Abstract:Background: Valproic acid (VPA) is a commonly prescribed antiepileptic drug. VPA could mediate endocrinal reproductive dysfunction on a long-term use. This study was designed to evaluate the possible protective effects of platelet rich plasma (PRP) alone and PRP in combination with folic acid (FA) in a rat model of VPA induced ovarian failure. Materials and Methods: Thirty-five adult rats were randomly divided into five equal groups and 14 female rats were used for PRP preparation as control, VPA, co-treated V… Show more
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