Background: Musculoskeletal disorders (MSD) are one of the most common occupational hazards associated with wide ranges of occupations. Inappropriate posture may increase fatigue, decrease efficiency, and eventually lead to injuries. Aim: The purpose was to assess the Ergonomic risk level in Medicine and Dentistry, which may contribute to the manifestation of musculoskeletal disorders (MSD). Methods and Materials: A cross-sectional, descriptive study in which a self-administered questionnaire (Standardized Nordic questionnaire) was used to access the relationship between anthropometric data and the risk of work-related musculoskeletal disorders (WRMDs) among the Dental and Medical professionals. A self-reported questionnaire was distributed to a random sample of 300 professionals. The recorded data were analyzed with SPSS 21. p-value < 0.05 was considered to be statistically significant. Results: A total of 257 questionnaires were completed and returned. Of the respondents, 141 (54.8%) were males, and 116 (45.1%) were females. The mean age of respondents was 33 with SD 6.01. Prevalence of MSD during the past six months was lower back among both Dental and Medical professionals, 36.5% and 30.1% respectively. Results were statistically significant done. Conclusion: The results suggested that the prevalence of musculoskeletal symptoms among Dentists was high. MSD remains a major occupational health problem for both professionals with the most prevalent issue of the lower back and pain neck. It is essential for promoting the occupational health and prevention programs regarding Ergonomic postures which must be acquired by the Medical and Dental profession during their clinical practices.