Do insulin-like growth factors play a role in final follicular maturation: Superovulation as a test model

Leemput, E.E. van de; Hem, Annelise; Sprang, E.P.M.; Vos, P.L.A.M.; Dieleman, S.J.

doi:10.1016/s0093-691x(97)82331-x

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“…Same findings were reported in human ovaries (Giudice 2001). IGF‐I levels in follicular fluids increase with follicle size, and stimulatory effects on granulosa cells and oocytes have been observed (Van de Leemput et al. 1997).…”

Section: Discussionmentioning

confidence: 99%

Characterization of Immunoreactive IGF‐I Pattern During the Peri‐ovulatory Period of the Oestrous Cycle of Thoroughbred Mares and Its Relation to Other Hormones

Derar

Taya

Watanabe

et al. 2011

Reprod Domestic Animals

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The aim of this study was to characterize ir-IGF-I pattern and its relation to other hormones during the oestrous cycle in mares. Nine non-pregnant non-lactating pluriparous thoroughbred mares were used. The studied mares were examined ultrasonically and bled daily to follow the ovarian changes and the hormonal milieu for a complete Interovulatory interval (IOI). Two (minor and major) follicular waves were characterized per IOI in thoroughbred mares. The largest follicle of the first follicular wave (DF1) was firstly detected at D - 1.75 ± 0.47 with a growth rate of 2.78 ± 0.14mm/day and maximum diameter of 22.45 ± 0.75mm on day 6.65 ± 0.82. The largest follicle of the second follicular wave (DF2) had a growth rate of 2.15 ± 0.29 mm/day, reached a maximum diameter of 42.70 ± 2.63 mm on D 19.25 ± 0.43. Ir-IGF-I increased significantly prior to ovulation and had a similar pattern to oestrogen (r = 0.84, p < 0.05), suggesting that the ovarian follicles are the main source of circulating ir-IGF-I during the oestrous cycle of mares and that ir-IGF-I may be a crucial factor in follicular differentiation and maturation. In conclusion, this study demonstrated that ir-IGF-I is secreted during the oestrous phase of the cycle concomitant with the development of the future ovulatory dominant follicle, and it may act in synergy with other hormones for the selection and differentiation of the dominant follicle.

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Section: Discussionmentioning

confidence: 99%