Do Specialized Bariatric Multivitamins Lower Deficiencies After Sleeve Gastrectomy?

Smelt, Hendrika J.M.; Loon, Saskia van; Pouwels, Sjaak; Boer, Arjen‐Kars; Smulders, J. F.; Aarts, Edo O.

doi:10.1007/s11695-019-04191-x

Cited by 16 publications

(17 citation statements)

References 38 publications

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“…Whereas no vitamin B6 deficiencies were observed, hypervitaminosis for vitamin B6 was highly prevalent in both groups (39%). This is in line with previous research reporting a low prevalence of vitamin B6 deficiency (0–0.5%) but excess vitamin B6 levels in up to 50% of the patients [ 7 , 8 , 14 , 23 ]. Excessive serum levels of vitamin B6 can cause neuropathic symptoms [ 24 ], but the toxicity of vitamin B6 may depend on which form of vitamin B6 is used in a supplement.…”

Section: Discussionsupporting

confidence: 93%

Optimizing Multivitamin Supplementation for Sleeve Gastrectomy Patients

et al. 2021

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Purpose Micronutrient deficiencies are frequently reported after sleeve gastrectomy (SG), and therefore lifelong daily multivitamin supplementation is highly recommended. Based on literature and the results of a previous randomized controlled trial, a specialized multivitamin supplement for SG patients was further optimized (WLS Optimum 2.0, FitForMe). The present study reports on its short-term effectiveness. Materials and Methods An open-label study was performed in which 76 patients were included to receive WLS Optimum 2.0 for 12 months (Opt 2.0 group). This group was compared with a group of 75 patients that had received WLS Optimum 1.0 for 12 months during a previous study (Opt 1.0 group). Results Intention-to-treat analysis (Opt 1.0, n = 69; Opt 2.0, n = 75) showed higher serum levels of vitamin B12, vitamin B6, and zinc, and a lower prevalence of deficiencies for vitamin B12 and phosphate in the Opt 2.0 group. MCV and serum folic acid levels were higher in the Opt 1.0 group. Over the 12-month study period, mean increase in serum levels of phosphate, vitamin B6, and zinc was higher in the Opt 2.0 group, and MCV and serum vitamin D levels increased more in the Opt 1.0 group. Conclusion The present study showed that the use of a specialized multivitamin supplement for SG patients is effective at preventing deficiencies for most vitamins and minerals, specifically in compliant patients. However, a strict follow-up regime remains necessary to monitor nutritional status and to improve patient compliance.

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Section: Discussionsupporting

confidence: 93%

Optimizing Multivitamin Supplementation for Sleeve Gastrectomy Patients

et al. 2021

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“…Full‐text review of 355 studies resulted in the exclusion of 273 studies (Figure 1). Among the 82 included studies, 15 were of vitamin B 1 , 18–32 28 of folate, 18–45 42 of vitamin B 12 , 18–59 13 of vitamin A, 18,19,23,25,26,28–30,36,39,55,60,61 11 of vitamin E, 18,19,23,25,26,28,29,61–64 57 of vitamin D, 18,19,21–33,37–39,41,42,45,47,51,52,55,59,61,65–94 42 of calcium,…”

Section: Resultsmentioning

confidence: 99%

“…Twenty studies 19,24–27,31–34,37,40,42,43,46,48,57,95,101,103,104 presenting post‐bariatric changes in ferritin levels with iron supplementation per guidelines reported that the ferritin levels significantly decreased by 16.42 μg/ml (95% CI, −18.29 to −14.56) at 6–11 months (Table 3). The ferritin levels also decreased at ≥24 months after SG despite supplementation per guidelines (WMD, −54.93 μg/ml; 95% CI, −77.19 to −32.67).…”

Section: Resultsmentioning

confidence: 99%

Micronutrient status in bariatric surgery patients receiving postoperative supplementation per guidelines: Insights from a systematic review and meta‐analysis of longitudinal studies

Kwon

et al. 2021

Obesity Reviews

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Summary The micronutrient status and optimal monitoring schedule after bariatric surgery have not been sufficiently assessed. This systematic review and meta‐analysis investigated the longitudinal changes in micronutrient status after bariatric surgery. PubMed, EMBASE, and Cochrane Library were searched for articles that measured preoperative and postoperative serum micronutrient levels in patients undergoing Roux‐en‐Y gastric bypass (RYGB) or sleeve gastrectomy (SG). Among guideline‐adherent studies, the longitudinal changes in micronutrient status were investigated using weighted mean difference (WMD) using a random‐effects model. Among the 82 included studies, the guideline adherence rates for micronutrient supplementation after bariatric surgery did not exceed 20%. In patients supplemented per guidelines, vitamin A significantly decreased after RYGB by −7.54 (95% confidence interval [CI], −10.16 to −4.92) μg/dl at 12–23 months, vitamin E decreased after RYGB by −2.35 (95% CI, −3.65 to −1.05) μg/dl at ≥24 months, and ferritin by −54.93 (95% CI, −77.19 to −32.67] μg/L at ≥24 months after SG, compared with baseline, with moderate level of evidence. Significant decreases in micronutrient levels at certain follow‐up intervals in studies with supplementation per guidelines need to be considered to establish a post‐bariatric micronutrient monitoring schedule for timely detection and management of micronutrient deficiencies.

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“…Zarshenas et al reported about an inconsistent adherence of MVS intake after bariatric surgery (5) . Many other studies have shown that long-term adherence of bariatric patients to MVS intake is poor (10,(12)(13)(14)(15)(16)(17)(18) . However, it is unclear which factors contribute to patient Abbreviations: LRYGB: laparoscopic Roux-en-Y gastric bypass; LSG: Laparoscopic sleeve gastrectomy; MVS: multivitamin supplementation; OAGB/MGB: One Anastomosis/Mini-Gastric Bypass adherence in taking MVS.…”

Section: Introductionmentioning

confidence: 99%

Patient adherence to multivitamin supplementation after bariatric surgery: a narrative review

et al. 2020

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Morbid obesity is a growing problem worldwide and has subsequently resulted in a wide application of bariatric surgery to achieve long-term weight loss and improvement of obesity-related co-morbidities. In spite of these clinical benefits, vitamin deficiencies are common after bariatric surgery; therefore, lifelong multivitamin supplementation (MVS) is recommended. However, patient adherence to MVS intake is generally poor. The aim of this narrative review is to analyse which factors influence the adherence of MVS intake after bariatric surgery. To provide an extensive overview, we will discuss the different factors that influence MVS use in patients who underwent bariatric surgery, but also review the literature on MVS in other patient groups.

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Do Specialized Bariatric Multivitamins Lower Deficiencies After Sleeve Gastrectomy?

Cited by 16 publications

References 38 publications

Optimizing Multivitamin Supplementation for Sleeve Gastrectomy Patients

Optimizing Multivitamin Supplementation for Sleeve Gastrectomy Patients

Micronutrient status in bariatric surgery patients receiving postoperative supplementation per guidelines: Insights from a systematic review and meta‐analysis of longitudinal studies

Patient adherence to multivitamin supplementation after bariatric surgery: a narrative review

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