Do Obese Bacteria Make us “Want them”? Intestinal Microbiota, Mesocorticolimbic Circuit and Non-Homeostatic Feeding

Urrutia-Piñones, Jocelyn; Illanes-González, Javiera; López-Aguilera, Alejandra; Julio–Pieper, Marcela; Bravo, Javier A.

doi:10.1007/s40473-018-0161-x

Cited by 3 publications

(3 citation statements)

References 72 publications

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“…A re-appraisal of maladaptive or aberrant or unhealthy eating habits/dietary patterns, across the spectrum from overly restrictive to uncontrolled, triggered by psychedelic therapy ( Foldi et al, 2020 ; Spriggs et al, 2021 a, 2021 b) could harness the reciprocal homeostatic and reward-processing cycles of the diet-MGB axis ( Berding et al, 2021 ; Boscaini et al, 2022 ; Marx et al, 2021 ; Urrutia-Piñones et al, 2018 ). Similarly, given the overlapping relationship between diet, exercise and the MGB axis, psychedelic therapy-induced reappraisal of maladaptive physical activity patterns could be primed by optimal diet-MGB axis signalling before psychedelic therapy and then maintained after psychedelic therapy ( Barton et al, 2018 ; Clarke et al, 2014 ; Clauss et al, 2021 ; O'Sullivan et al, 2015 ).…”

Section: Mgb Axis and Rewardmentioning

confidence: 99%

Seeking the Psilocybiome: Psychedelics meet the microbiota-gut-brain axis

Kelly¹,

Clarke²,

Harkin³

et al. 2023

International Journal of Clinical and Health Psychology

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Section: Mgb Axis and Rewardmentioning

confidence: 99%

Seeking the Psilocybiome: Psychedelics meet the microbiota-gut-brain axis

Kelly¹,

Clarke²,

Harkin³

et al. 2023

International Journal of Clinical and Health Psychology

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“…Previous studies have shown that the gut microbiota is also associated with energy intake, material metabolism, and insulin sensitivity [ 526 , 600 ]. Therefore, are there more “obese bacteria” that promote the development of CVDs by increasing energy intake from food in patients with CVDs than in healthy people [ 601 ]? Does excessive calorie intake and lack of physical exercise promote the development of CVDs by reshaping gut microbiota [ 492 ]?…”

Section: Perspectivementioning

confidence: 99%

The role of the gut microbiota in health and cardiovascular diseases

Wang

Zhang

et al. 2022

Mol Biomed

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The gut microbiota is critical to human health, such as digesting nutrients, forming the intestinal epithelial barrier, regulating immune function, producing vitamins and hormones, and producing metabolites to interact with the host. Meanwhile, increasing evidence indicates that the gut microbiota has a strong correlation with the occurrence, progression and treatment of cardiovascular diseases (CVDs). In patients with CVDs and corresponding risk factors, the composition and ratio of gut microbiota have significant differences compared with their healthy counterparts. Therefore, gut microbiota dysbiosis, gut microbiota-generated metabolites, and the related signaling pathway may serve as explanations for some of the mechanisms about the occurrence and development of CVDs. Several studies have also demonstrated that many traditional and latest therapeutic treatments of CVDs are associated with the gut microbiota and its generated metabolites and related signaling pathways. Given that information, we summarized the latest advances in the current research regarding the effect of gut microbiota on health, the main cardiovascular risk factors, and CVDs, highlighted the roles and mechanisms of several metabolites, and introduced corresponding promising treatments for CVDs regarding the gut microbiota. Therefore, this review mainly focuses on exploring the role of gut microbiota related metabolites and their therapeutic potential in CVDs, which may eventually provide better solutions in the development of therapeutic treatment as well as the prevention of CVDs.

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“…EECs are able to secrete peptides that regulate satiety and appetite in response to bacterial metabolites (Raybould, 2010), demonstrating that the microbiota composition and richness might be responsible for host eating behaviour and appetite (Alcock et al, 2014;Urrutia-Piñones et al, 2018).…”

Section: Food Reward Signallingmentioning

confidence: 99%

Microbiota‐gut‐brain axis as a regulator of reward processes

García-Cabrerizo

Carbia

Riordan

et al. 2021

Journal of Neurochemistry

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The reward system is a set of neuronal structures responsible for the processing of a number of psychological components, such as 'wanting', 'liking' and associative learning (Berridge & Robinson, 2003).These three processes occur together, 'wanting' dominates the initial appetitive phase, 'liking' dominates the consummatory phase, and learning occurs through the reward-behavioural cycle (Berridge et al., 2016). Both phenomena are underpinned by different brain circuits and neurotransmitter systems. The 'wanting' component is largely controlled by the dopaminergic system, whereas the 'liking' component is thought to be more mediated by opioid and GABAergic systems (Berridge & Robinson, 2003). The neural circuitry constituting the anatomical and neurochemical substrate for reward and pleasure was described several decades ago by Olds and Milner, who, after implanting electrodes in certain areas of the central nervous system (CNS) and administering electrical microstimuli, demonstrated a pleasure response in the animals (Olds and Milner 1954).Following this, it was proposed that the monoaminergic activity could underlie the neurochemical basis of pleasure, with the monoaminergic system playing an important role in drug reinforcement

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Do Obese Bacteria Make us “Want them”? Intestinal Microbiota, Mesocorticolimbic Circuit and Non-Homeostatic Feeding

Cited by 3 publications

References 72 publications

Seeking the Psilocybiome: Psychedelics meet the microbiota-gut-brain axis

Seeking the Psilocybiome: Psychedelics meet the microbiota-gut-brain axis

The role of the gut microbiota in health and cardiovascular diseases

Microbiota‐gut‐brain axis as a regulator of reward processes

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