Do Sleep Disturbances have a Dual Effect on Alzheimer’s Disease?

Arjmandi-Rad, Shirin; Ebrahimnejad, Mahshid; Issazadeh, Yasaman; Vaseghi, Salar

doi:10.1007/s10571-022-01228-1

Cited by 3 publications

(4 citation statements)

References 184 publications

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“…49,55 This imbalance not only compromises the immune system's ability to combat infections but also contributes to the development of chronic inflammatory conditions, ranging from metabolic disorders to neurodegenerative diseases. 56,57 Our study illuminated activations of fundamental cellular pathways, including oxidative stress and integrated stress response pathways, in GABAergic neurons due to sleep deprivation. GABAergic neurons play pivotal roles in regulating sleep, storing memory, and safeguarding the body against stressors.…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

“…Considering that sleep deprivation leads to a pro‐inflammatory shift, with elevated levels of pro‐inflammatory cytokines and a blunted anti‐inflammatory response 49,55 . This imbalance not only compromises the immune system's ability to combat infections but also contributes to the development of chronic inflammatory conditions, ranging from metabolic disorders to neurodegenerative diseases 56,57 …”

Section: Discussionmentioning

confidence: 99%

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Exploring the potential relationship between short sleep risks and cognitive function from the perspective of inflammatory biomarkers and cellular pathways: Insights from population‐based and mice studies

You,

Li,

Zhang

et al. 2024

CNS Neurosci Ther

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AimsThe molecular mechanism of short‐sleep conditions on cognition remains largely unknown. This research aimed to investigate associations between short sleep, inflammatory biomarkers and cognitive function in the US population (NHANES data 2011–2014) and explore cellular mechanisms in mice.MethodsSystemic immune‐inflammation index (SII) was calculated using blood‐cell based biomarkers. Further, we employed integrated bioinformatics and single‐cell transcriptomics (GSE137665) to examine how short sleep exposure influenced the molecular pathways associated with inflammation in the brain. To explore the signaling pathways and biological processes of sleep deprivation, we carried out enrichment analyses utilizing the GO and KEGG databases.ResultsPopulation results showed that, compared with normal sleep group, severe short sleep was associated with lower cognitive ability in all the four tests. Moreover, a higher SII level was correlated with lower scores of cognitive tests. In mice study, elevated activation of the inflammatory pathway was observed in cell subgroups of neurons within the sleep deprivation and recovery sleep cohorts. Additionally, heightened expression of oxidative stress and integrated stress response pathways was noted in GABAergic neurons during sleep deprivation.ConclusionThis study contributed to the understanding of the influence of short sleep on cognitive function and its cellular mechanisms.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Exploring the potential relationship between short sleep risks and cognitive function from the perspective of inflammatory biomarkers and cellular pathways: Insights from population‐based and mice studies

You,

Li,

Zhang

et al. 2024

CNS Neurosci Ther

View full text Add to dashboard Cite

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“…Neural mechanisms involved in sleep disturbances in PD [ 79 , 80 ], and even in sleep disturbance itself [ 81 , 82 ], are so complicated. Neurodegeneration in PD (and also other neurodegenerative disorders) directly affects sleep/wakefulness mechanisms and leads to sleep disturbance [ 83 ].…”

Section: Pd and Sleepmentioning

confidence: 99%

Parkinson’s Disease: A Narrative Review on Potential Molecular Mechanisms of Sleep Disturbances, REM Behavior Disorder, and Melatonin

Samizadeh,

Fallah,

Toomarisahzabi

et al. 2023

Brain Sciences

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Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. There is a wide range of sleep disturbances in patients with PD, such as insomnia and rapid eye movement (REM) sleep behavior disorder (or REM behavior disorder (RBD)). RBD is a sleep disorder in which a patient acts out his/her dreams and includes abnormal behaviors during the REM phase of sleep. On the other hand, melatonin is the principal hormone that is secreted by the pineal gland and significantly modulates the circadian clock and mood state. Furthermore, melatonin has a wide range of regulatory effects and is a safe treatment for sleep disturbances such as RBD in PD. However, the molecular mechanisms of melatonin involved in the treatment or control of RBD are unknown. In this study, we reviewed the pathophysiology of PD and sleep disturbances, including RBD. We also discussed the potential molecular mechanisms of melatonin involved in its therapeutic effect. It was concluded that disruption of crucial neurotransmitter systems that mediate sleep, including norepinephrine, serotonin, dopamine, and GABA, and important neurotransmitter systems that mediate the REM phase, including acetylcholine, serotonin, and norepinephrine, are significantly involved in the induction of sleep disturbances, including RBD in PD. It was also concluded that accumulation of α-synuclein in sleep-related brain regions can disrupt sleep processes and the circadian rhythm. We suggested that new treatment strategies for sleep disturbances in PD may focus on the modulation of α-synuclein aggregation or expression.

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The Interaction Effect of Sleep Deprivation and Treadmill Exercise in Various Durations on Spatial Memory with Respect to the Oxidative Status of Rats

et al. 2023

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Do Sleep Disturbances have a Dual Effect on Alzheimer’s Disease?

Cited by 3 publications

References 184 publications

Exploring the potential relationship between short sleep risks and cognitive function from the perspective of inflammatory biomarkers and cellular pathways: Insights from population‐based and mice studies

Exploring the potential relationship between short sleep risks and cognitive function from the perspective of inflammatory biomarkers and cellular pathways: Insights from population‐based and mice studies

Parkinson’s Disease: A Narrative Review on Potential Molecular Mechanisms of Sleep Disturbances, REM Behavior Disorder, and Melatonin

The Interaction Effect of Sleep Deprivation and Treadmill Exercise in Various Durations on Spatial Memory with Respect to the Oxidative Status of Rats

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