Do heart transplant recipients need annual coronary angiography?

Sechtem, Udo

doi:10.1053/euhj.2001.2660

Cited by 8 publications

(5 citation statements)

References 12 publications

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“…A recent adult study questioned the utility of routine angiographic surveillance to detect TCAD. 23 However, Smart et al 24 demonstrated the insensitivity of non-invasive tests to detect TCAD.…”

Section: Discussionmentioning

confidence: 98%

The Impact and Outcome of Transplant Coronary Artery Disease in a Pediatric Population: A 9-Year Multi-institutional Study

Pahl

Naftel

Kuhn

et al. 2005

The Journal of Heart and Lung Transplantation

146

120

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Section: Discussionmentioning

confidence: 98%

The Impact and Outcome of Transplant Coronary Artery Disease in a Pediatric Population: A 9-Year Multi-institutional Study

Pahl

Naftel

Kuhn

et al. 2005

The Journal of Heart and Lung Transplantation

146

120

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“…However, CA is an invasive technique and complications, especially at the vascular site, have been reported, 10 leading to much debate regarding the need for assessment as often as yearly. 9,24,25 Global improvements have been made in the safety of invasive CA, however. In our experience, 85% had CA by radial approach.…”

Section: Screening Of Cavmentioning

confidence: 99%

Multislice computed tomography to rule out coronary allograft vasculopathy in heart transplant patients

Barthélémy

Tolédano

Varnous

et al. 2012

The Journal of Heart and Lung Transplantation

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“…Thus, despite its low sensitivity and intrinsic limitations, coronary angiography remains the most widely used technique for CAV screening, due to its high specificity and its prognostic value. Nevertheless, the policy for CAV surveillance is not uniform among heart transplant programs, and the value of repeated annual angiography has been questioned (13,14). Taking into account the risk for donor-transmitted disease and the average time of angiographic appearance of CAV, some authors suggest that a coronary angiography should be performed early post-transplant and then after three to five years (9,10).…”

Section: Diagnosismentioning

confidence: 99%

Cardiac Allograft Vasculopathy: Differences in De Novo and Maintenance Heart Transplant Recipients

et al. 2006

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Advances in immunosuppressive therapies in the past decade have improved short-term survival following heart transplantation, but cardiac allograft vasculopathy (CAV) has remained a major cause of mortality and morbidity in the long-term. CAV is often underdiagnosed by coronary angiography; intravascular ultrasound (IVUS) is currently the gold standard for diagnosis of CAV, with an increase in maximal intimal thickness of Ն0.5 mm from baseline to one year post-transplant representing a risk factor for the incidence of cardiac events during follow-up. Non-invasive tests such as stress echocardiography or scintigraphy evaluate the impact of CAV on myocardial function and/or perfusion. They provide useful prognostic information and may serve as screening tests for selecting patients who need invasive evaluation. The need for effective strategies to prevent CAV, and control its progression once established, is of utmost importance to improve long-term survival and quality of life after heart transplantation. Proliferation signal inhibitors (PSIs) have been demonstrated to slow the development of CAV and to reduce the rate of cardiac events in de novo heart transplant recipients. In maintenance patients, palliation of the disease with percutaneous revascularization is being attempted with increasing frequency, with satisfactory short-term success and possible but unproven long-term benefit. A pilot, single-center, randomized study with sirolimus versus standard care suggests that PSIs may also be effective in limiting the progression of established CAV, validating the need for this hypothesis to be explored in larger trials.

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Do heart transplant recipients need annual coronary angiography?

Cited by 8 publications

References 12 publications

The Impact and Outcome of Transplant Coronary Artery Disease in a Pediatric Population: A 9-Year Multi-institutional Study

The Impact and Outcome of Transplant Coronary Artery Disease in a Pediatric Population: A 9-Year Multi-institutional Study

Multislice computed tomography to rule out coronary allograft vasculopathy in heart transplant patients

Cardiac Allograft Vasculopathy: Differences in De Novo and Maintenance Heart Transplant Recipients

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