Do Thiazides Prevent Recurrent Idiopathic Renal Calcium Stones?

Brocks, P; Dahl, Claus; Wolf, Hans; Transbøl, Ib

doi:10.1016/s0140-6736(81)90302-0

Cited by 107 publications

(42 citation statements)

References 4 publications

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“…Seven of the ten RCTs reported a reduction in recurrence rate in treated patients (9 -12,14 -16). Two trials that showed no difference in outcome were limited by their short follow-up duration of Ͻ2 years (17,18). A consistent finding in these trials is that stone-forma-tion rate between treated and control groups did not begin to diverge until after at least 1 year of therapy.…”

Section: Thiazide Diuretics and Nephrolithiasismentioning

confidence: 92%

The Evidence-Based Use of Thiazide Diuretics in Hypertension and Nephrolithiasis

Reilly¹,

Peixoto²,

Desir³

2010

Clinical Journal of the American Society of Nephrology

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Thiazide-type diuretics are commonly used in the treatment of hypertension and nephrolithiasis. Evidence from randomized clinical trials needs to be considered in decisions about agent choice and dose. In nephrolithiasis, one of the major limitations of the literature is a paucity of data on the dose-response effect of hydrochlorothiazide (HCTZ) on urinary calcium excretion. The best available evidence for prevention of stone recurrence suggests the use of indapamide at 2.5 mg/d, chlorthalidone at 25 to 50 mg daily, or HCTZ 25 mg twice a day or 50 mg daily. In hypertension, chlorthalidone (12.5 to 30 mg daily) may be the best choice when a diuretic is used for initial therapy, with indapamide (1.5 mg daily) being a valuable alternative for older patients. When adding a thiazide to other drug classes, indapamide (2.5 mg daily) has demonstrated value in hypertensive patients who have had a stroke, and HCTZ (12.5 to 25 mg daily) has a safe track record in several patient groups. Although chlorthalidone has not been tested as add-on therapy, the authors believe it is a safe option in such cases.

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Section: Thiazide Diuretics and Nephrolithiasismentioning

confidence: 92%

The Evidence-Based Use of Thiazide Diuretics in Hypertension and Nephrolithiasis

Reilly¹,

Peixoto²,

Desir³

2010

Clinical Journal of the American Society of Nephrology

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“…Stone specific diagnostic and therapeutic algorithms Figure 2 [31][32][33][34][35][36][37][38][39][40][41][42][43][44]. Elevated levels of ionized calcium in serum (or total calcium and albumin) require assessment of intact PTH to confirm or exclude suspected hyperparathyroidism (HPT) [60].…”

Section: 3mentioning

confidence: 99%

Metabolic Evaluation and Recurrence Prevention for Urinary Stone Patients: EAU Guidelines

Skolarikos¹,

Straub²,

Knoll³

et al. 2015

European Urology

284

199

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“…There are two placebocontrolled studies with thiazides [45,46], several others with control groups, and follow-up studies of patients with no comparable controls [47][48][49][50][51][52][53][54][55]. In one of the randomized studies thiazide was given together with magnesium and this regimen tended to be more effective than when thiazides were given alone [38].…”

Section: Thiazidementioning

confidence: 99%

Epidemiology and medical management of stone disease

2003

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SUMMARYRecurrent stone formation in the urinary tract is a common and important problem that must be considered in daily urological practice. With a prevalence of> 10% and an expected recurrence rate of ≈ 50%, stone disease has an important effect on the healthcare system. It is generally agreed that patients with uric acid/urate, cystine or infection stones always should be treated pharmacologically. For calcium stone formers the treatment should be chosen according to the severity of the disease. Recurrence in patients with calcium‐stone disease can be prevented with general or specific dietary and drinking advice, and with pharmacological therapy. For idiopathic calcium stone formers the most convincing therapeutic effects have been reported with thiazide and alkaline citrate.

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Do Thiazides Prevent Recurrent Idiopathic Renal Calcium Stones?

Cited by 107 publications

References 4 publications

The Evidence-Based Use of Thiazide Diuretics in Hypertension and Nephrolithiasis

The Evidence-Based Use of Thiazide Diuretics in Hypertension and Nephrolithiasis

Metabolic Evaluation and Recurrence Prevention for Urinary Stone Patients: EAU Guidelines

Epidemiology and medical management of stone disease

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