Do the carotid body chemoreceptors mediate cardiovascular and sympathetic adjustments induced by sodium overload in rats?

Pedrino, Gustavo Rodrigues; Mourão, Aline A.; Moreira, M. C. S.; Silva, Elaine F. da; Lopes, Paulo Ricardo; Fajemiroye, James Oluwagbamigbe; Schoorlemmer, Guus H. M.; Sato, Mônica Akemi; Reis, Ângela Adamski da Silva; Rebelo, Ana Cristina Silva; Cravo, Sérgio L.

doi:10.1016/j.lfs.2016.03.045

Cited by 3 publications

(6 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the present results suggest for the first time that carotid bodies are important for the maintenance of the hypertensive response to acute NaCl load in non-anesthetized rats and are also part of the reflex pathway activated to regulate sodium balance during both acute and sub-chronic NaCl load. The present results together with previous studies showing that carotid bodies mediate sympathetic adjustments induced by hypernatremia in anesthetized rats (Silva et al, 2015; Pedrino et al, 2016), suggest that signals from carotid bodies modulate cardiovascular and fluid-electrolyte responses during salt overload.…”

Section: Discussionsupporting

confidence: 86%

“…Intravenous infusion of NaCl in the same concentration and dose (3 M NaCl, 1.8 mL/kg of body weight) has been used to produce a sudden increase in the plasma sodium concentration, without changing blood volume (Pedrino et al, 2006, 2016; Silva et al, 2013, 2015). Hypertonic NaCl infused intravenously in a concentration that produces hypernatremia triggers a sustained hypertensive response in intact rats (Pedrino et al, 2005; Silva et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Lesions of the SFO and AV3V reduced the pressor and natriuretic responses to acute NaCl load (Thornborough et al, 1973; McKinley et al, 1992; Pedrino et al, 2005). Moreover, it is also possible that additional information from portal-hepatic osmoreceptors and cardiovascular afferents participate in the natriuretic response to elevate Na + levels (Morris and Alexander, 1988; Ishiki et al, 1991; Morita et al, 1995; Pedrino et al, 2016). The signals from peripheral sensors might be integrated in the brain areas involved in the fluid-electrolyte control and cardiovascular regulation (Yamashita, 1977; Ciriello and Calaresu, 1980; Spyer, 1981) contributing for osmoregulation.…”

Section: Introductionmentioning

confidence: 99%

“…A study from our laboratory showed that carotid chemoreceptors integrity is important for the restoration of arterial blood pressure induced by intravenous infusion of hypertonic NaCl in rats submitted to hypotensive hemorrhage (Pedrino et al, 2011). Recently, we showed that carotid bodies inactivation prevented the renal vasodilation and sympathoinhibition to acute NaCl load in anesthetized rats (Pedrino et al, 2016). However, whether carotid bodies participate in the regulation of arterial pressure and effectively contribute for renal sodium excretion during acute and subchronic NaCl load in conscious rats have not been studied yet.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Role of the Carotid Bodies in the Hypertensive and Natriuretic Responses to NaCl Load in Conscious Rats

et al. 2018

View full text Add to dashboard Cite

Hyperosmotic challenges trigger a hypertensive response and natriuresis mediated by central and peripheral sensors. Here, we evaluated the importance of the carotid bodies for the hypertensive and natriuretic responses to acute and sub-chronic NaCl load in conscious rats. Male Wistar rats (250–330 g) submitted to bilateral carotid body removal (CBX) or sham surgery were used. One day after the surgery, the changes in arterial blood pressure (n = 6–7/group) and renal sodium excretion (n = 10/group) to intravenous infusion of 3 M NaCl (1.8 mL/kg b.w. during 1 min) were evaluated in non-anesthetized rats. Another cohort of sham (n = 8) and CBX rats (n = 6) had access to 0.3 M NaCl as the only source of fluid to drink for 7 days while ingestion and renal excretion were monitored daily. The sodium balance was calculated as the difference between sodium infused/ingested and excreted. CBX reduced the hypertensive (8 ± 2 mmHg, vs. sham rats: 19 ± 2 mmHg; p < 0.05) and natriuretic responses (1.33 ± 0.13 mmol/90 min, vs. sham: 1.81 ± 0.11 mmol/90 min; p < 0.05) to acute intravenous infusion of 3 M NaCl, leading to an increase of sodium balance (0.38 ± 0.11 mmol/90 min, vs. sham: -0.06 ± 0.10 mmol/90 min; p < 0.05). In CBX rats, sub-chronic NaCl load with 0.3 M NaCl to drink for 7 days increased sodium balance (18.13 ± 4.45 mmol, vs. sham: 5.58 ± 1.71 mmol; p < 0.05) and plasma sodium concentration (164 ± 5 mmol/L, vs. sham: 140 ± 7 mmol/L; p < 0.05), without changing arterial pressure (121 ± 9 mmHg, vs. sham: 116 ± 2 mmHg). These results suggest that carotid bodies are important for the maintenance of the hypertensive response to acute hypertonic challenges and for sodium excretion to both acute and chronic NaCl load.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Role of the Carotid Bodies in the Hypertensive and Natriuretic Responses to NaCl Load in Conscious Rats

et al. 2018

View full text Add to dashboard Cite

show abstract

“…A tracheostomy was performed to reduce airway resistance. The CB chemosensory discharge was measured as previously described (Del Rio et al 2011;Moya et al 2016;Pedrino et al 2016;Peng et al 2012). Briefly, the sternocleidomastoid muscles were displaced laterally, exposing the carotid sheath of the cervical fascia.…”

Section: Surgical Proceduresmentioning

confidence: 99%

Endothelin-1-Mediated Mechanisms in the Carotid Body Modulates Cardiovascular Responses in Rats Exposed to Chronic Intermittent Hypoxia

Yang

et al. 2018

Int J Pept Res Ther

View full text Add to dashboard Cite

Chronic intermittent hypoxia (CIH), the main feature of obstructive sleep apnea (OSA), is associated with hypertension. The increased of carotid body (CB) sensitivity due to enhanced sympathetic efferent may be mainly responsible for the elevation of blood pressure. Accordingly, we studied this effect of Endothelin-1 (ET-1)-induced CB chemosensory response to CIH, as a vasoactive peptide expressed in CB. The purpose of this study was to investigate the mean arterial blood pressure (MAP) and renal sympathetic nerve activity (RSNA) responses in CIH group by injecting ET-1 to directly stimulate CB chemoreceptor. Furthermore, whether ET receptor-mediated PKC and p 38 MAPK signaling pathway was involved in CIHinduced CB activation was also studied. Male Sprague-Dawley rats were exposed to CIH (8 h/day for 3 weeks) and the MAP and RSNA were recorded in CIH rats and Sham rats. Our results demonstrated that ET-1-induced MAP and RSNA increase were mainly mediated by ET A receptor activation in CB chemosensory after CIH exposure. Moreover, P 38 MAPK and PKC signaling pathway might be involved in ET-1-induced increase of MAP and RSNA in CIH group, which provided a potential therapeutic target of OSA.

show abstract

Novel choline analog 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol produces sympathoinhibition, hypotension, and antihypertensive effects

Menegatti

Carvalho

Lião

et al. 2019

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

Do the carotid body chemoreceptors mediate cardiovascular and sympathetic adjustments induced by sodium overload in rats?

Cited by 3 publications

References 43 publications

Role of the Carotid Bodies in the Hypertensive and Natriuretic Responses to NaCl Load in Conscious Rats

Role of the Carotid Bodies in the Hypertensive and Natriuretic Responses to NaCl Load in Conscious Rats

Endothelin-1-Mediated Mechanisms in the Carotid Body Modulates Cardiovascular Responses in Rats Exposed to Chronic Intermittent Hypoxia

Novel choline analog 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol produces sympathoinhibition, hypotension, and antihypertensive effects

Contact Info

Product

Resources

About