Do tissue damage biomarkers used to assess machine-perfused NHBD kidneys predict long-term renal function post-transplant?

Gok, Muhammed A.; Pelzers, Maurice; Glatz, Jan F. C.; Shenton, B. K.; Buckley, P.; Peaston, R; Cornell, Christopher; Mantle, D; Soomro, Naeem; Jaques, Bryon; Manas, Derek; Talbot, David

doi:10.1016/j.cccn.2003.07.023

Cited by 40 publications

(27 citation statements)

References 21 publications

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“…In general, PP of kidneys is considered to function through stabilization of the organ by supplying nutrients and oxygen during storage, by decreasing intrarenal vasospasm and by removal of waste materials while mimicking circulation and increasing vascular compliance. Numerous diagnostic procedures and perfusate modifications have been introduced for PP throughout its evolution (21)(22)(23)(24)(25). Despite the abundance of literature examining these issues and novel technical methodologies, opinions regarding the ultimate efficacy of PP are mixed.…”

Section: Introductionmentioning

confidence: 99%

Are We Frozen in Time? Analysis of the Utilization and Efficacy of Pulsatile Perfusion in Renal Transplantation

Schold

Kaplan

Howard

et al. 2005

American Journal of Transplantation

146

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Preservation techniques are crucial to deceased donor kidney transplantation (DDTx), but the efficacy of pulsatile perfusion (PP) versus cold storage (CS) remains uncertain. We describe patterns of PP use and explore four fundamental questions. What kidneys are selected for PP? How does PP affect utilization of donated kidneys? What effect does PP have on outcomes? When does PP appear to be most efficacious? We examined rates of PP in DDTx in the United States from 1994 to 2003. We generated models for organ utilization, delayed graft function (DGF) and for the use of PP. We analyzed the long-term effect of PP with multivariate Cox models. The utilization rates for nonexpanded criteria donors (ECDs) were similar by storage type, but for ECDs there was a significantly higher utilization rate with PP (70% with PP vs. 59% with CS, p < 0.001). Use of PP was widely variable across transplant centers. DGF rates were significantly lower with PP (27.6% vs. 19.6%). PP was associated with a mild benefit on death censored graft survival (adjusted hazard ratio = 0.88, 95% CI 0.85-0.91). Reduced DGF and significantly lower discard rates of ECDs associated with PP suggest an important utility of PP in renal transplantation. Additional evidence of improvement in graft survival, particularly in more recent years, provides further encouraging evidence for the use of PP.

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Section: Introductionmentioning

confidence: 99%

Are We Frozen in Time? Analysis of the Utilization and Efficacy of Pulsatile Perfusion in Renal Transplantation

Schold

Kaplan

Howard

et al. 2005

American Journal of Transplantation

146

View full text Add to dashboard Cite

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“…None were predictive of graft survival [20]. Gok et al found similar results for GST levels and graft survival [29]. PFI therefore appears unique in its ability to predict survival, however this needs to be validated in a second cohort.…”

Section: Discussionmentioning

confidence: 91%

Ex Vivo Perfusion Characteristics of Donation After Cardiac Death Kidneys Predict Long-Term Graft Survival

Sevinc¹,

Stamp

Carter

et al. 2016

Transplantation Proceedings

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“…In this context, the evaluation of non-invasive kidney injury biomarkers from perfusate solution could add a greater predictive value to kidney viability and allograft outcomes as concede assessment at multiple time points during preservation. Moers et al (47) have investigated for the first time six important perfusate biomarkers that have been supported in different studies and are already in use by various transplant centres (48)(49)(50)(51)(52). These biomarkers are; lactate dehydrogenase (LDH), aspartate aminotransferase (ASAT), total glutathione-S-transferase (GST), alanine-aminopeptidase (Ala-AP), N-acetyl-β-Dglucosaminidase (NAG), and heart type fatty acid binding protein (H-FABP).…”

Section: Perfusate Biomarkersmentioning

confidence: 99%

Pre-transplant biomarkers and prediction of post-transplant outcomes in kidney transplantation

Salvadori¹,

Tsalouchos²

2017

J Renal Inj Prev

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New findings in "omics" and genomics allowed us to find out new robust biomarkers that may allow a diagnosis avoiding invasive and dangerous procedures. This could be of particular importance if applied on transplant clinical practice. In kidney transplantation several pre-transplant biomarkers revealed useful either for a better renal allocation and as predictive of future outcomes as delayed graft function, rejections and long term outcome. Different biomarkers have been recently described bringing interesting results regarding predictive outcomes in the field of kidney transplantation. In this setting, an evaluation for pre-transplant biomarkers especially in the era of expanded criteria donors (ECDs) and non-heart-beating donors (NHBDs) could help transplant physicians to make decisions on allocation or even on discharge of the allograft. Furthermore, identify pre-transplant biomarkers is useful for a risk stratification of delayed graft function (DGF), acute rejection (AR) episodes and chronic allograft dysfunction (CAD) after kidney transplantation (KT). In this review, we report recent findings on pre-transplant biomarkers from various biological samples from donors or recipients. Please cite this paper as:

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Do tissue damage biomarkers used to assess machine-perfused NHBD kidneys predict long-term renal function post-transplant?

Cited by 40 publications

References 21 publications

Are We Frozen in Time? Analysis of the Utilization and Efficacy of Pulsatile Perfusion in Renal Transplantation

Are We Frozen in Time? Analysis of the Utilization and Efficacy of Pulsatile Perfusion in Renal Transplantation

Ex Vivo Perfusion Characteristics of Donation After Cardiac Death Kidneys Predict Long-Term Graft Survival

Pre-transplant biomarkers and prediction of post-transplant outcomes in kidney transplantation

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