Do Pretransplant C-Peptide Levels Influence Outcomes in Simultaneous Kidney-Pancreas Transplantation?

Combined Pancreas-Kidney Transplantation for Patients With End-Stage Nephropathy Caused by Type-2 Diabetes Mellitus

“…The small sample size in T2DM patients and the effects of confounding variables, especially recipient age, were the reasons for not achieving statistical significance. Similar results have also been reported by Singh et al (14) in a small series of patients. Unfortunately, in our cohort, the survival rate was impacted by late fatal fungal infection in two recipients.…”

Outcomes of Simultaneous Pancreas-Kidney Transplantation in Type 2 Diabetic Recipients

“…Another smaller study defined T2DM by a C-peptide level Ն2.0 ng/ml (n ϭ 7) and compared SPK outcomes with T1DM recipients. In T1DM and T2DM, recipients' 3-year patient survival was 94% and 71%, death-censored pancreas survival was 87% and 100%, and deathcensored kidney survival was 95% and 100%, respectively (15). Two additional studies reported outcomes in T2DM patients with pancreas transplants.…”

Outcomes After Simultaneous Pancreas and Kidney Transplantation and the Discriminative Ability of the C-peptide Measurement Pretransplant Among Type 1 and Type 2 Diabetes Mellitus

“…Since there are no absolute established diagnostic criteria to assign a type of diabetes, individual centers have used their discretion in adopting criteria in the labeling of a patient as T2DM. Prior reports have included a combination of C-peptide cutoffs – C-peptide >0.8 ng/mL, 2 C-peptide >2 ng/mL5 and clinical criteria based on American Diabetes Association and World Health Organization guidelines. However, since the kidney is the major site for C-peptide catabolism and excretion,6-10 the utilization of C-peptide alone to phenotype diabetes in patients with ESRD is imprecise.…”