Do the limits of serum prolactin in disconnection hyperprolactinaemia need re‐definition? A study of 226 patients with histologically verified non‐functioning pituitary macroadenoma

Karavitaki, Niki; Thanabalasingham, G; Shore, Helena C. A.; Trifănescu, Raluca; Ansorge, Olaf; Meston, N; Turner, Helen; Wass, John

doi:10.1111/j.1365-2265.2006.02627.x

Cited by 203 publications

(125 citation statements)

References 21 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…Hormonal response to SSA treatment was evaluated as percent change from baseline in random GH and IGF-1% after SSA treatment. Co-secretion of prolactin was considered to be present when prolactin values exceeded 100 ng/mL at diagnosis, in accordance with the current literature (Karavitaki et al 2006, Melmed et al 2011.…”

Section: Hormonal Assayssupporting

confidence: 64%

T2-weighted MRI signal predicts hormone and tumor responses to somatostatin analogs in acromegaly

Potorac

Pétrossians

Daly

et al. 2016

Endocrine-Related Cancer

View full text Add to dashboard Cite

GH-secreting pituitary adenomas can be hypo-, iso-or hyper-intense on T2-weighted MRI sequences. We conducted the current multicenter study in a large population of patients with acromegaly to analyze the relationship between T2-weighted signal intensity on diagnostic MRI and hormonal and tumoral responses to somatostatin analogs (SSA) as primary monotherapy. Acromegaly patients receiving primary SSA for at least 23:113 months were included in the study. Hormonal, clinical and general MRI assessments were performed and assessed centrally. We included 120 patients with acromegaly. At diagnosis, 84, 17 and 19 tumors were T2-hypo-, iso-and hyper-intense, respectively. SSA treatment duration, cumulative and mean monthly doses were similar in the three groups. Patients with T2-hypo-intense adenomas had median SSA-induced decreases in GH and IGF-1 of 88% and 59% respectively, which were significantly greater than the decreases observed in the T2-iso-and hyper-intense groups (P < 0.001). Tumor shrinkage on SSA was also significantly greater in the T2-hypo-intense group (38%) compared with the T2-iso-and hyper-intense groups (8% and 3%, respectively; P < 0.0001). The response to SSA correlated with the calculated T2 intensity: the lower the T2-weighted intensity, the greater the decrease in random GH (P < 0.0001, r = 0.22), IGF-1 (P < 0.0001, r = 0.14) and adenoma volume (P < 0.0001, r = 0.33). The T2-weighted signal intensity of GH-secreting adenomas at diagnosis correlates with hormone reduction and tumor shrinkage in response to primary SSA treatment in acromegaly. This study supports its use as a generally available predictive tool at diagnosis that could help to guide subsequent treatment choices in acromegaly.

show abstract

Section: Hormonal Assayssupporting

confidence: 64%

T2-weighted MRI signal predicts hormone and tumor responses to somatostatin analogs in acromegaly

Potorac

Pétrossians

Daly

et al. 2016

Endocrine-Related Cancer

View full text Add to dashboard Cite

show abstract

“…When only vital stains were used, 58.6% of SLN were detected in the first 50 cases; this rate increased to 72.4% in later cases (45). A surgeon could treat 53 cases with 90% success rate (33). Although only vital stains were used in the present study, 94.23% SLN were detected.…”

Section: Discussionmentioning

confidence: 96%

“…The false negative rate was 1 in 26 cases in the group treated with ISB, 2 in 23 cases in the colloid group, and 0% in the combined method group. This ratio was reported between 0.8% and 11% in various series (32,33,35,36,37,38). It was demonstrated that the false negative rate decreased with the increase in the experience of the surgeon.…”

Section: Discussionmentioning

confidence: 99%

“…Cserni found an average of 1.3 SLNs using only vital stains (32). Bass found a mean score of 2.02 in the cohort study of both methods and 1.92 SLNs in Cox regression analysis (33,34,35). Although the average number in the present study was higher than the number quoted in the literature, it is believed that the literature figures can be reached with an increase in the number of cases in working groups.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of the accuracy of isosulfan blue and technetium-99m lymphoscintigraphy to determine axillary lymph node metastasis in breast cancer

Albuz¹,

Akkurt²,

Ayan³

et al. 2017

Med J Islamic World Acad Sci

View full text Add to dashboard Cite

Breast cancer is the most common malignant neoplasm in women, accounting for nearly 31% of all female cancers (1-3). Most patients in developed countries are diagnosed with stages I and II, of which about 65% have no axillary lymph node (ALN) metastasis (4). However, complications such as edema, seroma, injuries of veins and nerves passing through ALN, limitation of arm movements, and pain are noted (5-7). The presence and number of axillary metastatic lymph nodes are the most important prognostic factors in breast cancer (4-7). The results of clinical evaluation of the axillary region are often misleading in approximately one third of patients (7-11). It was determined in 1930 that the lymphatic drainage of the primary tumor was directed to a focal point, from where it spread to other lymph nodes. This first station of lymph node metastasis was called sentinel lymph node (SLN) (12,13). Systematic studies of breast cancer have shown that cancer spreads to one or more SLNs before spreading to other ALNs (14,15). The present study aimed to evaluate axillary sentinal lymph node metastasis for breast cancer diagnosis. The effectiveness of technetium-99 m sulfur colloid, isosulfan blue (ISB), and concomitant use of technetium-99 m sulfur colloid and ISB was compared. SUMMARYThis study aimed to compare the efficiency of isosulfan blue (ISB) and colloid methods in determining metastatic conditions of axillary lymph node in sentinel lymph node biopsy (SLNB). This prospective study was performed between April 2005 and July 2009 at Gulhane Medical Faculty, Department of General Surgery. A total of 102 female patients diagnosed with breast cancer were enrolled in the clinic of Gulhane School of Medicine. According to the diagnostic protocols of SLN, the patients were divided into three groups as follows: ISB (group I), colloid (group II), and ISB and colloid (group III). SLN was identified in 49 of 52 patients (94.2%) in the ISB group; the sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), and false negativity (FN) ratio were found to be 90.9%, 75.8%, 96.1%, 55.5%, and 9.1%, respectively. On the contrary, the sentinel lymph node was identified in 38 of 38 (100%) patients in the colloid group; the sensitivity, specificity, PPV, NPV, and FN were found to be 88.2%, 100%, 100%, 91.3%, and 11.8%, respectively. In ISB and colloid groups; SLN was identified in 12 of 12 (100%) patients in the ISB and colloid groups; the sensitivity, specificity, PPV, NPV, and FN were found to be 100%, 100%, 100%, and 0%, respectively. This study showed that the combined methods applied to heterogeneous groups of patients for SLNB in breast cancer cases were minimally invasive and effective and hence could be used for evaluating nodal metastases.

show abstract

“…To determine sure nature of pituitary tumour, other pituitary hormonal assays were done -Serum ACTH -38 pg/ml (0-46), Serum cortisol -1.3 mcg/ml (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). It confirmed the nature of tumour as 'mixed pituitary adenoma' secreting FSH and prolactin.…”

Section: Case Reportmentioning

confidence: 92%

Follicle stimulating hormone secreting pituitary adenoma: a challenging diagnosis

Mehendale

Kalkal

Sarmalkar

et al. 2015

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Do the limits of serum prolactin in disconnection hyperprolactinaemia need re‐definition? A study of 226 patients with histologically verified non‐functioning pituitary macroadenoma

Cited by 203 publications

References 21 publications

T2-weighted MRI signal predicts hormone and tumor responses to somatostatin analogs in acromegaly

T2-weighted MRI signal predicts hormone and tumor responses to somatostatin analogs in acromegaly

Comparison of the accuracy of isosulfan blue and technetium-99m lymphoscintigraphy to determine axillary lymph node metastasis in breast cancer

Follicle stimulating hormone secreting pituitary adenoma: a challenging diagnosis

Contact Info

Product

Resources

About