Do men become infertile after having sexually transmitted urethritis? An epidemiologic examination

Ness, Roberta B.; Marković, Nina; Carlson, Catherine L.; Coughlin, Michael T.

doi:10.1016/s0015-0282(97)81502-6

Cited by 74 publications

(33 citation statements)

References 56 publications

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“…17 Ascending infection in men can lead to epididymitis, but the effects of this on future fertility are not clear. 18 There is not thought to be any lasting immunity following a chlamydia infection that has resolved spontaneously or been treated with antibiotics, so repeated infections can occur. 19 There is much ongoing debate about the natural history of chlamydia and the frequency of reproductive tract complications following lower genital tract infection.…”

Section: Chlamydia and Its Clinical Consequencesmentioning

confidence: 99%

Epidemiological, social, diagnostic and economic evaluation of population screening for genital chlamydial infection

Low

McCarthy²,

Macleod³

et al. 2007

Health Technol Assess

133

179

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Section: Chlamydia and Its Clinical Consequencesmentioning

confidence: 99%

Epidemiological, social, diagnostic and economic evaluation of population screening for genital chlamydial infection

Low

McCarthy²,

Macleod³

et al. 2007

Health Technol Assess

133

179

View full text Add to dashboard Cite

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“…There are clinical concerns about long-term sequelae including infertility, prostatitis, and strictures. [11][12][13][14] Cases related to sexually transmitted infection (STI) present opportunities to screen for infection and to offer treatment, and for partner notification, which should not be missed. The National Strategy for Sexual Health and HIV has, since 2001, recommended a greater role for primary care providers in the care of STIs.…”

Section: Introductionmentioning

confidence: 99%

Management of epididymo-orchitis in primary care: results from a large UK primary care database

Nicholson¹,

Rait²,

Murray‐Thomas³

et al. 2010

Br J Gen Pract

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BackgroundEpididymo-orchitis is a common urological presentation in men but recent incidence data are lacking. Guidelines for management recommend detailed investigation and treatment for sexually transmitted pathogens, such as Chlamydia trachomatis. Data from secondary care indicate that these guidelines are poorly followed. It is not known how epididymo-orchitis is managed in UK general practice. AimTo estimate the incidence of cases of epididymoorchitis seen in UK general practice, and to describe their management. Design of studyCohort study. Setting UK general practices contributing to the General Practice Research Database (GPRD). MethodMen, aged 15-60 years, consulting with a first episode of epididymo-orchitis between 30 June 2003 and 30 June 2008 were identified. All records within 28 days either side of the diagnosis date were analysed to describe the management of these cases (including location) and to compare this management with guidelines. ResultsA total of 12 615 patients with a first episode of epididymo-orchitis were identified. The incidence was highest in 2004-2005 (25/10 000) and declined in the later years of the study. Fifty-seven per cent (6943) of patients were managed entirely within general practice. Of these, over 92% received an antibiotic, with ciprofloxacin being the most common one prescribed. Only 18% received a prescription for doxycycline. Most men, including those under 35 years, had no investigation recorded and fewer than 3% had a test for chlamydia. ConclusionThese results indicate low rates of specific testing and treatment for sexually transmitted infections in males who attend general practice with symptoms of epididymo-orchitis. There is a need for further research to understand the pattern of care delivered in general practice.

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“…e infertilità maschile tanto che alcuni autori concludono che forse il solo aspetto importante di un'infezione nell'uomo è che costituisce un reservoir aumentando le possibilità di infezione nella donna. Molti studi hanno cercato di correlare la presenza di markers sierologici di infezione pregressa con la qualità dello sperma, in realtà non sono state descritte differenze significative tra uomini con pregressa infezione e non (63,83). Altri, pur confermando ciò, mettono in evidenza una stretta associazione tra assenza di concepimento e presenza di IgG anti Chlamydia nell'uomo indipendentemente dalla qualità dello sperma (57).…”

Section: Infertilità Maschileunclassified

Genital Chlamydia trachomatis infections

Latino¹,

Maria²,

Caneparo³

et al. 2008

Microbiol Med

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BIOLOGIAChlamydia trachomatis (C.t.) è un parassita endocellulare obbligato che appartiene alla famiglia delle Chlamydiaceae comprendente due generi, Chlamydia e Chlamydophila, e nove specie. Di queste solo tre sono responsabili di infezioni nell'uomo: C. trachomatis, appartenente al genere Chlamydia e C. pneumoniae e C. psittaci appartenenti al genere Chlamydophila (10). Mentre le infezioni da C. pneumoniae e C. psittaci interessano prevalentemente l'apparato respiratorio, C.t. ha un particolare tropismo per l'epitelio genitale e congiuntivale. Sulla base delle differenze antigeniche, sono stati identificati diciannove serovars di C.t.: i serovars A, B, Ba e C sono responsabili di patologie a carico dell'occhio e sono associati al tracoma endemico, i serovars D, Da, E, F, G, Ga, H, I, Ia e K sono più comunemente associati ad infezioni del tratto genitale a trasmissione sessuale, alle congiuntiviti da inclusi o alle polmoniti neonatali, infine i serovars L1, L2, L2a e L3 sono associati al linfogranuloma venereo (14).Il parassitismo endocellulare obbligato è spiegato dal fatto che C.t., incapace di sintetizzare ATP, deve necessariamente utilizzare quello della cellula ospite. Il ciclo vitale di Chlamydia è di tipo dimorfico. La forma infettante è rappresentata dal corpo elementare (CE), di aspetto rotondeggiante e uniformemente denso al microscopio elettronico, in grado

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Do men become infertile after having sexually transmitted urethritis? An epidemiologic examination

Cited by 74 publications

References 56 publications

Epidemiological, social, diagnostic and economic evaluation of population screening for genital chlamydial infection

Epidemiological, social, diagnostic and economic evaluation of population screening for genital chlamydial infection

Management of epididymo-orchitis in primary care: results from a large UK primary care database

Genital Chlamydia trachomatis infections

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