Do Bradykinesia and Tremor Interfere in Voluntary Movement of Essential Tremor Patients? Preliminary Findings

Goubault, Étienne; Nguyen, Huan Buu; Ayachi, Fouaz Sofiane; Bogard, Sarah; Duval, Christian

doi:10.7916/d822319x

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…Grasping movements in ET were kinematically characterized by slowness, particularly in patients with kinetic tremor, possibly as a compensatory mechanism for the subclinical dysmetria of these patients, in keeping with the well-known cerebellar impairment of these patients [109]. Accordingly, in some studies, slowed velocity, irregular rhythm, and impaired dexterity during rapid alternating movements of the upper limbs have also been described [24,26,27,[110][111][112][113].…”

Section: Ul Movementsmentioning

confidence: 72%

“…Clinical studies indicate that patients with cerebellar lesions may have movement slowness in both the preparation and execution phases [114][115][116][117][118]. In patients with cerebellar disease, neurophysiological studies confirmed prolonged RTs [38,89,119,120] and bradykinesia when performing simple [39,[113][114][115][116][117][118][121][122][123][124][125] or more complex arm movements [38,40,120,126]. A kinematic analysis performed in patients with acute cerebellar stroke showed that nearly 70% of cases exhibited movement slowness during goal-directed upper limb movements [127].…”

Section: B R Adykine S Ia In Cereb Ell Ar Disorder Smentioning

confidence: 99%

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Emerging concepts on bradykinesia in non‐parkinsonian conditions

Paparella

Fasano

Hallett

et al. 2021

Euro J of Neurology

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Background and purpose Bradykinesia is one of the cardinal motor symptoms of Parkinson's disease. However, clinical and experimental studies indicate that bradykinesia may also be observed in various neurological diseases not primarily characterized by parkinsonism. These conditions include hyperkinetic movement disorders, such as dystonia, chorea, and essential tremor. Bradykinesia may also be observed in patients with neurological conditions that are not seen as "movement disorders," including those characterized by the involvement of the cerebellum and corticospinal system, dementia, multiple sclerosis, and psychiatric disorders. Methods We reviewed clinical reports and experimental studies on bradykinesia in non‐parkinsonian conditions and discussed the major findings. Results Bradykinesia is a common motor abnormality in non‐parkinsonian conditions. From a pathophysiological standpoint, bradykinesia in neurological conditions not primarily characterized by parkinsonism may be explained by brain network dysfunction. Conclusion In addition to the pathophysiological implications, the present paper highlights important terminological issues and the need for a new, more accurate, and more widely used definition of bradykinesia in the context of movement disorders and other neurological conditions.

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Section: Ul Movementsmentioning

confidence: 72%

Section: B R Adykine S Ia In Cereb Ell Ar Disorder Smentioning

confidence: 99%

Emerging concepts on bradykinesia in non‐parkinsonian conditions

Paparella

Fasano

Hallett

et al. 2021

Euro J of Neurology

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“…Among the motor features, we found that bradykinesia, rigidity, and postural abnormality were more common in patients with ET-PD than ET. Bradykinesia is the cardinal motor symptom in PD, which has also been reported in ET (4,28). Several studies have shown that cerebellar dysfunction is involved in the pathophysiology of movement slowness in ET (4,29).…”

Section: Discussionmentioning

confidence: 91%

Clinical Characteristics and Electrophysiological Biomarkers of Parkinson's Disease Developed From Essential Tremor

et al. 2020

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Background and Objective: Parkinson's disease developed from essential tremor (ET-PD) is a distinct clinical syndrome that is different from essential tremor (ET) and Parkinson's disease (PD). There is currently a lack of research on ET-PD. Tremor characteristics (amplitude and frequency) are primary quantitative indexes for diagnosing and monitoring of tremors. In this study, we aimed to explore specific clinical and electrophysiological biomarkers for the identification of ET-PD. Methods:The study included patients with ET-PD (n = 22), ET (n = 42), and tremor-dominant PD (t-PD, n = 47). We collected demographic data, clinical characteristics (including motor and non-motor symptoms), and tremor analysis. The frequency, amplitude, contracting patterns of resting tremor and postural tremor were collected. The analysis of ET-PD and ET/t-PD was compared. The receiver operating characteristic (ROC) curve was used to analyze the electrophysiological features in distinguishing ET-PD from ET or t-PD.Results: Compared with ET, hyposmia, bradykinesia, rigidity, postural abnormality, and resting tremor were more common in the ET-PD group (P = 0.01, 0.003, 0.001, 0.001, 0.019, respectively). The postural tremor frequencies of the head, upper limbs, and lower limbs were significantly lower in the ET-PD than in the ET (P = 0.007, 0.003, 0.035, respectively), which were the most appropriate variables for distinguishing ET-PD from ET (AUC: 0.775, 0.727, and 0.701, respectively). Compared with t-PD, bradykinesia, rigidity, postural abnormality (both P < 0.001), and resting tremor (P = 0.024) were less common in the ET-PD. The postural tremor amplitudes of the head and upper limbs were significantly higher in the ET-PD than in the t-PD (P = 0.022, 0.001, respectively), which were the most appropriate variables for distinguishing ET-PD from t-PD (AUC: 0.793 and 0.716). Conclusions:Hyposmia and electrophysiological biomarkers (postural tremor frequencies and amplitudes) help early recognition of ET-PD.

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“…However, the total duration of the activity T was found to correlate very weakly ( r 2 = 0.002) with the FTM score.While there is evidence that ET patients have a degree of slowness of movement 34 – 38 , this is not captured by the FTM scale, or by other clinical rating scales for ET. Rapid alternating limb movements are performed abnormally slowly 35 – 37 , and the rhythmicity of repetitive hand movements is impaired by ET 38 . Slowness of movement in ET has, in some studies, been comparable in degree with the bradykinesia of early PD 36 .…”

Section: Discussionmentioning

confidence: 99%

Wearable sensors during drawing tasks to measure the severity of essential tremor

Ali

Arjunan

Peters

et al. 2022

Sci Rep

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Commonly used methods to assess the severity of essential tremor (ET) are based on clinical observation and lack objectivity. This study proposes the use of wearable accelerometer sensors for the quantitative assessment of ET. Acceleration data was recorded by inertial measurement unit (IMU) sensors during sketching of Archimedes spirals in 17 ET participants and 18 healthy controls. IMUs were placed at three points (dorsum of hand, posterior forearm, posterior upper arm) of each participant’s dominant arm. Movement disorder neurologists who were blinded to clinical information scored ET patients on the Fahn–Tolosa–Marin rating scale (FTM) and conducted phenotyping according to the recent Consensus Statement on the Classification of Tremors. The ratio of power spectral density of acceleration data in 4–12 Hz to 0.5–4 Hz bands and the total duration of the action were inputs to a support vector machine that was trained to classify the ET subtype. Regression analysis was performed to determine the relationship of acceleration and temporal data with the FTM scores. The results show that the sensor located on the forearm had the best classification and regression results, with accuracy of 85.71% for binary classification of ET versus control. There was a moderate to good correlation (r2 = 0.561) between FTM and a combination of power spectral density ratio and task time. However, the system could not accurately differentiate ET phenotypes according to the Consensus classification scheme. Potential applications of machine-based assessment of ET using wearable sensors include clinical trials and remote monitoring of patients.

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Do Bradykinesia and Tremor Interfere in Voluntary Movement of Essential Tremor Patients? Preliminary Findings

Cited by 7 publications

References 25 publications

Emerging concepts on bradykinesia in non‐parkinsonian conditions

Emerging concepts on bradykinesia in non‐parkinsonian conditions

Clinical Characteristics and Electrophysiological Biomarkers of Parkinson's Disease Developed From Essential Tremor

Wearable sensors during drawing tasks to measure the severity of essential tremor

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