Do parabens have the ability to interfere with steroidogenesis?

Taxvig, Camilla; Hass, Ulla; Axelstad, Marta; Boberg, Julie; Hansen, Pernille Reimer; Nellemann, Christine

doi:10.1016/j.toxlet.2008.06.679

Cited by 13 publications

(27 citation statements)

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“…As expected, PB-Pr and PB-Bu were strong estrogen agonists with PB-Bu exceeding the plateau of the E2 calibration curve. This unusually high response is unlikely to be linked with altered receptor expression as PB-Bu was reported to decrease ER expression (Okubo et al, 2001;Taxvig et al, 2008). Responses greater than E2 responses in reporter gene bioassays have previously been described as superinduction or supramaximal effects and have been attributed to post-transcriptional effects of the analyte on the reporter protein but also other assay related factors such as type of serum used, number of employed response elements or promoter's nature (Montano et al, 2010;Sotoca et al, 2010).…”

Section: Preservatives and Antimicrobialsmentioning

confidence: 96%

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Endocrine disruptor activity of multiple environmental food chain contaminants

Wielogórska

Elliott

Danaher³

et al. 2015

Toxicology in Vitro

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Section: Preservatives and Antimicrobialsmentioning

confidence: 96%

“…In vitro studies suggest that parabens can interfere with steroidogenesis (PB-Me, -Et, -Pr, -Bu) and expression of receptor proteins (PB-Bu) (Okubo et al, 2001;Taxvig et al, 2008). PB-Bu and -Pr but not -Me or -Et showed estrogenic properties in a yeast two-hybrid bioassay (Morohoshi et al, 2005;Terasaki et al, 2009).…”

Section: Preservatives and Antimicrobialsmentioning

confidence: 99%

Endocrine disruptor activity of multiple environmental food chain contaminants

Wielogórska

Elliott

Danaher³

et al. 2015

Toxicology in Vitro

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“…1,2 These compounds are suspected endocrine disruptors with potentially harmful effects on exposed offspring in animal studies. [3][4][5][6][7][8][9][10][11] The most commonly used paraben is methylparaben, but butylparaben and others are also found in many consumer products. To date, no study has examined whether these substances cross the human placenta.…”

Section: Introductionmentioning

confidence: 99%

Transplacental passage of antimicrobial paraben preservatives

Towers

Terry

Lewis

et al. 2015

J Expo Sci Environ Epidemiol

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Parabens are widely used preservatives suspected of being endocrine disruptors, with implications for human growth and development. The most common paraben found in consumer products is methylparaben. To date, no study has examined whether these substances cross the human placenta. A total of 100 study subjects (50 mother-child pairs) were enrolled at two medical institutions, serving primarily African-American and Caucasian women, respectively. A maternal blood sample was drawn on admission and a paired cord blood sample was obtained at delivery. Of the 50 mothers, 47 (94%) showed methylparaben in their blood (mean level 20.41 ng/l), and 47 in cords bloods (mean level 36.54 ng/l). There were 45 mother-child pairs where methylparaben was found in both samples. Of these, the fetal level was higher than the maternal level in 23 (51%). For butylparaben, only 4 mothers (8%) showed detectable levels (mean 40.54 ng/l), whereas 8 cord blood samples (16%) were positive (mean 32.5 ng/l). African-American mothers and infants showed higher prevalence of detectable levels (P=0.017). Methylparaben and butylparaben demonstrate transplacental passage. Additional studies are needed to examine potential differences in exposure by geography and demographics, what products are used by pregnant women that contain these preservatives, as well as any potential long-term effects in the growth and development of exposed children.

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“…An menschlichen MCF-7-Brustzellen kam es unter dem Einfluss der oben genannten Parabene zu einer Aktivierung von Genen, zu Zellproliferation, aber auch zu einer Inhibition der Aromatase, die für die Umwandlung von Androgenen in Östroge-ne verantwortlich ist [13,14]. An jeweils speziellen menschlichen Zellen der Haut, der Leber und der Nieren führten Parabene zu einer Inhibition der Östrogen-sulfotransferase (SULT), die mit einer Erhöhung der Östrogenspiegel einhergeht, zu einer Inhibition der Testosteron induzierten Transkriptionsaktivität sowie zu einer Erhöhung der Progesteronproduktion [15][16][17].…”

Section: Mutagenität Und Kanzerogenitätunclassified

“…Kawaguchi et al [18,19] be von Et-PB und Bu-PB zeigte sich bei Bu-PB eine Verminderung der mRNAExpression des Östrogenrezeptors β in fötalen Ovarien sowie eine Verminderung der mRNA-Expression des steroidogenen akuten regulatorischen Proteins und des peripheren Benzodiazepinrezeptors in den Nebennieren [17]. Im "uterotrophic assay" wurde nach subkutaner Injektion von iso-Pr-PB, Bu-PB und isoBu-PB eine Erhöhung des Uterusgewichtes festgestellt [20].…”

Section: Mutagenität Und Kanzerogenitätunclassified

Stoffmonographie für Parabene – Referenzwerte für Parabene im Urin von Erwachsenen

Umweltbundesamtes¹

2014

Bundesgesundheitsbl.

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Die Alkyl-und iso-Alkylester sowie den Benzylester der 4-Hydroxy-Benzoesäu-re (4-HBA) und deren Natriumsalze bezeichnet man als Parabene. Der Methylund der Ethylester der 4-Hydroxy-Benzoesäure werden vor allem als Konservierungsmittel in Nahrungsmitteln, Medikamenten und kosmetischen Produkten verwendet. Der Propyl-und der Butylester der 4-HBA dürfen nicht in Nahrungsmitteln eingesetzt werden [1]. Dagegen ist die Verwendung der genannten 4 Alkylester der 4-HBA und ihrer Isoformen einzeln oder im Gemisch in kosmetischen Artikeln bis zu einer Konzentration von 0,8 % erlaubt [2]. Diese Produkte sind als kontinuierliche Expositionsquellen über den Kontakt mit Haaren, Nägeln, Lippen, Augen, Mund und Schleimhäu-ten einzustufen. Aufnahme, Verteilung, Metabolismus

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Do parabens have the ability to interfere with steroidogenesis?

Cited by 13 publications

References 0 publications

Endocrine disruptor activity of multiple environmental food chain contaminants

Endocrine disruptor activity of multiple environmental food chain contaminants

Transplacental passage of antimicrobial paraben preservatives

Stoffmonographie für Parabene – Referenzwerte für Parabene im Urin von Erwachsenen

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