Do Postoperative Platelet-Rich Plasma Injections Accelerate Early Tendon Healing and Functional Recovery After Arthroscopic Supraspinatus Repair?

Wang, Allan; McCann, Philip; Colliver, Jess; Koh, Eamon; Ackland, Tim; Joss, Brendan; Zheng, Minghao; Breidahl, Bill

doi:10.1177/0363546515572602

Cited by 107 publications

(55 citation statements)

References 46 publications

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“…Wang et al were the first to evaluate whether repeated postoperative application of PRP improves early tendon healing after arthroscopic double-row repair of the supraspinatus tendon [9]. Half of the patient cohort received two PRP applications-at 7 and 14 days postoperatively.…”

Section: Discussionmentioning

confidence: 99%

“…ACP is said to contain approximately 2.1 times higher platelet concentrations and 5 to 25 times higher growth factor levels as compared with whole blood [9]. Contrary to other PRP systems, ACP has a significantly reduced quantity of white blood cells, which may be detrimental to tendon repair because of their proinflammatory compounds, such as matrix metalloproteinases and reactive oxygen species [5,10,11].…”

Section: Application Of Platelet-rich Plasmamentioning

confidence: 99%

See 1 more Smart Citation

Two-staged application of PRP in arthroscopic rotator cuff repair: a matched-pair analysis

Gwinner

Gerhardt

Haneveld

et al. 2016

Arch Orthop Trauma Surg

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Section: Discussionmentioning

confidence: 99%

Section: Application Of Platelet-rich Plasmamentioning

confidence: 99%

Two-staged application of PRP in arthroscopic rotator cuff repair: a matched-pair analysis

Gwinner

Gerhardt

Haneveld

et al. 2016

Arch Orthop Trauma Surg

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“…They found that there was no enhancement in early tendon-bone healing, functional recovery, range of motion, strength or pain [80]. A level one prospective randomized double-blind study that examined two groups of 27 patients each operated for cuff tear repair (PRP group versus control group) confirmed the above results [81].…”

Section: Platelet Rich Plasma (Prp)mentioning

confidence: 96%

“…More recently, a randomized controlled trial involving 60 patients, investigated the effect of postoperative, repeated, ultrasound-guided injections of PRP to the repaired supraspinatus tendon after double-row arthroscopic repair [80]. They found that there was no enhancement in early tendon-bone healing, functional recovery, range of motion, strength or pain [80].…”

Section: Platelet Rich Plasma (Prp)mentioning

confidence: 99%

Effectiveness of Biologic Factors in Shoulder Disorders

Giotis¹,

Aryaei²,

Vasilakakos³

et al. 2017

TOORTHJ

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Background:Shoulder pathology can cause significant pain, discomfort, and loss of function that all interfere with activities of daily living and may lead to poor quality of life. Primary osteoarthritis and rotator cuff diseases with its sequalae are the main culprits. Management of shoulder disorders using biological factors gained an increasing interest over the last years. This interest reveals the need of effective treatments for shoulder degenerative disorders, and highlights the importance of a comprehensive and detailed understanding of the rapidly increasing knowledge in the field.Methods:This study will describe most of the available biology-based strategies that have been recently developed, focusing on their effectiveness in animal and clinical studies.Results:Data from in vitro work will also be briefly presented; in order to further elucidate newly acquired knowledge regarding mechanisms of tissue degeneration and repair that would probably drive translational work in the next decade. The role of platelet rich-plasma, growth factors, stem cells and other alternative treatments will be described in an evidence-based approach, in an attempt to provide guidelines for their clinical application. Finally, certain challenges that biologic treatments face today will be described as an initiative for future strategies.Conclusion:The application of different growth factors and mesenchymal stem cells appears as promising approaches for enhancing biologic repair. However, data from clinical studies are still limited, and future studies need to improve understanding of the repair process in cellular and molecular level and evaluate the effectiveness of biologic factors in the management of shoulder disorders.

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“…One of the interesting modalities is the use of PRP in the immediate post-operative period. Two different randomized control trials analyzed the use of PRP 7 and 14 days post-operatively [34,35]. Neither study was blinded nor showed a significant impact of PRP on functional outcomes or tendon integrity.…”

Section: Platelet-rich Plasma Productsmentioning

confidence: 99%

The Role of Biologic Therapy in Rotator Cuff Tears and Repairs

Charles

Christian

Cole

2018

Curr Rev Musculoskelet Med

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Platelet-rich plasma (PRP) overall has no significant impact on functional outcomes and repair integrity, but may be more advantageous in small to medium tears. Further studies should focus on leukocyte-rich versus poor preparations and the use of PRP in patients that are high risk for repair failure. Biologic and synthetic patches or augments provide mechanical stability for large and massive rotator cuff tears and decrease re-tear rates. Mesenchymal stem cells have demonstrated improved healing rates without an impact on outcomes. Cytokines and growth factors show promise in animal models, but require human trials to further evaluate. In massive or revision repairs, allograft or synthetic patch augmentation should be considered. Platelet-rich plasma may have benefit in smaller tears. Further studies are needed to evaluate the value of mesenchymal stem cells and various cytologic chemical signals.

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Do Postoperative Platelet-Rich Plasma Injections Accelerate Early Tendon Healing and Functional Recovery After Arthroscopic Supraspinatus Repair?

Abstract: After arthroscopic supraspinatus tendon repair, image-guided PRP treatment on 2 occasions does not improve early tendon-bone healing or functional recovery.

Cited by 107 publications

References 46 publications

Two-staged application of PRP in arthroscopic rotator cuff repair: a matched-pair analysis

Two-staged application of PRP in arthroscopic rotator cuff repair: a matched-pair analysis

Effectiveness of Biologic Factors in Shoulder Disorders

The Role of Biologic Therapy in Rotator Cuff Tears and Repairs

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