Do Prostatic Infarction, Prostatic Inflammation and Prostate Morphology Play a Role in Acute Urinary Retention?

Tuncel, Altuğ; Uzun, Burcin; Eruyar, Tuğrul; Karabulut, Erdem; Seçkin, Selda; Atan, Ali

doi:10.1016/j.eururo.2005.05.001

Cited by 51 publications

(58 citation statements)

References 25 publications

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“…12 Tuncel et al found a high serum PSA level (over 2 ng/ ml) and large prostate volume (over 40 ml) to be the strongest predictors for AUR. 6 In the present study, the mean PSA at presentation was very high (397 ng/ml), but this was largely a result of the high proportion of men with ACP. Mean serum PSA was significantly higher in the group with ACP (899.5 ng/ml) than in the group with BPH (18.6 ng/ml).…”

Section: Discussionmentioning

confidence: 89%

“…5 Prostatic inflammation is associated with a threefold higher relative risk for AUR. 6 Urinary stasis due to large postvoid residual volumes may induce urinary tract infection (UTI), which leads to prostatic inflammation. There is conflicting evidence with regard to prostatic infarction.…”

Section: Introductionmentioning

confidence: 99%

“…8 Tuncel et al also found no association between prostatic infarction and AUR. 6 The objectives of this study were to investigate the aetiology, clinical features, complications and management of men hospitalised with urinary retention in a developing African country, and to analyse differences between men with AUR versus chronic urinary retention (CUR). S Afr Fam Pract 2011 of South Africa.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of men with acute versus chronic urinary retention: aetiology, clinical features and complications

Vuuren

Heyns

Zarrabi

2011

South African Family Practice

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of men with acute versus chronic urinary retention: aetiology, clinical features and complications

Vuuren

Heyns

Zarrabi

2011

South African Family Practice

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“…Kefi et al [14] reported that there was no difference between the patients with and without AUR with respect to prostatic volume and the weight of resected prostatic tissue; however, there was a significant difference with respect to the tPSA level. Tuncel et al [15] and Atan et al [16] also found that the serum tPSA level was an important risk factor in AUR etiology, whereas the prostatic size was not. Our findings were opposite to theirs, both in terms of tPSA and Rt.…”

Section: Discussionmentioning

confidence: 99%

“…Tuncel et al [15] found that the risk of AUR was approximately 3 times higher in patients with prostatic inflammation, and they speculated that this elevated risk was dependent on the induction of urinary tract infections by post-void residual urine. However, it should be noted that not all chronic prostatitis patients develop AUR, and patients with a documented urinary tract infection were not included in our study.…”

Section: Discussionmentioning

confidence: 99%

The risk factors for acute urinary retention in patients with benign prostatic hyperplasia

Demirel¹,

Gökkaya²,

Özden³

et al. 2012

Turkish Journal of Urology

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ÖZETAmaç: Akut üriner retansiyonun (AUR) ensık sebebi benign prostat hiperplazisidir(BPH). AUR'un etyolojisini ayrıntılı bir şekilde araştırmak için, BPH'lı hastalarda AUR ve histolojik prostatik inflamasyon ilişkisini değerlendirdik. Gereç ve Yöntem:Çalışmaya Ocak-Aralık 2008 tarihleri arasında BPH'ne bağlı AUR veya alt üriner sistem semptomları (AÜSS) nedeniyle trans üretral rezeksiyon-prostat (TURP) yapılan 226 hasta dahil edildi. Hastalar AUR(+) (n=89) ve AUR(-) (n=137) olmak üzere 2 gruba ayrıldı. Bu iki grup; yaşlarına, rezeke edilen prostat dokusu ağırlığına (Rt), total prostat spesifik antijen (tPSA) düzeylerine ve prostat dokusu patolojisinde inflamasyon varlığına göre karşılaştırıldı. AUR için bağımsız risk faktörleri lojistik regresyon analizi ile değerlendirildi ve P değeri <0.005 ise anlamlı olarak kabul edildi. Bulgular: Bu 226 hastanın ortalama yaşları 67.7±7.7 yıl, ortalama tPSA değeri 6.45±4.97 ng/ml, ortalama rezeke edilen prostat ağırlığı (Rt) 25.47±21.77 gr. idi. Ortalama yaş ve ortalama Rt, AUR(+) grubunda diğer gruba göre anlamlı olarak daha fazla idi (p<0.0001 ve p= 0.031). Prostatik inflamasyonu olan hastalarda AUR gelişme riski olmayanlara göre anlamlı olarak daha yüksek bulundu (p= 0.049). Yapılan lojistik regresyon analizinde, 70 yaşın üzerinde, 25 gr'dan fazla doku çıkarılması ve prostatik inflamasyon varlığı AUR gelişiminde bağımsız risk faktörleri olarak bulundu.Sonuç: Sonuçlarımız göstermektedir ki; BPH'li hastalarda 70 yaşın üzerinde olmak, 25 gr'dan fazla doku çıkarılması ve prostatik inflamasyon varlığı AUR gelişiminde bağımsız risk faktörleridir.Anahtar sözcükler: Akut üriner retansiyon; benign prostat hiperplazisi; alt üriner sistem semptomları; prostat spesifik antijen. ABSTRACT Objective:The most common cause of obstructive acute urinary retention (AUR) is benign prostatic hyperplasia (BPH). To investigate the etiology of AUR, we evaluated the relationship between AUR and histological prostatic inflammation in patients with BPH. Materials and Methods:Between January and December of 2008, 226 patients who underwent transurethral resection of prostate (TURP) for AUR or lower urinary tract symptoms (LUTS) as a result of BPH were included in the study. Patients were classified into AUR(+) (n=89) and AUR(-) (n=137) groups. The two groups were compared along the following dimensions: age, weight of resected prostatic tissue (Rt), total prostate specific antigen (tPSA) levels and the presence of inflammation in the prostatic pathology. Independent risk factors for AUR were evaluated using logistic regression analysis. P values <0.05 were considered significant. Results:The mean age of the 226 patients was 67.7±7.7 years; the mean tPSA level was 6.45±4.97 ng/ml; and the mean weight of resected prostatic tissue (Rt) was 25.47±21.77 g. The mean age and Rt of the AUR(+) group were significantly higher than those of the AUR(-) group (p<0.0001 and p= 0.031, respectively). The odds of AUR were significantly higher in the patients with inflammation than in those without (p= 0.049). An age ...

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Serenoa repens, lycopene and selenium versus tamsulosin for the treatment of LUTS/BPH. An Italian multicenter double‐blinded randomized study between single or combination therapy (PROCOMB trial)

et al. 2014

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BACKGROUND. Phytotherapy has been used to treat patients with lower urinary tract symptoms (LUTS). We evaluated the efficacy and tolerability of combination therapy between Serenoa Repens (SeR), Lycopene (Ly), and Selenium (Se) þ tamsulosin versus single therapies. METHODS. PROCOMB trial (ISRCTN78639965) was a randomized double-blinded, doubledummy multicenter study of 225 patients between 55 and 80 years old, PSA 4 ng/ml, IPSS !12, prostate volume 60 cc, Qmax 15 ml/sec, postvoid residual urine (PVR) <150 ml. Participants were randomized group A (SeR-Se-Ly), group B (tamsulosin 0.4 mg), group C (SeR-Se-Ly þ tamsulosin 0.4 mg). The primary endpoints of the study were the reduction of IPSS, PVR, and increase of Qmax in group C versus monotherapy groups. RESULTS. The decrease for combination therapy was significantly greater versus group A (P < 0.05) and group B (P < 0.01) for IPSS and versus group A (P < 0.01) for PVR from baseline This study has been designed and conducted independently. Konpharma provided support for this study. Data collection and management and all statistical analyses were performed and retained by data manager (R.A.). The corresponding author and other co-authors interpreted the data and participated in the preparation, review and approval of the manuscript. to 6 months. A greater decrease in IPSS was observed for Group C versus group A (P < 0.01) and increase in Qmax versus group B (P < 0.01), from 6 months to 12 months. At one year, the changes of IPSS and Qmax were greater for Group C versus monotherapies (each comparison <0.05). The proportions of men with a decrease of at least three points (each comparison P < 0.05) and decrease of 25% for IPSS (each comparison P < 0.01) were greater for Group C. CONCLUSION. SeR-Se-Ly þ tamsulosin therapy is more effective than single therapies in improving IPSS and increasing Qmax in patients with LUTS.

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Do Prostatic Infarction, Prostatic Inflammation and Prostate Morphology Play a Role in Acute Urinary Retention?

Cited by 51 publications

References 25 publications

Comparison of men with acute versus chronic urinary retention: aetiology, clinical features and complications

Comparison of men with acute versus chronic urinary retention: aetiology, clinical features and complications

The risk factors for acute urinary retention in patients with benign prostatic hyperplasia

Serenoa repens, lycopene and selenium versus tamsulosin for the treatment of LUTS/BPH. An Italian multicenter double‐blinded randomized study between single or combination therapy (PROCOMB trial)

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