Do myopes have deficits in peripheral flicker sensitivity?

Hathibelagal, Amithavikram R.; Manoharan, Manoj K.; Verkicharla, Pavan K.

doi:10.1016/j.optom.2021.01.003

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…Previous studies have found a decrease in the CFF value in patients with macular diseases, including AMD and DR. 40 , 41 , 42 , 58 This decrease may be attributed to the loss of retinal ganglion cells. Other studies have found alterations in CFF values in high myopia eyes, 45 , 59 indicating that CFF tests were sensitive enough to discern macular diseases and structural changes in the retina. Shankar et al.…”

Section: Current Research Of Cff In Cataractsmentioning

confidence: 87%

The theory of critical flicker fusion frequency and its application in cataracts

Xu¹,

Fu²,

Qi³

et al. 2023

Advances in Ophthalmology Practice and Research

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Section: Current Research Of Cff In Cataractsmentioning

confidence: 87%

The theory of critical flicker fusion frequency and its application in cataracts

Xu¹,

Fu²,

Qi³

et al. 2023

Advances in Ophthalmology Practice and Research

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“…These findings are consistent with the previous mfERG investigations in different refractive errors that also reported significantly smaller mfERG amplitudes in myopes, which were associated with the degree of myopia, axial length and retinal eccentricity. 24 The previous studies reported that the reduced mfERG responses in myopes were related to reduced retinal thickness profile, 52 cone photoreceptor density, 50,51 retinal ganglion cell density, 53 monocular flicker modulation thresholds 54 and also localised structural alterations in eyes to increased…”

Section: Discussionmentioning

confidence: 99%

Association between relative peripheral refraction and corresponding electro‐retinal signals

Gupta

Chakraborty

Verkicharla

2023

Ophthalmic Physiologic Optic

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Considering the potential role of the peripheral retina in refractive development and given that peripheral refraction varies significantly with increasing eccentricity from the fovea, we investigated the association between relative peripheral refraction (RPR) and corresponding relative peripheral multifocal electroretinogram (mfERG) responses (electro-retinal signals) from the central to the peripheral retina in young adults. Methods: Central and peripheral refraction using an open-field autorefractor and mfERG responses using an electrophysiology stimulator were recorded from the right eyes of 17 non-myopes and 24 myopes aged 20-27 years. The relative mfERG N1, P1 and N2 components (amplitude density and implicit time) of a mfERG waveform were compared with the corresponding RPR measurements at the best-matched eccentricities along the principal meridians, that is at the fovea (0°), horizontal (±5°, ±10° and ± 25°) and vertical meridians (±10° and ± 15°). Results:The mean absolute mfERG N1, P1 and N2 amplitude densities (nV/deg 2 ) were maximum at the fovea in both non-myopes (N1: 57.29 ± 14.70 nV/deg 2 , P1: 106.29 ± 24.46 nV/deg 2 , N2: 116.41 ± 27.96 nV/deg 2 ) and myopes (N1: 56.25 ± 15.79 nV/ deg 2 , P1: 100.79 ± 30.81 nV/deg 2 , N2: 105.75 ± 37.91 nV/deg 2 ), which significantly reduced with increasing retinal eccentricity (p < 0.01). No significant association was reported between the RPR and corresponding relative mfERG amplitudes at each retinal eccentricity (overall Pearson's correlation, r = −0.25 to 0.26, p ≥ 0.09). In addition, the presence of relative peripheral myopia or hyperopia at extreme peripheral retinal eccentricities did not differentially influence the corresponding relative peripheral mfERG amplitudes (p ≥ 0.24). Conclusions: Relative peripheral mfERG signals are not associated with corresponding RPR in young adults. It is plausible that the electro-retinal signals may respond to the presence of absolute hyperopia (and not relative peripheral hyperopia), which requires further investigation.

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“…Other possible reasons for reduced visual acuity in myopes in the absence of any pathologic myopia lesions are: (a) contrast sensitivity, 35 (b) higher-order aberrations, 21,22,[36][37][38] (c) minification of the retinal image and the poor optical quality of the spectacle lenses, 16,17 (d) crowding effect that is more evident with increasing myopia, 15,39,40 (e) fixation stability that with visual function and affects performance of a visually demanding task, 41 (f) an error in the magnitude or amplitude of microsaccades or the amplitude of slow drifts that may affect the dynamics and the spatial allocation of selective attention contributing to the reduction in visual acuity in amblyopia, 42,43 (g) larger spacing between the photoreceptors and neurons in the myopic retina resulting in neural deficits and reduced sensitivity in myopes compared with emmetropes 17,21,22,36,44 and (h) reduced directionality of photoreceptors (Stiles-Crawford effect) in myopes due to axial elongation. 45 In the presence of pathologic myopia lesions, we found that a tessellated fundus, CRA and CNV were associated with reduced visual acuity in myopes, which corroborates the findings of previous studies.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with reduced visual acuity in myopes with and without ocular pathologies after optical correction

Manoharan

Thakur

Dellhi

et al. 2022

Ophthalmic Physiologic Optic

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Purpose: Considering that a certain proportion of high myopes have reduced visual acuity even after full optical correction, this study aimed to investigate the association between various refractive error components (sphere, cylinder and axis orientation) and reduced visual acuity in individuals with low to high myopia with and without pathologic myopia lesions. Methods:We analysed data from randomly selected eyes of 11,258 individuals with myopia (mean ± SD spherical equivalent (SE) −3.2 ± 2.9D; range: −0.5D to −21.5D). In total, 10,528 individuals had no pathologic myopia lesions. Sphere, cylinder and SE refraction were classified into mild, moderate and high categories.Astigmatism was defined as with-the-rule, against-the-rule or oblique based on the axis orientation. Reduced best-corrected visual acuity was defined as ≥0.18 logMAR. Logistic regression was performed to test factors associated with reduced visual acuity with and without pathologic myopia lesions.Result: Overall, 6.4% (N = 720/11,258) of myopes had reduced best-corrected visual acuity. High sphere (≤−6.0D; Odd ratios [OR]: 16.1; 95% CI: 2.1-126.5), high cylinder (<−2.0 DC; OR: 2.5; 95% CI: 1.8-3.4), against-the-rule (OR: 1.5; 95% CI: 1.1-2.0) and oblique astigmatism (OR: 1.6; 95% CI: 1.2-2.1) were significantly (p ≤ 0.008) associated with reduced visual acuity in the absence of pathologic myopia lesions. Both moderate SE and high myopic SE were also associated with reduced visual acuity.In the presence of pathologic myopia lesions, tessellated fundus (OR: 6.9; 95% CI: 3.5-14.1), chorioretinal atrophy (OR: 7.7; 95% CI: 2.6-19.9) and choroidal neovascularisation (OR: 37.4; 95% CI: 3.3-419.3) were significantly (p ≤ 0.003) associated with reduced visual acuity. Conclusion:Even after full optical correction, both refractive components and pathologic myopia lesions can independently cause reduced visual acuity, regardless of the degree of myopia. K E Y W O R D S myopic lesions, ocular pathologies, reduced vision, risk factors, visual acuityHow to cite this article: Manoharan MK, Thakur S, Dellhi S, Verkicharla PK. Factors associated with reduced visual acuity in myopes with and without ocular pathologies after optical correction.

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Do myopes have deficits in peripheral flicker sensitivity?

Cited by 3 publications

References 29 publications

The theory of critical flicker fusion frequency and its application in cataracts

The theory of critical flicker fusion frequency and its application in cataracts

Association between relative peripheral refraction and corresponding electro‐retinal signals

Factors associated with reduced visual acuity in myopes with and without ocular pathologies after optical correction

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