of ROS exceeds the antioxidant system's ability to defend cells against oxidized molecules. ROS is a term generally used to refer to free radicals derived from O2 (e.g., superoxide anions [O2-] and hydroxyl radicals [OH-]) or to non-radical species (e.g. hydrogen peroxide [H2O2]) (Halliwell and Cross 1994).

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Section: Types and Utility Of Biomarkerssupporting

confidence: 77%

Section: Tablementioning

confidence: 88%

Section: Tablementioning

confidence: 90%

Section: Tablementioning

confidence: 97%

Section: Introductionmentioning

confidence: 96%

See 3 more Smart Citations

Lead Exposure and Oxidative Stress: A Systematic Review

Lopes

Peixe

Mesas³

et al. 2016

Reviews of Environmental Contamination and Toxicology

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Occupational cadmium exposure‐associated oxidative stress and erythrocyte fragility among jewelry workers in India

Moitra

Brashier²,

Sahu

2014

American J Industrial Med

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Protective role of silymarin against manganese‐induced nephrotoxicity and oxidative stress in rat

Chtourou

Garoui

Boudawara

et al. 2013

Environmental Toxicology

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Metal toxicity may occur after exposure from many sources. Oxidative stress is thought to be involved in manganese-induced toxicity and leads to various health disorders. Silymarin (SIL), a natural flavonoid, has been reported to have many benefits and medicinal properties. The aim of this study was to assess the toxicity of manganese (Mn) on oxidative stress and DNA damage in the kidney of rats and its alleviation by SIL. Manganese was given orally in drinking water (20 mg MnCl2 /mL) with or without SIL administration (100 mg /kg intraperitoneally) for 30 days. Our data showed that SIL significantly prevented Mn induced nephrotoxicity, indicated by both diagnostic indicators of kidney injury like plasma urea, uric acid and creatinine and urinary electrolyte levels and by histopathological analysis. Moreover, Mn-induced profound elevation of the production of reactive oxygen species (ROS) and altered the levels of oxidative stress related biomarkers in kidney tissue. This is evidenced by the increase of lipid peroxidation, protein carbonylation, DNA fragmentation and urinary hydrogen peroxide, while, the activities of enzymatic antioxidant and glutathione level were decreased. Treatment with SIL reduced the alterations in the renal and urine markers, decreasing lipid peroxidation markers, increasing the antioxidant cascade and decreasing the Mn-induced damage. All these changes were supported by histopathological observations. These findings suggested that the inhibition of Mn-induced damage by SIL was due at least in part to its antioxidant activity and its capacity to modulate the oxidative damage.

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Do toxic heavy metals affect antioxidant defense mechanisms in humans?

Cited by 33 publications

References 64 publications

Lead Exposure and Oxidative Stress: A Systematic Review

Lead Exposure and Oxidative Stress: A Systematic Review

Occupational cadmium exposure‐associated oxidative stress and erythrocyte fragility among jewelry workers in India

Protective role of silymarin against manganese‐induced nephrotoxicity and oxidative stress in rat

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