Do interleukin‐1 polymorphisms predict the development of jreiodontitis or the success of dental implants?

Abstract

Factors which increase the risk of severe adult periodontitis (AP) may also contribute to the success of dental implants. To determine which cytokines may be relevant, levels of interleukin-1alpha (IL-1alpha), interleukin-1beta (IL-1beta), interleukin-1 receptor antagonist (IL-1ra), interleukin-6 (IL-6) and interferon-gamma (IFN-gamma) mRNA were quantitated in gingival tissue from periodontitis patients and healthy controls. Periodontitis significantly increased levels of IL-1alpha, IL-1beta, IL-6 and IFN-gamma mRNA relative to healthy tissues. IL-1 was selected for further study, as it has inflammatory and bone resorbing properties. We examined IL-1A(-889) and IL-1B(+3953) alleles in Caucasian patients with AP and early-onset periodontitis (EOP), patients with dental implants and healthy individuals. The IL-1B(+3953) polymorphism was associated with AP. This was evident from an increased homozygosity for allele 2 in patients with AP and a decreased heterozygosity in advanced AP patients. IL-1A(-889) and a composite genotype [IL-1A(-889)2 plus IL-1B(+3953)2] showed no association with the incidence of periodontitis, disease onset or disease severity. IL-1A(-889), IL-1B(+3953) and the composite genotype also showed no association with failure of dental implants.

Interleukin-1 gene polymorphisms and periodontal status in a Spanish population

“…No significant difference was found between the groups with regard to the presence of IL-1 gene polymorphisms. This result is in line with the report by Rogers et al (18) whose findings indicated no difference among groups with chronic PD, early-onset periodontitis, and no PD in the presence of IL-1A (+4845) polymorphism or positive genotype. These authors did not detect any correlation between IL-1 polymorphisms and susceptibility to implant loss.…”

“…However, other authors found no such correlation (18)(19)(20), thus the issue remains controversial. The aim of the present study was to examine the association between IL-1β in GCF and PD activity and to investigate the presence of IL-1 gene polymorphisms and their possible relationship with the disease, in a Spanish population.…”

Association between IL-1α rs17561 and IL-1β rs1143634 polymorphisms and periodontitis: a meta-analysis

“…IL-1α is mainly produced by keratinocytes of the junctional or pocket epithelium, and is a mediator of local inflammation, regulating intracellular events (Dinarello, 2002). In the current study, the IL-1α rs17561 polymorphism showed a strong association with periodontitis (Rogers et al, 2002;Wagner et al, 2007;López et al, 2009). However, several other authors have been unable to demonstrate any such relationship (Anusaksathien et al, 2003;Sakellari et al, 2003;Brett et al, 2005;Kobayashi et al, 2007;Ferreira Jr. et al, 2008).…”

El polimorfismo de la IL-1 y su eventual asociación con la enfermedad periodontal crónica: Una revisión de la literatura (II)

“…Otro estudio realizado por McDevitt y col. (23) con no fumadores o ex fumadores con una historia de < 5 paquetes/año, investigaron la presencia de polimorfismos en otro conjunto de genes, IL-1α (+4845) e IL-1β (+3954 s Relación del genotipo positivo con la prevalencia de la enfermedad periodontal. Rogers y col. (27) no encontraron diferencias significativas en cuanto al polimorfismo en el gen IL-1A en la posición +4845 o a ser genotipo positivo entre un grupo con enfermedad peridontal crónica, otro con periodontitis rápi-damente progresiva y un tercer grupo de pacientes sanos. Por otro lado, también observaron que la posesión de polimorfismos en los genes de la IL-1 no aumentaba la susceptibilidad en la pérdida de implantes.…”