Do Histopathology and Clinical Outcomes of Breast Atypia Vary by Race/Ethnicity?

Sergesketter, Amanda R.; Thomas, Samantha M.; Castellar, Edgardo R. Parrilla; Fayanju, Oluwadamilola M.; Menendez, Carolyn S.; Hwang, E. Shelley; Plichta, Jennifer K.

doi:10.1016/j.jss.2020.05.066

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“…The study cohort included almost exclusively non-Hispanic White patients, thus not significantly contributing to our understanding of how race and ethnicity may be associated with BBD and subsequent breast cancer development. 3,4 Furthermore, the study lacks data regarding the interobserver reproducibility of certain benign diagnoses. The discrepancy among pathologists' interpretation of atypia has been well documented, with discordance rates over 50% in select studies.…”

Section: Invited Commentarymentioning

confidence: 99%

“…However, the generalizability of the data should be considered. The study cohort included almost exclusively non-Hispanic White patients, thus not significantly contributing to our understanding of how race and ethnicity may be associated with BBD and subsequent breast cancer development . Furthermore, the study lacks data regarding the interobserver reproducibility of certain benign diagnoses.…”

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confidence: 99%

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