Do MYO9B genetic variants predispose to coeliac disease? An association study in a cohort of South Italian children

Frequency of MYO9B polymorphisms in celiac patients and controls

“…As for rs1457092 and concurring with Monsuur's data, we found that the CC genotype is a protective factor (OR 0.07 [0.0-0.3] p = 0.0001), however, this differs from data by Sanchez et al (21). The similarities and differences described make evident the large generic variability present in the global population.…”

“…(11). However, other recent publications found no association between this polymorphism and CD (12,20,21,(24)(25)(26)(27).…”

“…DNA concentration was determined with the quantification NAN-ODROP equipment (Thermo Fisher Scientific, USA). Determination of rs2305767 C/T, rs1457092 A/C and rs2305764 A/G (11,(18)(19)(20)(21) in MYO9B was performed using Taqman probes.…”

The myosin superfamily at a glance

“…Although M9b has been linked to a number of intestinal disease states, there is some controversy over these genetic associations. Two studies implicated this motor protein in celiac disease (Monsuur, 2005;Wolters, 2007), but other data indicate that this association is absent in a number of populations Amundsen, 2006a;Nunez, 2006;Cirillo, 2007;Koskinen, 2008). Furthermore, whereas M9b has been linked to inflammatory bowel diseases (Latiano, 2008;Nunez, 2007;van Bodegraven, 2006;Cooney, 2009), this might not be the case for all cohorts (Amundsen, 2006b), which adds to the debate about the function of this motor protein.…”

No association observed between schizophrenia and non‐HLA coeliac disease genes: Integration with the initial MYO9B association with coeliac disease

“…This also allowed us to include more recent studies and the fuller transmission data of Giordano et al [2006]. Where exact allele counts were not provided, they were estimated from published frequencies [Monsuur et al, 2005;Amundsen et al, 2006;Giordano et al, 2006;Hunt et al, 2006;N uñez et al, 2006;Cirillo et al, 2007;S anchez et al, 2007;Latiano et al, 2008]. As the Q P-value is <0.05 (Table V), a random effect model is the most appropriate means of synthesizing the overall effect size.…”