Incontestable epidemiological trends show that, for the foreseeable future, mortality and morbidity will be dominated by an escalation in chronic lifestyle-related diseases. Exercise training (ET) elicits a wide range of health benefits that improve the health and well-being of individuals with chronic disease, 1 and the 'exercise pill' is a wonder drug that has the power to benefit the whole body system.2 ET has very few contraindications or adverse effects 3 and regular exercise has been shown to be as effective as most medically prescribed drugs [4][5][6][7] in reducing the death rate from the major cardiovascular diseases (CVDs). The more of the exercise pill you take, the healthier you will be.Today, several guidelines and meta-analyses are available, [7][8][9][10][11][12][13] and ET can be prescribed in CVD patients 14 in an individual approach; thus, after careful examination, ET should be prescribed in all CVD patients. Nonetheless, a real one-size-fits-all approach is not available, and this might contribute to underutilisation of exercise-based cardiac rehabilitation.3,6 ET prescription in different combinations according to the severity and type of CVD, risk factors and comorbidity coexistence, with different goals to be accomplished, is needed in order to tackle real-life encounters and to meet their exigencies. The European Association of Preventive Cardiology EXPERT (EXercise Prescription in Everyday practice and Rehabilitative Training) tool might help: Hansen and his group should be congratulated for creating this instrument that aims to optimise exercise prescription in all CVD patients. 15 In 2013, more than 30 ET experts (the EXPERT working group) agreed to collaborate, and they derived data for different CVD diseases, risk factors and comorbidities based on guidelines and expert opinions in order to construct an algorithm. The included CVDs in this flow chart were: (a) angina pectoris; (b) coronary artery disease (CAD) with recent coronary artery bypass graft; (c) CAD with recent percutaneous coronary intervention; (d) CAD with acute myocardial infarction; (e) heart failure (HF) with lowered left ventricular ejection fraction; (f) HF with preserved left ventricular ejection fraction; (g) peripheral artery disease; (h) pacemaker/implantable cardioverter defibrillator; (i) assist devices; (j) cardiac transplantation; (k) valve surgery without coronary artery bypass graft; and (l) congenital heart disease. CVD risk factors involved were: (a) hypertension; (b) dyslipidaemia; (c) insulin resistance/type 2 diabetes; (d) type 1 diabetes; and (e) obesity. Finally, exercise modifiers and factors/chronic diseases that significantly affect the content of rehabilitation intervention were considered, such as: (a) cardiac resynchronisation therapy for HF patients with reduced left ventricular ejection fraction; (b) pulmonary hypertension; (c) chronic lung disease; and (d) renal failure and sarcopenia/frailty.
15,16The EXPERT algorithm was proposed to support prescription, as it automatically provides an ex...