Abstract:Background and aims: The PI3K protein kinase B (PI3K/Akt) signaling pathway has crucial roles in insulin signaling and other endocrine disorders. It is the purpose of this study to validate the association of PCOS with PI3K/AKT pathway target genes, miR486-5p, and miR483-5p as well as to evaluate the outcome of metformin on the pathogenesis of PCOS.
Methods: This case-controlled study included 3 subject groups: twenty healthy females (control group), twenty PCOS females before treatment, and twenty PCOS femal… Show more
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