Do chondroitin sulfates with different structures have different activities on chondrocytes and macrophages?

Cunha, André Luiz da; Aguiar, Jair Adriano Kopke de; Silva, Flávio S. Corrêa da; Michelacci, Yára M.

doi:10.1016/j.ijbiomac.2017.05.123

Cited by 35 publications

(30 citation statements)

References 48 publications

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“…It has been reported that structurally diverse CS preparations significantly reduced the liberation of several proinflammatory molecules from macrophages that had been stimulated with lipopolysaccharide (LPS) . However, among those preparations, C‐6‐S inhibited the broadest spectrum of inflammatory mediators . Thus, C‐6‐S, which gradually accumulates in the tumor niche, can affect the secretory profile of the resident macrophages there (Fig.…”

Section: The Role Of C‐6‐s In the Tumor Nichementioning

confidence: 97%

“…However, several in vitro and in vivo studies have reported that in various cells that were simultaneously exposed to inflammatory stimuli and CS, the translocation of NF‐κB from the cytosol to the nucleus was markedly reduced compared to that observed in the only proinflammatorily activated cells . Moreover, it has been reported that CS with a high level of 6‐ O ‐sulfation can inhibit the NF‐κB activation in bone marrow macrophages more effectively than the GAG variant with a high level of 4‐ O ‐sulfation . In addition to native CS, unsaturated 6‐ O ‐sulfated CS disaccharides are also able to exert this inhibitory effect on NF‐κB .…”

Section: The Role Of C‐6‐s In the Tumor Nichementioning

confidence: 99%

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The dual role of the glycosaminoglycan chondroitin‐6‐sulfate in the development, progression and metastasis of cancer

et al. 2019

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The remarkable structural heterogeneity of chondroitin sulfate (CS) and dermatan sulfate (DS) generates biological information that can be unique to each of these glycosaminoglycans (GAGs), and changes in their composition are translated into alterations in the binding profiles of these molecules. CS/DS can bind to various cytokines and growth factors, cell surface receptors, adhesion molecules, enzymes and fibrillar glycoproteins of the extracellular matrix, thereby influencing both cell behavior and the biomechanical and biochemical properties of the matrix. In this review, we summarize the current knowledge concerning CS/DS metabolism in the human cancer stroma. The remodeling of the GAG profile in the tumor niche is manifested as a substantial increase in the CS content and a gradual decrease in the proportion between DS and CS. Furthermore, the composition of CS and DS is also affected, which results in a substantial increase in the 6‐O‐sulfated and/or unsulfated disaccharide content, which is concomitant with a decrease in the 4‐O‐sulfation level. Here, we discuss the possible impact of alterations in the CS/DS sulfation pattern on the binding capacity and specificity of these GAGs. Moreover, we propose potential consequences of the stromal accumulation of chondroitin‐6‐sulfate for the progression and metastasis of cancer.

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Section: The Role Of C‐6‐s In the Tumor Nichementioning

confidence: 97%

Section: The Role Of C‐6‐s In the Tumor Nichementioning

confidence: 99%

The dual role of the glycosaminoglycan chondroitin‐6‐sulfate in the development, progression and metastasis of cancer

et al. 2019

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“…nitric oxide synthase 2, and prostaglandin E2 synthase (36,37). Further, CS blocks lipopolysaccharide (LPS) binding to CD44 on rat bone marrow-derived macrophages to inhibit the LPS/CD44/NF-κB pathway (38).…”

Section: The Role Of Chondroitin Sulfate In Macrophagesmentioning

confidence: 99%

“…In contrast, CSC attenuates the inflammatory response in macrophages via suppression of NF-κB nuclear translocation (40). Moreover, CSA or CSC inhibited the LPS-induced expression of TNF-α, IL-1β, IL-6, and nitric oxide (NO) on bone marrow-derived macrophages (36). The functions of the CS sulfated structures on macrophages are still in argument.…”

Section: The Role Of Chondroitin Sulfate In Macrophagesmentioning

confidence: 99%

Regulation of Macrophage and Dendritic Cell Function by Chondroitin Sulfate in Innate to Antigen-Specific Adaptive Immunity

Hatano

Watanabe

2020

Front. Immunol.

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Chondroitin sulfate (CS), a type of glycosaminoglycan (GAG), is a linear acidic polysaccharide comprised of repeating disaccharides, modified with sulfate groups at various positions. Except for hyaluronan (HA), GAGs are covalently bound to core proteins, forming proteoglycans (PGs). With highly negative charges, GAGs interact with a variety of physiologically active molecules, including cytokines, chemokines, and growth factors, and control cell behavior during development and in the progression of diseases, including cancer, infections, and inflammation. Heparan sulfate (HS), another type of GAG, and HA are well reported as regulators for leukocyte migration at sites of inflammation. There have been many reports on the regulation of immune cell function by HS and HA; however, regulation of immune cells by CS has not yet been fully understood. This article focuses on the regulatory function of CS in antigen-presenting cells, including macrophages and dendritic cells, and refers to CSPGs, such as versican and biglycan, and the cell surface proteoglycan, syndecan.

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“…Обнаружена зависимость противовоспалительных свойств ХС от его структурного состава, который, в свою очередь, зависит от вида животного сырья, используемого для производства ХС, -бычьи хрящи, трахеи свиней, кур или ткани ската [41]. Изучение гипотензивной активности ХС произведенного из бычьих и куриных хрящей, показало, что бычий ХС обладает более быстрым, но кратковременным действием относительно куриного ХС, Обзоры литературы гипотензивная активность куриного ХС была более выраженной [42].…”

Section: фармакологическая активность гликозаминогликановunclassified

Chondroitin sodium sulfate – impurities and standardization problems (literature review)

Komarova¹,

Chernova

Касумова

et al. 2019

Rossijskij bioterapevtičeskij žurnal

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Modern research in the field of chondroitin sulfate chemical composition is considered. Clinical efficiency and safety are shown to depend on the nature and quality of the raw material used, ways of its technological processing and the degree of purification. The composition of chemical compounds (CC) variable is stated to represent the mixture of 2 main isomeric forms: chondroitin 4-sulfate and chondroitin 6-sulfate. In the animal tissue chondroitin 4-sulfate dominates, the content of which is 70 %; the content of chondroitin 6-sulfate is 30 %. The cartilages of sharks and other hydrobionts have got low content of chondroitin 4-sulfate (10 %) and chondroitin 6-sulfate 80 %. Complex polymeric structure and instability of CC composition make the problem of drug standardization on its basis complicated. The impurities encountered in substances are considered. The impurities are divided into several groups: related impurities, technological or mechanical ones uncharacteristic of CC. Comparative analysis of requirements for raw material from the point of view of normative documentation of different countries is carried out and their considerable difference is detected. It has been shown that for raising pharmacological activity the producer of drugs must take into account all the parameters of CC including the structural composition, molecular weight and presence of impurities.

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Do chondroitin sulfates with different structures have different activities on chondrocytes and macrophages?

Cited by 35 publications

References 48 publications

The dual role of the glycosaminoglycan chondroitin‐6‐sulfate in the development, progression and metastasis of cancer

The dual role of the glycosaminoglycan chondroitin‐6‐sulfate in the development, progression and metastasis of cancer

Regulation of Macrophage and Dendritic Cell Function by Chondroitin Sulfate in Innate to Antigen-Specific Adaptive Immunity

Chondroitin sodium sulfate – impurities and standardization problems (literature review)

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