Do highly oncogenic group A human adenoviruses cause human cancer? Analysis of human tumors for adenovirus 12 transforming DNA sequences.

Mackey, Jesse K.; Rigden, Patricia; Green, Maurice

doi:10.1073/pnas.73.12.4657

Cited by 33 publications

(10 citation statements)

References 22 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After the discovery that human Ads could induce tumors in newborn rodents (53), the possibility that these viruses may induce human cancers stimulated a search for human Ad sequences in human tumors. The most extensive and careful of these studies, by Green and colleagues (54–58) and Mak et al (59), were uniformly negative. Although detection of Ad‐related RNA sequences in human neurogenic tumors by in situ hybridization has been reported (60), this finding has not been confirmed using more sensitive and reliable technologies.…”

Section: Discussionmentioning

confidence: 95%

Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells

et al. 2002

View full text Add to dashboard Cite

The 293 cell line was derived by transformation of primary cultures of human embryonic kidney (HEK) cells with sheared adenovirus (Ad)5 DNA. A combination of immunostaining, immunoblot, and microarray analysis showed that 293 cells express the neurofilament (NF) subunits NF-L, NF-M, NF-H, and a-internexin as well as many other proteins typically found in neurons. Three other independently derived HEK lines, two transformed by Ad5 and one by Ad12, also expressed NFs, as did one human embryonic retinal cell line transformed with Ad5. Two rodent kidney lines transformed with Ad12 were also found to express NF proteins, although several rodent kidney cell lines transformed by Ad5 DNA and three HEK cell lines transformed by the SV40 early region did not express NFs. These results suggest that human Ads preferentially transform human neuronal lineage cells. We also demonstrate that the widely used HEK293 cells have an unexpected relationship to neurons, a finding that may require reinterpretation of many previous studies in which it was assumed that HEK293 cells resembled more typical kidney epithelial cells.

show abstract

Section: Discussionmentioning

confidence: 95%

Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Although adenoviruses are not known to be associated with tumorigenesis in humans, some human adenovirus serotypes can directly induce tumours in rats or hamsters, and all serotypes tested can transform cultured rodent cells [128]. Two viral genes E1A and E1B were shown to be both necessary and sufficient for transformation [129].…”

Section: Small Dna Virusesmentioning

confidence: 99%

Human tumor suppressor p53 and DNA viruses

Collot-Teixeira

Bass

Denis

et al. 2004

Reviews in Medical Virology

View full text Add to dashboard Cite

Human tumor suppressor protein p53 plays a major role in the cell cycle, orchestrating a number of important genes involved in cell-cycle control and apoptosis, and seems to be one of the most important molecules protecting cells from malignant transformation. Mutations in the p53 gene are observed in about 50% of primary tumors, inducing defective p53 protein no longer capable of binding DNA and of activating transcription. Certain DNA viruses are thought to act in a similar way and may also contribute to the progression of invasive cancer in infected tissue. One of the most effective strategies employed by these viruses is the inhibition of p53 protein by interaction with viral oncoproteins, implying a direct but also an indirect role of these viruses in the impairment of p53 structure and function. This article provides a summary of current knowledge concerning p53 tumor suppressor protein and reviews the different mechanisms adopted by different DNA viruses in undermining p53 function.

show abstract

“…Early studies indicated that these nonenveloped, double-stranded DNA viruses have oncogenic potential in rodent cells (Trentin et al, 1962). However the initial excitement in this topic was later dampened by the discovery that the majority of primary human tumors lack HAdV DNA thus reducing the likelihood of the etiology of adenovirus in human cancers (Mackey et al, 1976). Nonetheless, HAdV has served as a particularly useful model system for uncovering fundamental aspects of molecular and cell biology including RNA splicing (Berget et al,1977; Chow et al,1977) and the regulation of the cell cycle (Chinnadurai, 1983; Yang et al, 1996).…”

Section: Adenovirus: a Brief Historical Perspectivementioning

confidence: 99%

Insights into adenovirus host cell interactions from structural studies

et al. 2009

View full text Add to dashboard Cite

Human adenoviruses cause a significant number of acute respiratory, enteric and ocular infections, however they have also served as useful model systems for uncovering fundamental aspects of cell and molecular biology. In addition, replication-defective forms of adenovirus are being used in gene transfer and vaccine clinical trials. Over the past decade, steady advances in structural biology techniques have helped reveal important insights into the earliest events in the adenovirus life cycle as well as virus interactions with components of the host immune system. This review highlights the continuing use of structure-based approaches to uncover the molecular features of adenovirus—host interactions.

show abstract

Do highly oncogenic group A human adenoviruses cause human cancer? Analysis of human tumors for adenovirus 12 transforming DNA sequences.

Abstract: ABSTRACT.Adenovirus 12 (Adl2 ) (Huie) (

Cited by 33 publications

References 22 publications

Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells

Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells

Human tumor suppressor p53 and DNA viruses

Insights into adenovirus host cell interactions from structural studies

Contact Info

Product

Resources

About