Do osteoporosis-related vertebral fractures precede hip fractures?

Sadat-Ali, Mir; Gullenpet, Abid Hussain; Azam, Quamar; Alomran, Ammar K.

doi:10.5312/wjo.v3.i12.235

Cited by 7 publications

(8 citation statements)

References 16 publications

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“…[ 6 ] Moreover, the incidence of fragility fractures jumped from 2.9/1000 in 1999 to 6/1000 in 2007 at an annual cost of SR4.27 billion. [ 7 , 8 ] According to El-Desouki, [ 9 ] the prevalence of postmenopausal osteoporosis in the age between 50 and 79 years was 57.5%. Another study by Oommen and AlZahrani [ 10 ] showed that 58% of Saudi women had low bone mineral density (BMD) (18% had osteoporosis and 40% had osteopenia).…”

Section: Introductionmentioning

confidence: 99%

Inflammation as a contributing factor among postmenopausal Saudi women with osteoporosis

et al. 2017

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Postmenopausal osteoporosis is an important metabolic bone disease characterized by rapid bone loss occurring in the postmenopausal period. Recently, the most prevalent form of clinically significant osteopenia and osteoporosis involves various inflammatory conditions. The aim of the study is to evaluate the association between proinflammatory markers (interleukin [IL]-1β, IL-6, TNF-α) with bone turnover markers (BTMs) in postmenopausal Saudi women with and without osteoporosis. A total of 200 postmenopausal Saudi women ≥50 years old, 100 with osteoporosis and 100 without osteoporosis (control) were recruited under the supervision of qualified physicians in King Salman Hospital and King Fahd Medical City, Riyadh, Saudi Arabia. Serum tumor necrosis factor alpha (TNF-α), IL-1, IL-4, IL-6, and parathyroid hormone (PTH) were determined using Luminex xMAP technology. N-telopeptides of collagen type I (NTx) was assessed using ELISA, 25(OH) vitamin D and osteocalcin were determined using electrochemiluminescence, serum calcium and inorganic phosphate (Pi) were measured by a chemical analyzer. Serum IL-1β, IL-6, NTx, and PTH levels in women with osteoporosis were significantly higher than controls. Although IL-4 and osteocalcin were significantly lower than controls. IL-1β and TNF-α were positively associated with NTx in osteoporosis women. TNF-α, IL-6, and TNF-α were positively correlated with IL-lβ in both groups. A significant negative correlation between osteocalcin and IL-1β in healthy women and women with osteoporosis were observed. Findings of the present study implicate a role for cytokine pattern-mediated inflammation in patients with osteoporosis.

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Section: Introductionmentioning

confidence: 99%

Inflammation as a contributing factor among postmenopausal Saudi women with osteoporosis

et al. 2017

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“…Our findings were comparable to that of Sadat-Ali et al who reported a VF in 24.7% of the patients in Saudi Arabia, with more prevalence being in females. 9 As stated by a Norwegian study in 2012, the prevalence of vertebral fractures varies according to age. The study reported the prevalence of VF in women as 3.4% when age <60 years, 11.1% with age 60-69 years and 19.2% with ≥70 years; whereas the prevalence was higher for men; 7.6% with age <60 years, 11.9% with age 60-69 years and 20.3% with ≥70 years.…”

Section: Discussionmentioning

confidence: 96%

Frequency of Vertebral Fractures in Patients presenting with Hip Fractures

Chinoy

Javed

2019

Pak J Med Sci

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Objective: To determine the frequency of vertebral fractures in patients presenting with hip fractures. Methods: This prospective study was conducted at The Indus Hospital, Karachi, from May 2018 to November 2018. All patients above 40 years presenting with hip fractures were enrolled and a dorsal lumbar lateral view radiograph was obtained to investigate for vertebral fractures. Data was entered and analyzed using SPSS. Post-stratification, Chi-square/Fisher exact test was applied as appropriate to assess the significant association. P value of ≤0.05 was considered significant. Results: Three hundred thirty five patients were enrolled. Of these, 189 (56.4%) were females and 165 (49.3%) presented with neck of femur fractures. Out of 335 hip fractures patients, 77 (23%) were found to have concomitant vertebral fractures, with 73 (96.1%) having a compression fracture. T12 was the most common vertebra involved and 68.8% of patients were asymptomatic. Co-morbid conditions were statistically significantly associated with vertebral fractures. Conclusion: There is a high prevalence of asymptomatic vertebral fractures in our population, but low compared to studies from western countries. There is a need to evaluate these fractures separately for the prevention of morbidity and mortality. doi: https://doi.org/10.12669/pjms.36.ICON-Suppl.1709 How to cite this:Chinoy MA, Javed S. Frequency of Vertebral Fractures in Patients presenting with Hip Fractures. Pak J Med Sci. Special Supplement ICON 2020. 2020;36(1):S44-S48. doi: https://doi.org/10.12669/pjms.36.ICON-Suppl.1709 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…Так, доведеними факторами ризику переломів ПВСК вважають вік старше від 65 років, належність до жі-ночої статі, попередні переломи в анамнезі, схиль-ність до падінь, сімейний анамнез переломів ПВСК, тривалий прийом глюкокортикоїдів, зловживання алкоголем, дефіцит вітаміну D та наявність деяких соматичних захворювань, зокрема паркінсонізму, цукрового діабету ІІ типу, ревматоїдного артриту та ін. [3,[13][14][15][16][17][18][19][20].…”

Section: âñòóïunclassified

“…Розподіл показника 10-річної ймовірності переломів стегнової кістки в чоловіків та жінок до перелому ПВСК вікових груп більш часто зустрічаються переломи кісток передпліччя, зокрема переломи Колліса, а переломи тіл хребців більш характерні для осіб літного віку. Обидва види переломів у декілька разів збільшують частоту по-вторних переломів, а також інших остеопоротичних пе-реломів [16][17][18][19].…”

Section: îáãîâîðåííÿunclassified

“…У 25,8 % хворих встановлено попередні переломи тіл хребців, 12,1 % -переломи плечової кістки, а в 3 хворих (4,5 %) -повторний перелом ПВСК конт-ралатеральної кінцівки. Подібні результати виявлені й у інших дослідженнях [16][17][18][19], що підтверджують гіпо-тезу щодо каскаду остеопоротичних переломів у жінок старших вікових груп.…”

Section: îáãîâîðåííÿunclassified

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Фактори Ризику Переломів Проксимального Відділу Стегнової Кістки У Хворих Старших Вікових Груп

Grygorieva¹,

Zubach²

2022

TRAUMA

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Do osteoporosis-related vertebral fractures precede hip fractures?

Abstract: We recommend that all elderly patients who go to the radiology department for a chest X-ray also have a DEXA scan and a lateral thoracic spine radiograph.

Cited by 7 publications

References 16 publications

Inflammation as a contributing factor among postmenopausal Saudi women with osteoporosis

Inflammation as a contributing factor among postmenopausal Saudi women with osteoporosis

Frequency of Vertebral Fractures in Patients presenting with Hip Fractures

Фактори Ризику Переломів Проксимального Відділу Стегнової Кістки У Хворих Старших Вікових Груп

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