2003
DOI: 10.1016/s1569-9048(03)00042-9
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Do genes on rat chromosomes 9, 13, 16, 18, and 20 contribute to regulation of breathing?

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Cited by 16 publications
(22 citation statements)
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“…BN is the only strain in our study previously evaluated by others investigating strain-genetic effects on ventilatory control (13,20,37,38 no strain effects on resting minute ventilation. However, BN and Zucker rats utilized a more rapid, shallow breathing pattern relative to the other strains.…”
Section: Discussionmentioning
confidence: 94%
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“…BN is the only strain in our study previously evaluated by others investigating strain-genetic effects on ventilatory control (13,20,37,38 no strain effects on resting minute ventilation. However, BN and Zucker rats utilized a more rapid, shallow breathing pattern relative to the other strains.…”
Section: Discussionmentioning
confidence: 94%
“…Hodges et al (20) reported that, although BN rats responded to hypoxia with less change in minute ventilation than other strains, hypoxic arterial PCO 2 (Pa CO 2 ; and therefore magnitude of hyperventilation) was similar to other strains. Although not directly measured, these data suggest BN rats experience greater hypoxia-induced hypometabolism, an effect that may be associated with genetic differences on chromosomes 9 and 18 (13). Thus it may be that the unique ventilatory response of BN rats reflects differences in the genetic determinants of metabolic regulation vs. ventilatory control per se.…”
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confidence: 80%
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