Do Side-by-Side Anastomoses Decrease the Risk of Recurrence in Crohn's Disease?

Molloy, Jeffrey W.; Kim, Edward; Mahadevan, Uma

doi:10.1053/j.gastro.2010.03.017

Cited by 4 publications

(1 citation statement)

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“…With this in mind, prevention strategies need to be developed and implemented within the community, based on existing knowledge about risk factors and natural CRC disease progression. There is extensive research examining the risk factors for CRC; including high red meat consumption, high fat low fiber diet, alcohol and tobacco consumption, obesity, lack of physical activity, and sleep deprivation (Huxley et al, 2009; Wei et al, 2009; Basterfield and Mathers, 2010; Chan and Giovannucci, 2010; Thompson et al, 2011). These lifestyle factors are the major cause of disease burden globally, and combined with physician’s tendency to prescribe medication rather than prescribing a healthy lifestyle, have resulted in a global health crisis (Yousefi et al, 2012; Franceschi and Wild, 2013).…”

Section: Introductionmentioning

confidence: 99%

Identifying Molecular Targets of Lifestyle Modifications in Colon Cancer Prevention

Derry¹,

Raina²,

Agarwal³

et al. 2013

Front. Oncol.

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One in four deaths in the United States is cancer-related, and colorectal cancer (CRC) is the second leading cause of cancer-associated deaths. Screening strategies are utilized but have not reduced disease incidence or mortality. In this regard, there is an interest in cancer preventive strategies focusing on lifestyle intervention, where specific etiologic factors involved in cancer initiation, promotion, and progression could be targeted. For example, exposure to dietary carcinogens, such as nitrosamines and polycyclic aromatic hydrocarbons influences colon carcinogenesis. Furthermore, dietary deficiencies could alter sensitivity to genetic damage and influence carcinogen metabolism contributing to CRC. High alcohol consumption increases the risk of mutations including the fact that acetaldehyde, an ethanol metabolite, is classified as a group 1 carcinogen. Tobacco smoke exposure is also a risk factor for cancer development; approximately 20% of CRCs are associated with smoking. Additionally, obese patients have a higher risk of cancer development, which is further supported by the fact that physical activity decreases CRC risk by 55%. Similarly, chronic inflammatory conditions also increase the risk of CRC development. Moreover, the circadian clock alters digestion and regulates other biochemical, physiological, and behavioral processes that could influence CRC. Taken together, colon carcinogenesis involves a number of etiological factors, and therefore, to create effective preventive strategies, molecular targets need to be identified and beleaguered prior to disease progression. With this in mind, the following is a comprehensive review identifying downstream target proteins of the above lifestyle risk factors, which are modulated during colon carcinogenesis and could be targeted for CRC prevention by novel agents including phytochemicals.

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