Do extracts of oral soybean augment the trophic effect of estrogen on the rat uterus?

Francisco, A.M.C.; Carbonel, Adriana Aparecida Ferraz; Simões, Ricardo Santos; Soares, José Maria; Baracat, Edmund Chada; Haidar, Mauro Abi

doi:10.3109/13697137.2012.679168

Cited by 12 publications

(6 citation statements)

References 34 publications

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“…consistent with both estrogenic and anti-estrogenic action which is in agreement with the general knowledge on phytoestrogens (particularly isoflavones) known to exert a dose-dependent biphasic profile on several estrogenic endpoints. Administration of the low dose of E. excelsa extract to ovariectomised rats induced uterine growth, an effect that corroborates published data on most phytoestrogens either as single pure compounds (Diel et al 2004a) or mixtures (Francisco et al 2013). The impact of this estrogen-like effect on hormone-dependent cancer outcomes is controversially discussed and although some studies reported an inverse association between phytoestrogen consumption and endometrial cancer risk (Bandera et al, 2009), caution should be taken when considering the intake of the extract by postmenopausal women.…”

Section: Discussionsupporting

confidence: 82%

Erythrina excelsaexhibits estrogenic effectsin vivoandin vitroand is cytotoxic on breast and colon cancer cell lines

Ngueu

Tchoumtchoua

Njamen

et al. 2015

Pharmaceutical Biology

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Section: Discussionsupporting

confidence: 82%

Erythrina excelsaexhibits estrogenic effectsin vivoandin vitroand is cytotoxic on breast and colon cancer cell lines

Ngueu

Tchoumtchoua

Njamen

et al. 2015

Pharmaceutical Biology

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“…Comparable results were obtained with methanolic extracts of Millettia conraui bark, leaves of Bridelia ferruginea [32], and also onion extract [36]. More pronounced uterotrophic effects, mainly resulting in proliferation of endometrial and myometrial cells, were obtained by treating ovariectomized female rats with different soy extracts [27,37]. This uterotrophic effect of estrogens or compounds with estrogen-like activity has been described as biphasic.…”

Section: Discussionmentioning

confidence: 96%

Fenugreek seeds estrogenic activity in ovariectomized female rats

Hind

Elbachir

Amrani

et al. 2019

Current Issues in Pharmacy and Medical Sciences

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The estrogenic activities of fenugreek seeds (Trigonella foenum-graecum L.), widely used in traditional pharmacopoeia, are reflected in the uterus of ovariectomized female rats, with a slight increase in dry and wet weight, a thickening of the stroma and the uterine epithelium and the development of the endometrial glands. In the vagina, the estrogenic action is shown through an increase in the epidermal cell number and a tendency to keratinization, leading to vaginal opening. Furthermore, this estrogenic potential of fenugreek seeds is confirmed by the over-expression of progesterone receptors in the uterine tissues supporting possible interactions between phytoestrogens and estrogen receptors. Therefore, Fenugreek seeds may be capable of promoting the development of reproductive tissues of immature ovariectomized rats, and its estrogenic activity may take its action by holding phystoestrogens that interact with estrogen binding sites and activate the same estradiol-mediated cell signaling pathways. Thus, our results give added scientific support to the popular use of Fenugreek seeds as an alternative for several health problems such as fertility and menopause related disorders.

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“…The majority of the studies observed either no effects or beneficial effects of supplementation with isoflavones on the target organs. Adverse effects were also reported concerning the uterus as the target organ and comprised of: -Increased uterine weights and uterine morphometry showing trophic effects for rats administered 120 mg soy extract/kg [bw]/ day / 42.6 mg isoflavones /kg [bw] /day for 3 weeks (Francisco 2013). -Signs of endometrial proliferation and endometrial squamous metaplasia in rats administered doses of 125 and 250 µg genistein/g bw/day for 30 days ) -Increased uterine weight of rats administered a high-dose of 200 mg equol/kg diet (converted to ~18 mg/kg bw/day by the authors of this report using the EFSA default values for acute/subacute/chronic studies in female mice/rats (EFSA Scientific Committee, 2012)) for 8 weeks (Legette 2009).…”

Section: Results Objective 2: Animal Studiesmentioning

confidence: 99%

Preparatory work to support the risk assessment for peri‐ and postmenopausal women taking food supplements containing isolated isoflavones

Tijhuis

Doets

Velpen

et al. 2015

EFSA Supporting Publications

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Suggested citation: M Tijhuis, E Doets, V van der Velpen and M Vonk Noordegraaf-Schouten, 2015; Preparatory work to support the risk assessment for peri-and postmenopausal women taking food supplements containing isolated isoflavones. ABSTRACTThe aim of this review was to identify the scientific data from January 2009 till December 2013 on effects of isolated isoflavones from food supplements on reproductive organs (breast, uterus) and thyroid of menopausal women. A search in PubMed, Web of Science, CAB Abstracts and Embase (search date: February 7 th 2014), resulted in 2,497 unique hits. Based on title and abstract, 177 articles were eligible for full text selection. Of these, 95 were human studies (objective 1), 68 were animal studies (objective 2) and 14 contained data on both. Hand search yielded no additional articles. After full text screening, for objective 1, 14 articles met our inclusion criteria for data extraction; for objective 2, 17 met our inclusion criteria for data-extraction and 7 were included for mapping purposes; from articles with data for objective 1 and 2 combined, all 14 were excluded. All included studies were intervention studies. A grey literature search resulted in 1 relevant risk assessment published by a national body. Uterus was the most studied target organ for both objectives; the most prevalent outcomes were endometrial thickness for objective 1 and uterine weight for objective 2. Under objective 2, no studies evaluating thyroid were identified. Studies under objective 1 did not report adverse effects related to isoflavone supplementation, studies under 2 were less consistent. Many methodological issues exist, such as the scarcity of long-term human data and studies aimed at detecting adverse effects; and issues of metabolic differences between species and dose translation from animals to humans.

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Do extracts of oral soybean augment the trophic effect of estrogen on the rat uterus?

Abstract: Our results indicate that soy extract has a trophic effect on rat uterine structures. Treatment of ovariectomized rats with a concentrated soy extract in combination with conjugated estrogens had no addictive effect on the uterine response.

Cited by 12 publications

References 34 publications

Erythrina excelsaexhibits estrogenic effectsin vivoandin vitroand is cytotoxic on breast and colon cancer cell lines

Erythrina excelsaexhibits estrogenic effectsin vivoandin vitroand is cytotoxic on breast and colon cancer cell lines

Fenugreek seeds estrogenic activity in ovariectomized female rats

Preparatory work to support the risk assessment for peri‐ and postmenopausal women taking food supplements containing isolated isoflavones

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