Do bromadiolone treatments to control grassland water voles (<i>Arvicola scherman</i>) affect small mustelid abundance?

Fernandez-de-Simon, Javier; Cœurdassier, Michaël; Couval, Geoffroy; Fourel, Isabelle; Giraudoux, Patrick

doi:10.1002/ps.5194

Cited by 21 publications

(16 citation statements)

References 42 publications

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“…Water voles were trapped in two French regions of mid-mountain areas; i/ on the second Plateau of the Jura Mountains in Franche-Comté (Eastern France) from 9 different sites-and ii/ in the Massif Central Mountains from twenty one different sites i.e., eight sites in Puy-de-Dôme department and thirteen sites in Cantal department (thirteen sites) (Figure 1). Water voles (n=100) trapped in Franche-Comté (see Fernandez-de-Simon et al, 2019) were only used for Vkorc1 sequencing. These animals were obtained in 2016 from sites where bromadiolone selection pressure was either absent (Site1, 2, 4, 5, 9), medium (Site 7 and 8) or high (Site 3 and 6) (Fernandez-De-Simon et al, 2019).…”

Section: 2animals and Trapping Sitesmentioning

confidence: 99%

Seasonal diet-based resistance to anticoagulant rodenticides in the fossorial water vole (Arvicola amphibius)

Khalil

Barbier²,

Fafournoux³

et al. 2021

Environmental Research

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Section: 2animals and Trapping Sitesmentioning

confidence: 99%

Seasonal diet-based resistance to anticoagulant rodenticides in the fossorial water vole (Arvicola amphibius)

Khalil

Barbier²,

Fafournoux³

et al. 2021

Environmental Research

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“…by feeding on poisoned prey. Several studies provided experimental evidence that ARs can cause the death of mustelides by secondary exposure ( Mustela nivalis , Warfarin: [46]; Mustela erminea , Bromadiolone: [47,68]) and have suggested bromadiolone to cause mustelid decline from abundances in field, however, without analyzing AR residues. Rodent control with brodifacoum in New Zealand resulted in the death of Mustela erminea and M .…”

Section: Discussionmentioning

confidence: 99%

The potential of VKORC1 polymorphisms in Mustelidae for evolving anticoagulant resistance through selection along the food chain

et al. 2019

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In response to strong selection, new mutations can arise quickly and sweep through populations, particularly, if survival and reproduction depend on certain allele copies for adaptation to rapidly changing environments, like resistance against deadly diseases or strong toxins. Since the 1950s, resistance to anticoagulant rodenticides in several rodents has emerged through single nucleotide mutations in the vitamin-K-epoxid-reductase-complex-subunit-1 (VKORC1) gene, often located in its exon 3. Detection of high prevalence and concentrations of anticoagulant rodenticides in non-target vertebrates, including carnivorous Mustelidae, let us assume that secondary exposure by feeding on poisoned prey may also cause selection along the food chain and we hypothesized that VKORC1-based resistance might also have evolved in rodents’ predators. Using newly-developed mustelid-specific primers for direct sequencing of genomic DNA, we studied VKORC1-DNA-polymorphisms in 115 mustelids of five species ( Martes martes , M . foina , Mustela nivalis , M . erminea , M . putorius ), obtained from northern Denmark, yielding six sites with nonsynonymous and several synonymous amino acid polymorphisms in exon 3. Comparison of these VKORC1-genotypes with hepatic rodenticide residues (obtained by HPLC combined with fluorescence or mass spectrometry) in 83 individuals (except M . martes ), using generalized linear models, suggested that anticoagulant levels depended on species and specific polymorphisms. Although most VKORC-1 polymorphisms may present standing genetic variation, some are situated in resistance-mediating membrane parts of the VKORC1-encoded protein, and might be a result of selection due to exposure to anticoagulant poisons. Our new molecular markers might allow detecting indirect effects of anticoagulant rodenticides on rodent predator populations in the future.

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“…Modelling exercises suggest that the transfer of ARs to mammalian predators is mainly driven by use patterns 32 . For some non‐target species adverse population effects have been suggested such as in non‐target rodents, 33 American badger ( Taxidea taxus L.), 34 red fox ( Vulpes vulpes L.) 35 and mustelids 36 …”

Section: Introductionmentioning

confidence: 99%

Baiting location affects anticoagulant rodenticide exposure of non‐target small mammals on farms

Walther

Geduhn

Schenke

et al. 2020

Pest Management Science

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BACKGROUND Commensal rodents such as Norway rats (Rattus norvegicus Berk.), black rats (R. rattus L.) and house mice (Mus musculus L.) damage stored produce and infrastructure, cause hygienic problems and transmit zoonotic pathogens to humans. The management of commensal rodents relies mainly on the use of anticoagulant rodenticides (ARs). ARs are persistent and bio‐accumulative, which can cause exposure of non‐target species. We compared the baiting strategies to use brodifacoum (BR) in bait boxes indoors only versus in and around buildings in replicated field trials at livestock farms to assess resulting BR residues in non‐target small mammals. RESULTS When bait was used indoors only, the percentage of trapped non‐target small mammals with BR residues as well as BR concentration in liver tissue was about 50% lower in comparison to bait application in and around buildings. These effects occurred in murid rodents and shrews but not in voles that were generally only mildly exposed. During the baiting period, BR concentration in murids was stable but decreased by about 50% in shrews. CONCLUSION Restricting the application of BR bait to indoors only can reduce exposure of non‐target species. The positive effect of this baiting strategy on non‐target species needs to be balanced with the need for an effective pest rodent management within a reasonable time. More research is needed to clarify which management approaches strike this balance best.

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Do bromadiolone treatments to control grassland water voles (Arvicola scherman) affect small mustelid abundance?

Cited by 21 publications

References 42 publications

Seasonal diet-based resistance to anticoagulant rodenticides in the fossorial water vole (Arvicola amphibius)

Seasonal diet-based resistance to anticoagulant rodenticides in the fossorial water vole (Arvicola amphibius)

The potential of VKORC1 polymorphisms in Mustelidae for evolving anticoagulant resistance through selection along the food chain

Baiting location affects anticoagulant rodenticide exposure of non‐target small mammals on farms

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