Do mesenchymal stromal cell infusions advance the understanding and treatment options of FLNA‐associated pulmonary disease?

Yonker, Lael M.; Hawley, Megan H.; Kinane, T. Bernard

doi:10.1002/ppul.24570

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…Stem cell therapy represents a prospective approach in regenerative medicine for the repair, replacement, and rejuvenation of tissue [ 1 , 2 ]. Mesenchymal stromal cells (MSCs) expanded in vitro have been proposed as potential therapy to treat congenital and acquired lung diseases [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. MSCs are multipotent cells that can differentiate into multiple tissue-forming cell lineages, such as osteoblasts, adipocytes, chondrocytes, tenocytes, and myocytes.…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal Stromal Cells for the Treatment of Interstitial Lung Disease in Children: A Look from Pediatric and Pediatric Surgeon Viewpoints

Pelizzo

Silvestro

Avanzini

et al. 2021

Cells

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Mesenchymal stromal cells (MSCs) have been proposed as a potential therapy to treat congenital and acquired lung diseases. Due to their tissue-regenerative, anti-fibrotic, and immunomodulatory properties, MSCs combined with other therapy or alone could be considered as a new approach for repair and regeneration of the lung during disease progression and/or after post- surgical injury. Children interstitial lung disease (chILD) represent highly heterogeneous rare respiratory diseases, with a wild range of age of onset and disease expression. The chILD is characterized by inflammatory and fibrotic changes of the pulmonary parenchyma, leading to gas exchange impairment and chronic respiratory failure associated with high morbidity and mortality. The therapeutic strategy is mainly based on the use of corticosteroids, hydroxychloroquine, azithromycin, and supportive care; however, the efficacy is variable, and their long-term use is associated with severe toxicity. The role of MSCs as treatment has been proposed in clinical and pre-clinical studies. In this narrative review, we report on the currently available on MSCs treatment as therapeutical strategy in chILD. The progress into the therapy of respiratory disease in children is mandatory to ameliorate the prognosis and to prevent the progression in adult age. Cell therapy may be a future therapy from both a pediatric and pediatric surgeon’s point of view.

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