Do foodborne polyethylene microparticles affect the health of rainbow trout (Oncorhynchus mykiss)?

Hodkovicová, Nikola; Hollerová, Aneta; Čaloudová, Hana; Blahová, Jana; Franc, Aleš; Garajová, Michaela; Lenz, Jiří; Tichý, František; Faldyna, Martin; Kulich, Pavel; Mareš, Jan; Machát, Radek; Enevova, Vladimira; Svobodová, Zdeňka

doi:10.1016/j.scitotenv.2021.148490

Cited by 35 publications

(10 citation statements)

References 92 publications

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“…Therefore, more research in animals is needed to identify biomarkers of MPs toxicity, such as the disruption in immunity indices (acid phosphatase and alkaline phosphatase activity) and oxidative stress indices (total antioxidant capacity and malondialdehyde content) previously observed, for example, in juvenile and adult sea cucumbers [65,66]. Polyethylene microparticles have been shown to have an effect on haematological and biochemical indices, the antioxidant defence system, and expression of selected genes associated with the immune profile [67].…”

Section: Resultsmentioning

confidence: 99%

“…Risk characterization is the final step of the risk assessment, in which the likelihood that a particular substance (MPs in this case) will cause harm is calculated in the light of the nature of the hazard and the extent to which people are exposed to it [99]. Some authors affirm that even though fish have been observed to be able to cope with the PE toxic effects, their consumption could pose serious health risks to humans [67]. However, as there are insufficient reference values to evaluate the MPs dietary intake, the MPs risk characterization for dietary MPs is not possible at present.…”

Section: Resultsmentioning

confidence: 99%

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Microplastics as Emerging Food Contaminants: A Challenge for Food Safety

Rubio

Alejandro-Vega

Paz-Montelongo

et al. 2022

IJERPH

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Microplastics (MPs) have been identified as emerging environmental pollutants classified as primary or secondary based on their source. Composition, shape, size, and colour, among other characteristics, are associated with their capacity to access the food chain and their risks. While the environmental impact of MPs has received much attention, the risks for humans derived from their dietary exposure have not been yet assessed. Several institutions and researchers support that the current knowledge does not supply solid data to complete a solid risk characterization of dietary MPs. The aim of this paper is to review the current knowledge about MPs in foods and to discuss the challenges and gaps for a risk analysis. The presence of MPs in food and beverages has been worldwide observed, but most authors considered the current data to be not only insufficient but of questionable quality mainly because of the outstanding lack of consensus about a standardized quantifying method and a unified nomenclature. Drinking water, crustaceans/molluscs, fish, and salt have been identified as relevant dietary sources of MPs for humans by most published studies. The hazard characterization presents several gaps concerning the knowledge of the toxicokinetic, toxicodynamic, and toxicity of MPs in humans that impede the estimation of food safety standards based on risk. This review provides a tentative exposure assessment based on the levels of MPs published for drinking water, crustaceans and molluscs, fish, and salt and using the mean European dietary consumption estimates. The intake of 2 L/day of water, 70.68 g/day of crustaceans/molluscs, 70.68 g/day of fish, and 9.4 g/day of salt would generate a maximum exposure to 33,626, 212.04, 409.94 and 6.40 particles of MPs/day, respectively. The inexistence of reference values to evaluate the MPs dietary intake prevents the dietary MPs risk characterization and therefore the management of this risk. Scientists and Food Safety Authorities face several challenges but also opportunities associated to the occurrence of MPs in foods. More research on the MPs characterization and exposure is needed bearing in mind that any future risk assessment report should involve a total diet perspective.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Microplastics as Emerging Food Contaminants: A Challenge for Food Safety

Rubio

Alejandro-Vega

Paz-Montelongo

et al. 2022

IJERPH

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“…Studies using EM in fish displayed alterations in the chloride cell, goblet cell, and lamellae of gill and the liver showed necrosis, vacuolation, and erythrocyte infiltration upon exposure to various toxicants (Jindal & Kaur, 2014, 2015; Johal & Sharma, 2007; Vajargah et al, 2021). Hodkovicova et al (2021) revealed the presence of polyethylene microplastic in the gills and intestine of the fish. Occurrence of lamellar degeneration along with affected goblet and chloride cells in gills supported the physiological relevance of altered respiration rate and gaseous exchangeability.…”

Section: Em In Toxicity Assessmentmentioning

confidence: 99%

Imperative role of electron microscopy in toxicity assessment: A review

Grover

Sinha

Faggio

2021

Microscopy Res & Technique

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Electron microscope (EM) was developed in 1931 and since then microscopical examination of both the biological and non‐biological samples has been revolutionized. Modifications in electron microscopy techniques, such as scanning EM and transmission EM, have widened their applicability in the various sectors such as understanding of drug toxicity, development of mechanism, criminal site investigation, and characterization of the nano‐molecule. The present review summarizes its role in important aspects such as toxicity assessment and disease diagnosis in special reference to SARS‐COV2. In the biological system, EM studies have elucidated the impact of toxicants at the ultra‐structural level in various tissue in conformity to physiological alterations. Thus, EM can be concluded as an important tool in toxicity assessment and disease prognosis.

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“…is depressed after exposure to high concentrations of MP (Hamed et al, 2020). Persistent anemia in juveniles of this species is MP concentration and exposure time-dependent, increasing mortality risks (Hamed et al, 2019); the same happens with innate immunity depression and liver damage in Oncorhynchus mykiss (Hodkovicova et al, 2021). At realistic exposure levels -similar to those that can occur in many coasts, polystyrene particles induce DNA degradation in the commercial mussel Mytilus J o u r n a l P r e -p r o o f galloprovincialis (Masiá et al, 2021b).…”

mentioning

confidence: 94%