Do Children With Gastroesophageal Reflux Become Adults With Gastroesophageal Reflux? What Is the Role of Acid Suppression in Children?

Boyle, JT; J, Co; Davidson, Geoff; Freston, J. W.; Nelson, Suzanne; Tolia,; Sl, Werlin

doi:10.1097/00005176-200311001-00013

Cited by 5 publications

(1 citation statement)

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“…As recently described by Ward and Kearns, 8 ligand binding (e.g., histamine, gastrin, or acetylcholine) to this acid proton pump creates a 1 million–fold gradient in H + concentration from inside the parietal cell to the gastric lumen, in return for inward transport of K + . Activation of H + ‐K + ‐ATPase is the common final pathway for gastric acid secretion in humans of all ages, 9 , 10 , 11 as reflected by the fact that neonates of 24 weeks gestational age can secrete enough acid to lower the intragastric pH to <4 12 . It is also the pathway that is the mechanistic “target” for PPIs.…”

Section: The Proton Pump Inhibitorsmentioning

confidence: 99%

Failure of Proton Pump Inhibitors to Treat GERD in Neonates and Infants: A Question of Drug, Diagnosis, or Design

Shakhnovich

Ward

Kearns

2012

Clin Pharmacol Ther

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The only time you don't fail is the last time you try anything-and it works. " -William StrongDistressful symptoms associated with gastroesophageal reflux constitute a clinical description of gastroesophageal reflux disease, a pathologic condition commonly treated with proton pump inhibitors (PPIs). Despite their pervasive use in neonates and infants, PPIs have not been approved for gastroesophageal reflux disease treatment in this population. This creates a therapeutic conundrum: namely, whether to institute PPI treatment based on knowledge and experience or to withhold it consequent to absence of labeling for young infants.

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