Do Histopathological Features and Microcalcification Affect the Elasticity of Breast Cancer?

Durhan, Gamze; Öztekin, Pelin Seher; Ünverdǐ, Hatǐce; Değirmenci, Tülin; Durhan, Abdullah; Karakaya, Jale; Koşar, Pınar Nercis; Köseoğlu, Enver Necip; Hücümenoğlu, Sema

doi:10.7863/ultra.16.06064

Cited by 9 publications

(8 citation statements)

References 36 publications

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“…The major contribution of the present study lies in the prognostic value of elastography. Breast cancer is one of the most commonly diagnosed cancers in women worldwide, and various examinations have demonstrated promising performance for the detection, diagnosis, and prognostic evaluation of breast cancer [26]. Considering that personalized and targeted therapeutic approaches are largely dependent on accurate tumor characterization, both in terms of histological composition and biological aggressiveness, a non-invasive method capable of providing all the prognostic features is superior other techniques.…”

Section: Discussionmentioning

confidence: 99%

Quantitative and Qualitative Evaluation of Breast Cancer Prognosis: A Sonographic Elastography Study

You

Song

et al. 2019

Med Sci Monit

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BackgroundBreast cancer is one of the most commonly diagnosed cancers in women worldwide, and sonographic elastography has previously demonstrated good performance in detecting breast malignancies. However, the exact relationship between elastographic measures and clinical prognostic factors is still not well understood. Thus, the aim of this study was to evaluate any associations between major clinical prognostic factors and strain elastography and to validate the diagnostic value of elastography in breast cancer.Material/MethodsA total of 373 subjects with breast masses, of which 196 were benign and 177 were malignant, were included in the study. All subjects underwent routine ultrasound examination and strain elastography before biopsy. The elastographic measures – strain ratio (SR) for qualitative measures and Tsukuba score (TS) for quantitative measures – were obtained and compared with prognostic factors, including nuclear grade, lymph node status, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (HER-2). The SR demonstrated the best diagnostic performance in differentiation between malignant and benign lesions.ResultsWith the best cut-off value at 2.42, the SR achieved a sensitivity of 96.0% and specificity of 98.5%. Moreover, higher SRs and TSs were associated with breast lesions with a high nuclear grade and lymph node metastasis and with being ER-negative, PR-negative, and HER-2 negative.ConclusionsElastography is a useful imaging technique in differentiating benign breast masses from malignant ones. The strong relationship between prognostic factors and elastographic measures also demonstrated its excellent performance in predicting the prognosis of breast malignancies.

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Section: Discussionmentioning

confidence: 99%

Quantitative and Qualitative Evaluation of Breast Cancer Prognosis: A Sonographic Elastography Study

You

Song

et al. 2019

Med Sci Monit

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“…Most of the microcalcifications are located in the lumen of DCIS and can also be found in IDC. It has been reported that microcalcifications in breast cancer were closely related to recurrence of DCIS and the invasion or metastasis of IDC 24…”

Section: Discussionmentioning

confidence: 99%

<p>Microcalcification and BMP-2 in breast cancer: correlation with clinicopathological features and outcomes</p>

Zhang¹,

Hao²,

Wu³

et al. 2019

OTT

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BackgroundMicrocalcification is a very important diagnostic information in breast cancer. The purpose of this study was to determine the relationship of clinicopathological features and prognosis of breast cancer with microcalcification and to detect biomarkers related to the possible mechanisms of microcalcifications.Patients and methodsAll 529 subjects with microcalcifications were selected from patients who had been examined using breast mammography. The control group did not have detectable microcalcifications, and was matched in a ratio of 1:3. The clinicopathological factors, progression-free survival (PFS), and overall survival were evaluated by SPSS.ResultsThere was a significant difference in tumor size between the two groups, with larger tumors in the calcification group than the control group, and the proportion of patients in the calcification group with tumors of >5 cm was 20.4% vs 17.2% in the control group (P=0.041). The proportion of patients with lymph node metastasis in the calcification group was higher than that of the control group (35% vs 27.9%, P=0.027). The recurrence rate in ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) patients with microcalcification was higher than that in the control group (P=0.035 and 0.044). BMP-2 expression was higher in breast cancer tissues, especially in breast cancer tissues with microcalcifications. The recurrence rate in the BMP-2(+) group was higher than that in the BMP-2(−) group both in DCIS and IDC (P=0.044 and 0.049). Microcalcifications and the positive expression of BMP-2 were independent factors affecting the PFS of the breast cancer patients.ConclusionThrough the analysis of this study, it was found that the prognosis of the patients with microcalcification was relatively poor. BMP-2 was highly expressed in the breast cancer with microcalcification and was associated with poor prognosis.

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“…Our previous study and several other studies have demonstrated that FF is associated with poor prognostic markers for breast cancer [14][15][16][17]. Some studies have reported an association between US elastography results and clinicopathological factors in breast cancer [7][8][9][10]. However, there have been no studies on the relationship between FF and US elastography in breast cancer.…”

Section: Introductionmentioning

confidence: 85%

“…Malignant breast tumors show increased stiffness on US elastography compared to benign lesions, but several studies have shown different elastographic findings in invasive breast cancer [7][8][9]. Several factors have been suggested in previous studies regarding the cause of the difference in elasticity in breast cancer, but this remains unclear [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Clinical Significance of Ultrasound Elastography and Fibrotic Focus and Their Association in Breast Cancer

Lee

Jeong

2022

JCM

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(1) Background: Ultrasound (US) elastography is an imaging technology that reveals tissue stiffness. This study aimed to investigate whether fibrotic focus (FF) affects elastographic findings in breast cancer, and to evaluate the clinical significance of US elastography and FF in breast cancer. (2) Methods: In this study, 151 patients with breast cancer who underwent surgery were included. Strain elastography was performed and an elasticity scoring system was used to assess the findings. The elasticity scores were classified as negative, equivocal, or positive. FF was evaluated in the surgical specimens. Medical records were reviewed for all patients. (3) Results: Elastographic findings were equivocal in 30 patients (19.9%) and positive in 121 patients (80.1%). FF was present in 68 patients (46.9%). There was no correlation between elastographic findings and FF. Older age, larger tumor size, lymph node metastasis, and higher tumor stage were associated with positive elastographic results. FF showed a positive correlation with age, postmenopausal status, tumor size, lymphovascular invasion, lymph node metastasis, tumor stage, and intratumoral and peritumoral inflammation. (4) Conclusions: Our study showed that positive elastographic results and FF were associated with poor prognostic factors for breast cancer. FF did not affect the elastographic findings of this study.

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Do Histopathological Features and Microcalcification Affect the Elasticity of Breast Cancer?

Abstract: Grade 3 invasive ductal carcinomas are different from other grades with lower SR values. The presence of microcalcifications and molecular subtypes do not affect elasticity like a high histological grade does.

Cited by 9 publications

References 36 publications

Quantitative and Qualitative Evaluation of Breast Cancer Prognosis: A Sonographic Elastography Study

Quantitative and Qualitative Evaluation of Breast Cancer Prognosis: A Sonographic Elastography Study

<p>Microcalcification and BMP-2 in breast cancer: correlation with clinicopathological features and outcomes</p>

Clinical Significance of Ultrasound Elastography and Fibrotic Focus and Their Association in Breast Cancer

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