Do obesity and non-insulin dependent diabetes mellitus aggravate exercise-induced microproteinuria?

Hidaka, Sumi; Kaneko, Oriyoshi; Shirai, Masaki; Kojima, Kenichiro; Igarashi, Yoshiharu; Oda, Kuniyoshi; Chimata, Minoru; Nakamura, Kazuko; Nagase, Mitsumasa

doi:10.1016/s0009-8981(98)00070-9

Cited by 5 publications

(5 citation statements)

References 21 publications

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“…More than half of the patients with aceruloplasminemia (ACP), an autosomal recessive genetic disease caused by mutations in the gene encoding ceruloplasmin, have diabetes as their earliest symptom [44]. And some epidemiological studies use ceruloplasmin to indicate diabetes nephropathy progresses [45][46][47][48][49]. Each subunit of extracellular superoxide dismutase [Cu-Zn] contains a copper ion and a zinc ion, and each of the four subunits of glutathione peroxidase 6 contains a single selenium ion.…”

Section: Discussionmentioning

confidence: 99%

Metalloproteins and apolipoprotein C: candidate plasma biomarkers of T2DM screened by comparative proteomics and lipidomics in ZDF rats

Wang

et al. 2020

Nutr Metab (Lond)

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Background: Early diagnosis of type 2 diabetes mellitus (T2DM) is still difficult. Screening of plasma biomarkers has great significance of optimizing diagnosis and predicting the complications of T2DM. Methods: We used a special diet, Purina #5008, to induce diabetes in Zucker leptin receptor gene-deficient rats (fa/ fa) to establish Zucker diabetic fatty (ZDF) rats, simulating the early stage of T2DM. The differentially expressed proteins (DEP) and lipids (DEL), as potential biomarkers, were screened to compare the plasma expression levels in ZDF rats and their basic diet-fed wild-type controls (fa/+) by Tandem Mass Tags (TMT) and liquid chromatographytandem mass spectrometry. Results: These two groups had different plasma proteins and lipids profiles consisting of 84 DEPs and, 179 DELs identified in the positive ion mode and 178 DELs in the negative ion mode, respectively. Enrichment analysis of these different indicators showed that oxidative stress, insulin resistance and metabolic disorders of glycan and lipid played an important role in generating the difference. Some markers can be used as candidate biomarkers in prediction and treatments of T2DM, such as ceruloplasmin, apolipoprotein C-I, apolipoprotein C-II and apolipoprotein C-IV. Conclusion: These plasma differences help to optimize the diagnosis and predict the complications of T2DM, although this remains to be verified in the crowd. Trace elements related-metalloproteins, such as ceruloplasmin, and lipid metabolism and transport-related apolipoprotein C are expected to be candidate biomarkers of T2DM and should be given more attention.

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Section: Discussionmentioning

confidence: 99%

Metalloproteins and apolipoprotein C: candidate plasma biomarkers of T2DM screened by comparative proteomics and lipidomics in ZDF rats

Wang

et al. 2020

Nutr Metab (Lond)

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“…Increased urinary beta-2-microglobulin excretion is a sensitive marker of proximal tubular dysfunction [15]. Prospective data regarding the association between markers of renal tubular dysfunction and obesity are limited and so far controversial [11,26,27], and data pertaining to children are very scarce.…”

Section: Introductionmentioning

confidence: 99%

Effect of childhood obesity and obesity-related cardiovascular risk factors on glomerular and tubular protein excretion

et al. 2005

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According to our results, clinically healthy obese children have a higher degree of albuminuria and beta-2-microglobulinuria than normal weight children, indicating early renal glomerular and tubular dysfunction as a consequence of childhood obesity. The urinary albumin/creatinine ratio in the obese children was associated with certain metabolic derangements linked to obesity, and also with the clustering of features of the metabolic syndrome.

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“…More than half of the patients with aceruloplasminemia (ACP), an autosomal recessive genetic disease caused by mutations in the gene encoding ceruloplasmin, have diabetes as their earliest symptom [44]. And some epidemiological studies use ceruloplasmin to indicate diabetes nephropathy progresses [45][46][47]. Each subunit of extracellular superoxide dismutase [Cu-Zn] contains a copper ion and a zinc ion, and each of the four subunits of glutathione peroxidase 6 contains a single selenium ion.…”

Section: Discussionmentioning

confidence: 99%

Metalloproteins and apolipoprotein C: candidate plasma biomarkers of T2DM screened by comparative proteomics and lipidomics in ZDF rats

Wang

et al. 2020

Preprint

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Background Early diagnosis of type 2 diabetes mellitus (T2DM) is still difficult. Screening of plasma biomarkers has great significance of optimizing diagnosis and predicting the complications of T2DM. Methods We used a special diet, Purina #5C08, to induce diabetes in Zucker leptin receptor gene-deficient rats (fa/fa) to establish Zucker diabetic fatty (ZDF) rats, simulating the early stage of T2DM. The differentially expressed proteins (DEP) and lipids (DEL), as potential biomarkers, were screened to compare the plasma expression levels in ZDF rats and their basic diet-fed wild-type controls (fa/+) by Tandem Mass Tags (TMT) and liquid chromatography-tandem mass spectrometry. Results These two groups had different plasma proteins and lipids profiles consisting of 84 DEPs and, 179 DELs identified in the positive ion mode and 178 DELs in the negative ion mode, respectively. Enrichment analysis of these different indicators showed that oxidative stress, insulin resistance and metabolic disorders of glycan and lipid played an important role in generating the difference. Some markers can be used as candidate biomarkers, such as ceruloplasmin, apolipoprotein C-I, apolipoprotein C-II, apolipoprotein C-IV, etc., in prediction and treatments of T2DM. Conclusion These plasma differences help to optimize the diagnosis and predict the complications of T2DM, although this remains to be verified in the crowd. Trace elements related-metalloproteins, such as ceruloplasmin, and lipid metabolism and transport-related apolipoprotein C are expected to be candidate biomarkers of T2DM and should be given more attention.

show abstract

Do obesity and non-insulin dependent diabetes mellitus aggravate exercise-induced microproteinuria?

Cited by 5 publications

References 21 publications

Metalloproteins and apolipoprotein C: candidate plasma biomarkers of T2DM screened by comparative proteomics and lipidomics in ZDF rats

Metalloproteins and apolipoprotein C: candidate plasma biomarkers of T2DM screened by comparative proteomics and lipidomics in ZDF rats

Effect of childhood obesity and obesity-related cardiovascular risk factors on glomerular and tubular protein excretion

Metalloproteins and apolipoprotein C: candidate plasma biomarkers of T2DM screened by comparative proteomics and lipidomics in ZDF rats

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