Do Plasma Concentrations of Apelin Predict Prognosis in Patients With Advanced Heart Failure?

Dalzell, Jonathan R.; Jackson, Colette E.; Chong, Kwok S.; McDonagh, Theresa A.; Gardner, Roy S.

doi:10.2217/bmm.14.33

Cited by 7 publications

(4 citation statements)

References 34 publications

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“…In a previous study, apelin level found to be increased at early and acute stage of HF, but progressively decreased in the advanced stages of the HF. Additionally, its predictive role has been studied in several studies [22,23]. In our study, lower serum levels of apelin were observed in the HF patients in parallel with the previous studies.…”

Section: Discussionsupporting

confidence: 89%

Serum pentraxin-3, vaspin, apelin ve troponinin dekompanze kalp yetersizliği hastalarındaki seviyeleri

Kaya

Demirbağ

2020

Turkish Journal of Clinics and Laboratory

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Aim:The aim of the present study is to evaluate the levels of these biomarkers in decompensated heart failure (HF) patients.Material and Methods: 44 decompensated HF patients and 32 healthy individuals were enrolled in the study as patient and control groups. Transthoracic echocardiography and serum troponin I, vaspin, apelin, and PTX-3 levels besides routine laboratory analysis were performed for both groups.Results: Troponin I and vaspin were higher, apelin was lower in patient group (for all, p<0.05).PTX-3 levels were higher in patient group, but it was not statistically significant (p=0.133). Troponin I and PTX-3 levels were significantly decreased (for both, p<0.05) with in-hospital-HF treatment. Vaspinand apelin levels did not show any significant change (p=0.938, p=0.121, respectively). Vaspin had an independent relationship with troponin, apelin had an independent relationship with PTX-3, troponin and apelin had independent relationship with vaspin, and finally troponin,PTX-3, and vaspin had independent relationship with apelin in decompensated HF patients. Conclusion:Troponin I and vaspin levels were elevated,and serum apelin levels were reduced in decompensated HF patients. PTX-3 levels were higher in HF patients, but it was not statistically significant. Vaspin and apelin levels did not change with HF stabilization in HF patients, but troponin I and PTX-3 levels were significantly decreased.

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Section: Discussionsupporting

confidence: 89%

Serum pentraxin-3, vaspin, apelin ve troponinin dekompanze kalp yetersizliği hastalarındaki seviyeleri

Kaya

Demirbağ

2020

Turkish Journal of Clinics and Laboratory

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“…66 However, despite this significant reduction, plasma apelin concentrations were not predictive of outcome in these patients. 70 In contrast to those findings, no significant difference in plasma apelin levels was noted between 65 patients with stable dilated cardiomyopathy (97% NYHA I/II) and normal control subjects. 71 Whether or not this disparity reflects the differing levels of disease severity in the patient groups can only be speculated at this time.…”

Section: Effect Of Hf On the Apelin-apj System In Humansmentioning

confidence: 60%

The Emerging Potential of the Apelin-APJ System in Heart Failure

Dalzell

Rocchiccioli

Weir

et al. 2015

Journal of Cardiac Failure

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“…Some of these have been reported to play important roles in the carcinogenesis of HCC. For instance, apelin has been associated with many human diseases such as type 2 diabetes, 15 advanced heart failure, 16 and obesity. 17 Apelin is a novel angiogenic factor that functions like VEGF to promote angiogenesis and tumor growth.…”

Section: Discussionmentioning

confidence: 99%

New biomarkers and therapeutic targets of human liver cancer: Transcriptomic findings

Huang

et al. 2021

BioFactors

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Hepatocellular carcinoma (HCC) is one of the most common causes of cancerrelated deaths worldwide, causing 782,000 deaths in 2018. Poor prognosis and lack of treatment are the reasons for the high mortality rate of HCC. In the current study, we conducted a comparative transcriptomic analysis, followed by a series of bioinformatics analyses, including Gene Ontology (GO) enrichment analysis and Ingenuity Pathway Analysis (IPA), aiming to unfold the detailed molecular mechanisms underlying the development of HCC. In the comparative transcriptomic analysis of 10 pairs of HCC tumoral tissues and adjunct nontumoral tissues, we identified 115 common differentially expressed genes in HCC. The GO enrichment analysis of these genes highlighted alterations in the immune response, cell proliferation and DNA damage, energetic metabolism, cell-matrix adhesion, and filament assembly in HCC. In addition, the canonical pathway analysis of IPA further showed the importance of many cell-signaling pathways involved in the carcinogenesis of HCC. The findings of this study provide a cluster of novel biomarkers and molecular therapeutic targets for HCC diagnosis and treatment.

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Do Plasma Concentrations of Apelin Predict Prognosis in Patients With Advanced Heart Failure?

Abstract: Plasma apelin concentrations do not predict medium to long-term prognosis in patients with advanced HF secondary to left ventricular systolic dysfunction.

Cited by 7 publications

References 34 publications

Serum pentraxin-3, vaspin, apelin ve troponinin dekompanze kalp yetersizliği hastalarındaki seviyeleri

Serum pentraxin-3, vaspin, apelin ve troponinin dekompanze kalp yetersizliği hastalarındaki seviyeleri

The Emerging Potential of the Apelin-APJ System in Heart Failure

New biomarkers and therapeutic targets of human liver cancer: Transcriptomic findings

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