Do S100β protein level increases due to inflammation during                 cardiopulmonary bypass occur without any neurological deficit?

Özatık, Mehmet Ali; Tarcan, Onurcan; Kale, Arzum; Aşkın, Göktan; Balcı, Mustafa; Ündar, Akif; Küçükaksu, Deniz Süha; Şener, Erol; Taşdemi̇r, Oğuz

doi:10.1191/0267659102pf597oa

Cited by 12 publications

(12 citation statements)

References 23 publications

(27 reference statements)

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“…Therefore, a high expression level of S-100β in the blood indicates not only brain injury, but also increased permeability of the blood-brain barrier. The S-100β protein level in plasma is not influenced by hemolysis, hypothermia, heparin, and other narcotic drugs (Ozatik et al, 2002). Plasma concentrations of the S-100β protein exceeding 0.5 μg/L is the diagnosis criterion for brain injury (Jönsson et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Protective effects of remifentanil preconditioning on cerebral injury during pump-assisted coronary artery bypass graft

Zhang¹,

Zhou²,

Jin³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. The protective effects of remifentanil preconditioning on serum superoxide dismutase (SOD) and malondialdehyde (MDA) during pump-assisted coronary artery bypass graft (CABG) were investigated. Forty pump-assisted CABG patients were randomly divided into a remifentanil preconditioning group (R group) and a control group (C group, N = 10; normal saline). The R group was further divided into 3 sub-groups (R1, R2, and R3; N = 10 per group) according to the remifentanil dose (0.6, 1.2, and 1.8 μg·kg -1 ·min -1 , respectively). A venous blood sample was taken at anesthesia induction (T 0 ), before cardiopulmonary bypass (CPB) (T 1 ), CPB 30 min (T 2 ), and after CPB (T 3 ), and protein concentrations were measured. Patients were tested 24 h before and after the operation with the Mini-Mental State Examination (MMSE), and the difference was calculated. The MMSE score difference in the R3 group was lower than those of the other 3 groups (P < 0.05). At T 2 and T 3 , the R3 group showed a significant decrease in S-100β protein and MDA and an increase in SOD (P < 0.05) compared with the other groups, and S-100β was negatively correlated with SOD activity (T 2 : r = -0.76, -0.80, P < 0.01; T 3 : r = -0.795, P < 7659 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (3): 7658-7665 (2014) Remifentanil preconditioning on cerebral injury 0.01), and was positively correlated with MDA density (T 2 : r = 0.71, P < 0.01; T 3 : r = 0.71, P < 0.01). In conclusion, high-dosage remifentanil preconditioning played a protective role on brain damage, possibly through inhibition of the oxidative stress response.

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Section: Discussionmentioning

confidence: 99%

Protective effects of remifentanil preconditioning on cerebral injury during pump-assisted coronary artery bypass graft

Zhang¹,

Zhou²,

Jin³

et al. 2014

Genet. Mol. Res.

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“…Ozatik et al [20 ]concluded that there is no correlation between serum S100B concentration and neurological deficits, but a high serum level of the protein is associated with increased levels of serum inflammatory mediators and systemic inflammatory response. In order to frame the role of S100B in the inflammatory reaction, we should consider that it has been demonstrated that some molecules, like vasopressin, physiologically released by the brain, increase after a trauma.…”

Section: Discussionmentioning

confidence: 99%

S100B Is Not a Reliable Prognostic Index in Paediatric TBI

et al. 2007

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Background: As far as paediatric traumatic brain injury is concerned, it is difficult to quantify the extent of the primary insult, to monitor secondary changes and to predict neurological outcomes by means of the currently used diagnostic tools: physical examination, Glasgow Coma Scale (GCS) score and computed tomography. For this reason, several papers focused on the use of biochemical markers (S100B, neuron-specific enolase) to detect and define the severity of brain damage and predict outcome after traumatic head injury or cardiac arrest. Objective: The aim of this paper is measuring the range of S100B serum concentrations in children affected by traumatic brain injury and describing the possible roles of this protein in the reaction to trauma. Methods: Fifteen children aged 1–15 years were included in the study. Traumatic brain injury severity was defined by paediatric GCS score as mild (9 patients), moderate (2 patients) or severe (4 patients). Blood samples for S100B serum measurement were taken at emergency department admission and after 48 h. Results: The serum S100B concentration was higher in the group of severe trauma patients, who scored the lowest on the GCS at admission, and among them, the highest values were reported by the children with concomitant peripheral lesions. Conclusions: The role of S100B in paediatric traumatic brain injury has not been clarified yet, and the interpretation of its increase when the head trauma is associated with other injuries needs the understanding of the physiopathological mechanisms that rule its release in the systemic circulation. The levels of S100B in serum after a brain injury could be related to the mechanical discharge from a destroyed blood-brain barrier, or they could be due to the active expression by the brain, as a part of its involvement in the systemic inflammatory reaction. Early increase of this protein is not a reliable prognostic index of neurological outcome after pediatric traumatic brain injury, since even very elevated values are compatible with a complete neurological recovery.

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“…[24] Özatik ve ark. [55] S100b'daki artış-ların serum enflamatuvar mediatörler ve sistemik enflamatuvar yanıt artışıyla ilişkili olduğunu belirtmişlerdir.…”

Section: Nöron Spesifik Enolazunclassified

Neurocognitive dysfunction after cardiac surgery and biochemical markers

Öztürk¹

2013

Turk Gogus Kalp Dama

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Do S100β protein level increases due to inflammation during cardiopulmonary bypass occur without any neurological deficit?

Abstract: During CPB, serum S100beta protein level increases and this increase is higher in the nonpulsatile group. High serum level of S100beta protein is associated with increased levels of serum inflammatory mediators and systemic inflammatory response.

Cited by 12 publications

References 23 publications

Protective effects of remifentanil preconditioning on cerebral injury during pump-assisted coronary artery bypass graft

Protective effects of remifentanil preconditioning on cerebral injury during pump-assisted coronary artery bypass graft

S100B Is Not a Reliable Prognostic Index in Paediatric TBI

Neurocognitive dysfunction after cardiac surgery and biochemical markers

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