Do men with mild erectile dysfunction have the same risk factors as the general erectile dysfunction clinical trial population?

Abstract

versus 55 ± 11 (18-89) years, body mass index was 29 ± 5 (20-48) versus 28 ± 5 (11-64) kg/m 2 and ED duration was 3.5 ± 3.2 ( < 1-18) versus 4.6 ± 4.7 ( < 1-45) years.• The prevalence of comorbidities associated with ED was similar (hypertension 26.1% ( n = 46) vs 32.8%; diabetes mellitus 13.6% ( n = 24) vs 22.1%; dyslipidemias 12.5% ( n = 22) vs 11.7%; hypercholesterolemia 12.5% ( n = 22) vs 9.5%; gastro-esophageal reflux disease 10.8% ( n = 19) vs 6.0%; benign prostatic hyperplasia 9.7% ( n = 17) vs 9.9%; depression 6.3% ( n = 11) vs 5.6%; and anxiety 4.0% ( n = 7) vs 1.6%), as was the rate of use of medications for those comorbidities. CONCLUSIONS• Men with mild ED have similar risk factors to a general ED clinical trial population. Thus, mild ED is an important indicator of risk for underlying disease associated with ED.• Inquiry into ED should be part of routine clinical evaluation to facilitate rapid identification and early intervention.• Men complaining of mild ED should be evaluated adequately for underlying cardiovascular risk. KEYWORDS erectile dysfunction, epidemiology, demography, risk factors, comorbidityWhat's known on the subject? and What does the study add? Erectile dysfunction (ED) that is mild (score of 22-25 on the Erectile Function domain of the International Index of Erectile Function) is often overlooked in clinical practice because men do not seek treatment or because healthcare professionals consider complaints of mild ED to be irrelevant and fail to evaluate such patients. ED is associated with increased prevalence of diseases that accompany ageing, including cardiovascular disease and diabetes, but there do not appear to be any published epidemiological data on the prevalence or risk for such diseases in populations of men with mild ED. Greater understanding of this population's underlying risk for diseases associated with ED may highlight the importance of earlier diagnosis and treatment.In this study, the underlying risk for diseases associated with ED is compared between the first large population of men with mild ED for whom demographic and baseline data have been reported and a manufacturer's database of men (representing the general ED clinical trial population), which is the largest population of men with ED for whom demographic and baseline data have been reported. The findings show that men with mild ED may have substantial underlying risk for diseases associated with ED, including hypertension, diabetes, and lipid disorders.Study Type -Symptom prevalence (prospective cohort/RCT) Level of Evidence 1b OBJECTIVE• To compare the underlying risk for diseases associated with erectile dysfunction (ED; i.e. cardiovascular disease and diabetes) in a population of men with mild ED relative to a general ED clinical trial population. PATIENTS AND METHODS• Men enrolled in a randomized, doubleblind placebo-controlled (DBPC) trial of sildenafil for the treatment of mild ED were compared with a database of men enrolled in 67 of the manufacturer's other DBPC sildenafil trials.• The main outc...

Basaal wetenschappelijk bewijs voor de link tussen erectiele disfunctie en cardiometabole disfunctie

“…De erectiele functie en het cardiovasculaire systeem worden op gelijke wijze gereguleerd door het sympathische en parasympathische deel van het autonome zenuwstelsel. Vasculaire ED kan helpen bij het ontdekken van CVZ in een vroege fase [5], maar of ED ten gevolge van autonome disregulatie een toekomstige cardiovasculaire autonome neuropathie kan voorspellen, blijft nog onduidelijk.…”

“…Cardiovasculaire en metabole ziekten (CVMZ) hebben een zeer sterke link met ED, en talrijke studies hebben deze associatie aangetoond [4,5]. Zo toonde Montorsi in 2003 aan dat ED vooraf kan gaan aan cardiovasculaire ziekten (CVZ): bij 300 patiënten met acute pijn op de borst met vervolgens angiografisch bewezen atherosclerose van de coronaire arteriën, was reeds in 49 % van de gevallen vooraf sprake van ED en in 67 % van de gevallen trad ED op voorafgaand aan klachten van CVZ [4].…”

Should men with mild erectile dysfunction be closely evaluated for cardiovascular diseases in the Korean population?

“…In contrast, some studies have demonstrated that the prevalence of cardiovascular comorbidities in men with mild ED was comparable to that in men with more severe ED [8,9,11]. Despite the potential relationships between ED and cardiovascular diseases, men with mild ED do not appear to seek or receive appropriate medical care because of attitudes, beliefs, or other psychological factors [11,12]. More importantly, investigations have been scarce for the association between mild ED and cardiovascular diseases [11].…”

“…One study reported that only moderate-to-severe ED, but not mild ED, was associated with increased risk for coronary heart diseases or cerebrovascular stroke within 10 years [3]. In contrast, some studies have demonstrated that the prevalence of cardiovascular comorbidities in men with mild ED was comparable to that in men with more severe ED [8,9,11]. Despite the potential relationships between ED and cardiovascular diseases, men with mild ED do not appear to seek or receive appropriate medical care because of attitudes, beliefs, or other psychological factors [11,12].…”

“…Despite the potential relationships between ED and cardiovascular diseases, men with mild ED do not appear to seek or receive appropriate medical care because of attitudes, beliefs, or other psychological factors [11,12]. More importantly, investigations have been scarce for the association between mild ED and cardiovascular diseases [11]. Furthermore, the prevalence of cardiovascular comorbidities had not been compared among patients with mild ED and patients with more severe ED in Asian populations.…”