Do polymorphic variants of chromosomes affect the outcome of in vitro fertilization and embryo transfer treatment?

Abstract

BACKGROUNDThe aim of this study was to investigate the effect of chromosomal polymorphic variations on the outcome of IVF and embryo transfer (IVF–embryo transfer) treatment for infertile couples.METHODSDuring the period from October 2006 to December 2009, 1978 infertile couples who had received their first IVF–embryo transfer treatment cycle in our hospital were selected for this retrospective study, and the frequency of chromosomal polymorphic variations was calculated. From these, 1671 couples were selected and divided into three groups: 1402 couples with normal chromosomes (Group 1/control group), 82 couples with chromosomal polymorphic variations in only females (Group 2) and 187 couples with chromosomal polymorphic variations in only males (Group 3). The clinical pregnancy rates (CPR), early miscarriage rates and ongoing pregnancy rates after IVF–embryo transfer treatment were compared.RESULTSThere were no statistically significant differences among the three groups in implantation rates (29.37% in the control group, 29.70% in Group 2 and 31.41% in Group 3, P > 0.05) and CPR (45.86, 46.34 and 51.87%, respectively, P > 0.05). Although there was a trend toward higher first trimester pregnancy loss rates in Group 3 (male chromosomal polymorphic variations), but not in Group 2, compared with normal karyotype couples (10.31 versus 6.84%), the difference did not reach significance (P > 0.05).CONCLUSIONSChromosomal polymorphic variations appear to have no adverse effects on the outcome of IVF–embryo transfer treatment.

Reproductive outcomes in recurrent pregnancy loss associated with a parental carrier of chromosome abnormalities or polymorphisms

“…Chromosome abnormalities and polymorphisms were reported according to the International System for Human Cytogenetic Nomenclature (ISCN, 2009) (Shaffer and Slovak, 2009). It is worth noting that the pericentric inversion of chromosome 9 [inv (9)] was also considered to be as a polymorphism (Hong et al, 2011) in this study.…”

Chromosomal Heteromorphisms and Karyotype Abnormalities in Humans

“…The results of Madon et al, (2005) evaluated 842 individuals attending an IVF clinic with primary infertility or repeated miscarriages, showed polymorphic variants in 28.82% of males and 17.19% of females5. Hong et al, (2011) studied the effect of polymorphic variants in the outcome of in vitro fertilization on 1978 couples and found 182 males presented with chromosomal variations (9.2%). There was no any difference found among observed implantation rates but the incidence of first trimester pregnancy loss was higher compared to couples with normal karyotype (Hong et al, 2011).…”

“…Hong et al, (2011) studied the effect of polymorphic variants in the outcome of in vitro fertilization on 1978 couples and found 182 males presented with chromosomal variations (9.2%). There was no any difference found among observed implantation rates but the incidence of first trimester pregnancy loss was higher compared to couples with normal karyotype (Hong et al, 2011). Minocherhomji et al, (2009) in the casecontrol study identified a highly statistically significant increase in the frequency of total chromosomal variants in infertile women (28.31% vs. 15.16%) and infertile men (58.68% vs. 32.55%) as epigenetic alterations associated with the infertility phenotype8.…”

“…The chromosomal Heteromorphisms in humans have largely been reviewed by Borgaonkar, 1997;Sahin et al, 2008;Madon, 2005;Hong et al, 2011;Minocherhonji et al, 2009;Brothman et al, 2006;Chopade et al, 2012;Mau et al, 1997;Boronova et al, 2015;Akbas et al, 2010;Rao et al, 2006;Mierla and Veronica, 2012;Jeong et al, 2010;Mozdarani et al, 2007;Negvenkar et al, 2005;Dubey et al, 2005;Kosyakova et al, 2013;Ganguly and Kadam, 2014;Purandare et al, 2011;Yamini Sharad Pokale (2015) etc.…”

Chromosomal abnormalities in men with pregestational and gestational infertility in northeast China

“…It has been shown that some chromosomal polymorphisms can be associated with habitual miscarriage, developmental early pregnancy loss, stillbirth, poor maternal history and cacospermia [6]. genes associated with spermatogenesis.…”