Do diethyl phthalate (DEP) and di-2-ethylhexyl phthalate (DEHP) influence the metabolic syndrome parameters? Pilot study

Abstract

The study objective was to determine if the healthy participants were exposed to diethyl phthalate (DEP) and di (2-ethylhexyl) phthalate (DEHP) and if this exposure could be linked to the development of metabolic syndrome. The study included 103 healthy volunteers of similar age with normal BMI values, waist circumference, total cholesterol, HDL, LDL, and triglycerides. DEP and DEHP were measured in the morning urine samples to detect monoethyl phthalate (MEP) and mono-2-ethylhexyl phthalate (MEHP). Two phthalate groups and a control group were formed. Both MEP group and control group had similar results. The correlations between MEP and the measured parameters were insignificant. The correlation between the MEHP group and the age was significantly negative, but between the MHEP group and the waist circumference the correlation was significantly positive. Lipids and lipoproteins were within the reference values and equal in both groups. The significant negative correlation was observed only between MEHP and HDL. Our population is exposed to DEP and DEHP. There was only a significant correlation between DEHP and the observed metabolic syndrome components. Its negative impact was higher as the participants were younger.

Exposure to endocrine-disrupting chemicals and anthropometric measures of obesity: a systematic review and meta-analysis

“…A total of 5059 articles were identified; 108 abstracts were selected for full assessment; and 73 studies met our inclusion criteria (figure 1). Thirty studies were conducted in the USA, 17 in Europe, [47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63] 22 in Asia, 2 in Latin America, 86 87 1 in Africa 88 and 1 in Canada. 89 In 72 studies, the anthropometric measures of obesity were assessed by trained health professionals, and in one study, weight and height were self-reported.…”

Lactobacillus gasseri CCFM1255 promotes peripheral estrogen synthesis in ovariectomized rats by modulating the gut microbiome and serum metabolome

“…Therefore, we investigated the process of androgen-to-estrogen conversion in adipose tissue. The orientation of steroid biosynthetic pathways in adipose tissue depends on the relative expression or activity of steroid-derived enzymes [20]. We observed that the expression and concentration of CYP19 were upregulated in adipose tissue, which implies that more estrogen was being produced.…”

“…Classic steroidogenic tissues such as ovaries and adrenal glands synthesise steroid hormones de novo from cholesterol [20]. The process consists of the following steps.…”

The 21st century - the role of the pharmacist in the healthcare

“…Among EDCs are genistein, daidzein, bisphenol A (BPA), phthalates, perfluorooctan acid (PFOA), perfluorooctan sulfonates (PFOS), polychlorinated biphenyls (PCB) and polybromated biphenyls (PBB). Based on novel literature data EDCs have negative effect on human health even in minimal concentrations and are connected not only with the disruption of the endocrine function, but also with noninfectious diseases such as obesity, diabetes mellitus type 2, cardiovascular diseases, metabolic syndrome, as well as the influence on the reproductive health of men and women, influence on pregnancy development, formation of the fetus and fetal development and physiological growth and development of children and adolescents [38,39]. Pharmacist as one of the most available healthcare professionals has direct communication with the public, enjoys the public's trust, has the knowledge and opportunity to give professional information about the harmful effects of various anthropogenic pollutants especially endocrine disrupting chemicals [40].…”