Do oral contraceptives modulate an ERP response to affective pictures?

Monciunskaite, Rasa; Malden, L.; Lukstaite, I.; Rukšėnas, Osvaldas; Griksiene, Ramune

doi:10.1016/j.biopsycho.2019.107767

Cited by 13 publications

(19 citation statements)

References 88 publications

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“…Furthermore, OC users showed higher GFP (trend level) and significantly higher parieto-occipital activity compared to NC women in an earlier time window (<350 ms), pointing toward differential effects of OC use on early vs. later stages of emotional processing ( Monciunskaite et al, 2019 ). An effect of emotion regulation strategies such as reappraisal on neural reactivity was discussed, yet, no subjective stimulus evaluations were assessed to support this hypothesis ( Monciunskaite et al, 2019 ). Previous results on subjective stimulus evaluations in OC users have revealed inconsistent results.…”

Section: Introductionmentioning

confidence: 92%

“…In this only ERP study on the effects of OCs to date, the authors used a passive viewing task to examine processing of (highly) unpleasant and pleasant (i.e., erotic) as well as neutral social visual stimuli derived from the International Affective Picture System (IAPS). Monciunskaite et al (2019) reported significantly lower LPP amplitudes and global field power (GFP) in OC users compared to NC subjects in reaction to all picture categories. When comparing emotional-neutral difference scores in the LPP, however, the only significant finding was an attenuated unpleasant-neutral difference in OC users.…”

Section: Introductionmentioning

confidence: 93%

“…When comparing emotional-neutral difference scores in the LPP, however, the only significant finding was an attenuated unpleasant-neutral difference in OC users. Furthermore, OC users showed higher GFP (trend level) and significantly higher parieto-occipital activity compared to NC women in an earlier time window (<350 ms), pointing toward differential effects of OC use on early vs. later stages of emotional processing (Monciunskaite et al, 2019). An effect of emotion regulation strategies such as reappraisal on neural reactivity was discussed, yet, no subjective stimulus evaluations were assessed to support this hypothesis (Monciunskaite et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…To differentiate between earlier vs. later stages of emotional processing might be relevant in association with OC use, as a recent ERP study provided initial evidence for differential effects of OC use at different processing stages ( Monciunskaite et al, 2019 ). In this only ERP study on the effects of OCs to date, the authors used a passive viewing task to examine processing of (highly) unpleasant and pleasant (i.e., erotic) as well as neutral social visual stimuli derived from the International Affective Picture System (IAPS).…”

Section: Introductionmentioning

confidence: 99%

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Event-Related Potentials in Women on the Pill: Neural Correlates of Positive and Erotic Stimulus Processing in Oral Contraceptive Users

2022

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Background/Aims: Exposure toward positive emotional cues with – and without – reproductive significance plays a crucial role in daily life and regarding well-being as well as mental health. While possible adverse effects of oral contraceptive (OC) use on female mental and sexual health are widely discussed, neural processing of positive emotional stimuli has not been systematically investigated in association with OC use. Considering reported effects on mood, well-being and sexual function, and proposed associations with depression, it was hypothesized that OC users showed reduced neural reactivity toward positive and erotic emotional stimuli during early as well as later stages of emotional processing and also rated these stimuli as less pleasant and less arousing compared to naturally cycling (NC) women.Method: Sixty-two female subjects (29 NC and 33 OC) were assessed at three time points across the natural menstrual cycle and corresponding time points of the OC regimen. Early (early posterior negativity, EPN) and late (late positive potential, LPP) event-related potentials in reaction to positive, erotic and neutral stimuli were collected during an Emotional Picture Stroop Paradigm (EPSP). At each appointment, subjects provided saliva samples for analysis of gonadal steroid concentration. Valence and arousal ratings were collected at the last appointment.Results: Oral contraceptive users had significantly lower endogenous estradiol and progesterone concentrations compared to NC women. No significant group differences in either subjective stimulus evaluations or neural reactivity toward positive and erotic emotional stimuli were observed. For the OC group, LPP amplitudes in reaction to erotic vs. neutral pictures differed significantly between measurement times across the OC regimen.Discussion: In this study, no evidence regarding alterations of neural reactivity toward positive and erotic stimuli in OC users compared to NC was found. Possible confounding factors and lines for future research are elaborated and discussed.

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Event-Related Potentials in Women on the Pill: Neural Correlates of Positive and Erotic Stimulus Processing in Oral Contraceptive Users

2022

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“…The only included event-related potential (ERP) study was published by Monciunskaite et al (2019) and employed emotional visual stimuli when comparing women using antiandrogenic HC with NC women. The main finding was that the HC group showed blunted late ERP amplitudes to negative emotional stimuli when compared to NC women.…”

Section: Emotion Processing Fear Anxiety and Stressmentioning

confidence: 99%

The Effects of Hormonal Contraceptives on the Brain: A Systematic Review of Neuroimaging Studies

et al. 2020

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Background: Hormonal contraceptive drugs are being used by adult and adolescent women all over the world. Convergent evidence from animal research indicates that contraceptive substances can alter both structure and function of the brain, yet such effects are not part of the public discourse or clinical decision-making concerning these drugs. We thus conducted a systematic review of the neuroimaging literature to assess the current evidence of hormonal contraceptive influence on the human brain. Methods: The review was registered in PROSPERO and conducted in accordance with the PRISMA criteria for systematic reviews. Structural and functional neuroimaging studies concerning the use of hormonal contraceptives, indexed in Embase, PubMed and/or PsycINFO until February 2020 were included, following a comprehensive and systematic search based on predetermined selection criteria. Results: A total of 33 articles met the inclusion criteria. Ten of these were structural studies, while 23 were functional investigations. Only one study investigated effects on an adolescent sample. The quality of the articles varied as many had methodological challenges as well as partially unfounded theoretical claims. However, most of the included neuroimaging studies found functional and/or structural brain changes associated with the use of hormonal contraceptives. Conclusion: The included studies identified structural and functional changes in areas involved in affective and cognitive processing, such as the amygdala, hippocampus, prefrontal cortex and cingulate gyrus. However, only one study reported primary research on a purely adolescent sample. Thus, there is a need for further investigation of the implications of these findings, especially with regard to adolescent girls.

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Nociceptive Intra-epidermal Electric Stimulation Evokes Steady-State Responses in the Secondary Somatosensory Cortex

2022

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Recent studies have established the presence of nociceptive steady-state evoked potentials (SSEPs), generated in response to thermal or intra-epidermal electric stimuli. This study explores cortical sources and generation mechanisms of nociceptive SSEPs in response to intra-epidermal electric stimuli. Our method was to stimulate healthy volunteers (n = 22, all men) with 100 intra-epidermal pulse sequences. Each sequence had a duration of 8.5 s, and consisted of pulses with a pulse rate between 20 and 200 Hz, which was frequency modulated with a multisine waveform of 3, 7 and 13 Hz (n = 10, 1 excluded) or 3 and 7 Hz (n = 12, 1 excluded). As a result, evoked potentials in response to stimulation onset and contralateral SSEPs at 3 and 7 Hz were observed. The SSEPs at 3 and 7 Hz had an average time delay of 137 ms and 143 ms respectively. The evoked potential in response to stimulation onset had a contralateral minimum (N1) at 115 ms and a central maximum (P2) at 300 ms. Sources for the multisine SSEP at 3 and 7 Hz were found through beamforming near the primary and secondary somatosensory cortex. Sources for the N1 were found near the primary and secondary somatosensory cortex. Sources for the N2-P2 were found near the supplementary motor area. Harmonic and intermodulation frequencies in the SSEP power spectrum remained below a detectable level and no evidence for nonlinearity of nociceptive processing, i.e. processing of peripheral firing rate into cortical evoked potentials, was found.

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Do oral contraceptives modulate an ERP response to affective pictures?

Cited by 13 publications

References 88 publications

Event-Related Potentials in Women on the Pill: Neural Correlates of Positive and Erotic Stimulus Processing in Oral Contraceptive Users

Event-Related Potentials in Women on the Pill: Neural Correlates of Positive and Erotic Stimulus Processing in Oral Contraceptive Users

The Effects of Hormonal Contraceptives on the Brain: A Systematic Review of Neuroimaging Studies

Nociceptive Intra-epidermal Electric Stimulation Evokes Steady-State Responses in the Secondary Somatosensory Cortex

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