Do Fresh Osteochondral Allografts Successfully Treat Femoral Condyle Lesions?

Levy, Yadin D.; Görtz, Simon; Pulido, Pamela A.; McCauley, Julie C.; Bugbee, William D.

doi:10.1007/s11999-012-2556-4

Cited by 222 publications

(248 citation statements)

References 34 publications

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“…10 Other studies have highlighted that patients older than 30 years at the time of surgery and with 2 or more prior surgeries were more likely to have allograft failure. 11 These studies demonstrate that patient selection and injury timing are crucial for both patient selection and the survival of large osteochondral allograft transplants.…”

Section: Discussionmentioning

confidence: 89%

Tibial Allograft Transfer for Medial Tibial Plateau Resurfacing

Godin

Frangiamore

Chahla

et al. 2017

Arthroscopy Techniques

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A large cartilage lesion of the tibial plateau with a deficient meniscus in a young patient is a challenging pathology for the orthopaedic surgeon due to the limited options available. While hemiarthroplasty procedures can be an option, the risk of revision in a young patient is high, and therefore a reconstructive procedure is advocated. The purpose of this Technical Note is to describe our technique for tibial plateau resurfacing, including the preparation and implantation of a medial tibial plateau and medial meniscal allograft, in a patient with a post-traumatic KD-4 knee dislocation with a medial tibial plateau rim fracture, medial meniscus deficiency, and medial tibiofemoral joint subluxation.

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Section: Discussionmentioning

confidence: 89%

Tibial Allograft Transfer for Medial Tibial Plateau Resurfacing

Godin

Frangiamore

Chahla

et al. 2017

Arthroscopy Techniques

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“…6,[8][9][10] A retrospective study of 46 patients by Gracitelli et al 8 reported an 87.4% 10-year graft survivorship. A prospective study of 25 patients by McCulloch et al 9 reported graft incorporation into host bone in 22 of 25 (88%) patients.…”

Section: Discussionmentioning

confidence: 99%

“…LaPrade et al 6 followed 23 patients over 3 years and showed improvement in Cincinnati scores from 49.2 to 69.0 (P < .02), International Knee Documentation Committee score improvement from 52.0 to 68.3 (P < .03), and evidence of graft healing in 22 of 23 patients (96%). Recently, Levy et al 10 reported a retrospective case series of 122 patients (129 knees) between 1983 and 2011, with a survivorship of 82% at 10 years, 74% at 15 years, and 66% at 20 years. However, the applicability of this study is limited as a result of their allografts being transplanted within 7 days postmortem.…”

Section: Discussionmentioning

confidence: 99%

Fresh Osteochondral Allograft Transplantation for Treatment of Articular Cartilage Defects of the Knee

Dean

Chahla

Cruz

et al. 2016

Arthroscopy Techniques

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Articular cartilage damage of the knee can cause severe morbidity. Owing to its avascular nature, articular cartilage has limited potential for self-healing and increased propensity to progress to osteoarthritis. Treatment of large, full-thickness cartilage defects is still a challenge for orthopaedic surgeons but has recently achieved high success rates with the use of osteochondral allografts. This article details our technique of osteochondral allograft transplantation for the treatment of articular cartilage defects of the knee.

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“…Instead of using exogenous biomaterials, scaffold-free • Short-term clinical results not sustained through long-term followup [16][17][18]24,27,95] Osteochondral autograft (mosaicplasty)…”

Section: Drawbacks Of Current Tissue Engineering Approaches For Osteomentioning

confidence: 99%

Bioprinting of osteochondral tissues: A perspective on current gaps and future trends

Datta

Dhawan

et al. 2024

IJB

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Abstract:Osteochondral tissue regeneration has remained a critical challenge in orthopaedic surgery, especially due to complications of arthritic degeneration arising out of mechanical dislocations of joints. The common gold standard of autografting has several limitations in presenting tissue engineering strategies to solve the unmet clinical need. However, due to the complexity of joint anatomy, and tissue heterogeneity at the interface, the conventional tissue engineering strategies have certain limitations. The advent of bioprinting has now provided new opportunities for osteochondral tissue engineering. Bioprinting can uniquely mimic the heterogeneous cellular composition and anisotropic extra-cellular matrix (ECM) organization, while allowing for targeted gene delivery to achieve heterotypic differentiation. In this perspective, we discuss the current advances made towards bioprinting of composite osteochondral tissues and present an account of challenges-in terms of tissue integration, long-term survival, and mechanical strength at the time of implantation-required to be addressed for effective clinical translation of bioprinted tissues. Finally, we highlight some of the future trends related to osteochondral bioprinting with the hope of in-clinical translation. Keywords: bioprinting; osteochondral injuries; zonal anisotropy; bioink; tissue engineering

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Do Fresh Osteochondral Allografts Successfully Treat Femoral Condyle Lesions?

Abstract: Followup of femoral condyle osteochondral allografting demonstrated durable improvement in pain and function, with graft survivorship of 82% at 10 years.

Cited by 222 publications

References 34 publications

Tibial Allograft Transfer for Medial Tibial Plateau Resurfacing

Tibial Allograft Transfer for Medial Tibial Plateau Resurfacing

Fresh Osteochondral Allograft Transplantation for Treatment of Articular Cartilage Defects of the Knee

Bioprinting of osteochondral tissues: A perspective on current gaps and future trends

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