Do low‐serum vitamin E levels increase the risk of Alzheimer disease in older people? Evidence from a meta‐analysis of case‐control studies

Dong, Yonghai; Chen, Xiaodan; Liu, Yun; Yan, Siyu; Chen, Ting; Xu, Lei; Li, Meng; Guan, Xiaohui

doi:10.1002/gps.4780

Cited by 23 publications

(17 citation statements)

References 33 publications

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“…Several studies have shown that this vitamin may also have independent effects on cognitive function, though results are not entirely consistent [ 59 ]. Low plasma vitamin E has been linked to poor memory [ 60 ] and the odds of having Alzheimer’s disease (AD) [ 61 ]. However, vitamin E supplementation has not been beneficial in preventing the onset of AD or dementia in clinical trials [ 62 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Patterns and Cognitive Function among Older Community-Dwelling Adults

et al. 2018

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Diet may be an important modifiable risk factor for maintenance of cognitive health in later life. This study aimed at examining associations between common dietary indices and dietary patterns defined by factor analysis and cognitive function in older community-dwelling adults. Dietary information for 1499 participants from the Rancho Bernardo Study was collected in 1988–1992 and used to calculate the alternate Mediterranean diet score, Alternate Healthy Eating Index (AHEI)-2010 score and factor scores derived from factor analysis of nutrients. Global cognitive function, executive function, verbal fluency and episodic memory were assessed at approximate four-year intervals from 1988–2016. Linear mixed models were used to examine associations between dietary patterns and cognitive trajectories. Estimates for the highest vs. lowest tertile in models adjusting for age, sex, education, energy intake, lifestyle variables and retest effect showed greater adherence to the Mediterranean score was associated with better baseline global cognitive function (β (95% CI) = 0.33 (0.11, 0.55)). The AHEI-2010 score was not significantly associated with cognitive performance. Higher loading on a plant polyunsaturated fatty acid (PUFA)/vitamin E factor was associated with better baseline global cognitive function and executive function (β = 0.22 (0.02, 0.42) and β = −7.85 (−13.20, −2.47)). A sugar/low protein factor was associated with poorer baseline cognitive function across multiple domains. Dietary patterns were not associated with cognitive decline over time. Adherence to a healthy diet with foods high in PUFA and vitamin E and a low sugar to protein ratio, as typified by a Mediterranean diet, may be beneficial for cognitive health in late life.

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Section: Discussionmentioning

confidence: 99%

Dietary Patterns and Cognitive Function among Older Community-Dwelling Adults

et al. 2018

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“…After reviewing 80 micronutrients on the effect of AD, a 2014 meta-analysis portrayed that vitamin E was displayed in lower plasma levels in patients with AD [ 30 ]. Four years later, another meta-analysis was done in 2018 and concluded that AD is associated with a low concentration of serum vitamin E [ 31 ].…”

Section: The Role Of Antioxidants In Alzheimer’s Disease Treatmentsmentioning

confidence: 99%

Alzheimer’s Disease, Inflammation, and the Role of Antioxidants

Sinyor

Mineo

Ochner

2020

ADR

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The World Health Organization refers to Alzheimer’s disease (AD) as a global health priority. As the average age of the world’s population is increasing, so too is the rate of AD. There are an estimated 47 million people globally who have been diagnosed with AD dementia, and researchers have yet to figure out the root cause. All misfolded aggregate proteins that are involved in neurodegenerative disorders (amyloid-β, Huntington’s tau, α -synuclein) induce oxidative stress. It is that oxidative stress that leads to inflammation and, in conjunction with amyloid protein and tau hyperphosphorylation, progresses to and exacerbates AD. The consumption of antioxidants and nutrients, specifically vitamin E, caffeine, and turmeric, may slow the progression of AD and can be found in a wide variety of dietary foods. This review explores the role of inflammation on AD, the antioxidants that can potentially combat it, and future directions of how the treatment of the disease can be better understood.

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“…In addition, vitamin E offers protection from the propagative damage of ROS by inhibiting the oxidative modi ication of lipoproteins [84,85]. Indeed, a study comprising 904 patients with AD and 1,153 healthy older controls con irmed that serum vitamin E levels were lower in the AD patients compared with the controls [86]. In this regard, an increased intake of quality dairy, fresh fruit, vegetables, ish, and whole grains, along with the reduced consumption of fried potatoes, sweets, and processed meat, may provide an ef icacious nutrient combination and offer protection against AD [84,87].…”

Section: Alzheimer's Disease and Nutrientsmentioning

confidence: 99%

Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species

Madireddy¹,

Madireddy²

2019

J Neurosci Neurol Disord

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Vitamin E Antioxidant, Neuroprotection Vitamin E is a scavenger of several ROS and serves to reduce their reactivity and toxicity. It offers protection from the propagative damage of ROS by inhibiting the oxidative modifi cation of lipoproteins AD [74-79,82-86] PD [175-177,79] ALS [193,217,218] Vitamin C Antioxidant, Neuroprotection Vitamin C is an excellent antioxidant, suitable in reducing ROS levels, lipid peroxidation, and oxidative stress. It is also useful in regenerating other antioxidants. AD [81,82,75,77,79] PD [166-168] ALS [213,214] Vitamin D Antioxidant Neuroprotection Vitamin D prevent oxidative stress, lower the production of free radicals, and reduce neurotoxicity through the enhancement of autophagy signaling pathways AD [74-78,30,16,80] PD [157-159,169-174] ALS [215,216] Vitamin A Antioxidan Vitamin A prevent the formation of Aβ plaques AD [16,30,74-78] Vitamin B Antioxidant Neuroprotection Vitamin B perform antioxidant and neuroprotective functions AD [88-90] PD [157-159,162-165] HD [105] Curcumin Antioxidant Anti-infl ammatory Neuroprotection Curcumin is a scavenger of free radicals and reduces mitochondrial disfunction. AD [100,101] Omega−3 fatty acids Antioxidant Anti-infl ammatory Omega-3 fatty acids reduce ROS formation acting as free radical scavengers.

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Do low‐serum vitamin E levels increase the risk of Alzheimer disease in older people? Evidence from a meta‐analysis of case‐control studies

Abstract: Alzheimer disease is associated with a low concentration of serum vitamin E in older people. However, necessary prospective cohort studies should be conducted to determine the risk of serum vitamin E for AD in the future.

Cited by 23 publications

References 33 publications

Dietary Patterns and Cognitive Function among Older Community-Dwelling Adults

Dietary Patterns and Cognitive Function among Older Community-Dwelling Adults

Alzheimer’s Disease, Inflammation, and the Role of Antioxidants

Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species

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