Do blood levels of neuron‐specific enolase and S‐100 protein reflect cognitive dysfunction after coronary artery bypass?

Rasmussen, Lars S.; Christiansen, Michael; Hansen, Per Brinch; Møller, Jesper M.

doi:10.1034/j.1399-6576.1999.430502.x

Cited by 94 publications

(99 citation statements)

References 20 publications

(25 reference statements)

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“…Martens et al (27) described that S100 correlated significantly with bypass time, cross clamp time and lowest temperature during CPB, probably due to the use of non-pulsatile CPB. Rasmussen et al (28) reported that S100 at 24 hours correlated well with the duration of CPB, but not with measures of cognitive dysfunction. From the present study, we may find two peaks of serum S100 protein.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of cerebral injury in cardiac surgery

Yuan¹

2014

Anadolu Kardiyol Derg

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The present study aims to reveal the changing patterns of cerebral biomarkers and the underlying predictive factors as a consequence of cardiac surgery. Literature retrieval of articles on S100 and S100B of recent 20 years were made in the MEDLINE database, Highwire Press and Google search. Quantitative data of S100 and S100B along with neuron-specific enolase were carefully screened, collected and statistically analyzed. The biomarkers appeared earlier and lasted longer in the cerebrospinal fluid than in the serum. All three biomarkers exhibited a similar kinetic trend in the bloodstream, reaching a peak value at the end of cardiopulmonary bypass (CPB). In adults, serum biomarkers may recover to normal earlier than in pediatrics undergoing a cardiac surgery. The patients undergoing off-pump surgery had the minimal elevations of cerebral biomarkers comparing to all other cardiac surgeries under CPB, low core temperature and/or hypothermic circulatory arrest. In patients with pre-or postoperative neurological disorders, the biomarkers in the serum elevated even before operation and persisted longer time than those without neurological disorders. The serum concentrations of the biomarkers showed direct correlation with CPB duration and core temperature. Cardiac operations may lead to cerebral damage and blood-brain barrier changes, as a consequence of CPB and low core temperature. The cerebral biomarkers including S100, S100B and neuron-specific enolase may precisely reflect the cerebral damages in cardiac surgery. Attention has to be paid to the attenuations of cerebral damage by modifying the surgical conditions of CPB and core temperature.

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Section: Discussionmentioning

confidence: 99%

Biomarkers of cerebral injury in cardiac surgery

Yuan¹

2014

Anadolu Kardiyol Derg

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“…[50] hem S100b hem de NSE değerlerinin cerrahi süresi, perfüzyon ve kros-klemp süresinden bağımsız olduğunu bildirmişlerdir. Rasmussen ve ark.na [51] göre serum S100b düzeyindeki artış, KPB süresi ile ilişki-lidir. Gu ve ark.…”

Section: Nöron Spesifik Enolazunclassified

“…Erken dönemde (KPB'den sonra ilk 5 saat) yaş, dolaşım arresti ve KPB süresi, aort kros-klemp zamanı, ameliyat öncesi serebrovasküler hastalıklar, aort kanülasyonu sırasında oluşan emboli sayısı, ameliyat sonrası serebral komplikasyonlar ve ameliyat öncesi renal hasar; geç dönemde (KPB'den sonra 15-48 saat arası) perioperatif serebral komplikasyonlar, dolaşım arresti ve serebral perfüzyon yokluğunun süresi, çıkan aort aterosklerozu ve yenidoğanlar gibi etkenlerin etkili olduğu Hemoliz Nöron spesifik enolaz artar, S100b etkilenmez [41] Kardiyotomi aspirasyon S100b artar, nöron spesifik enolaz etkilenmez [9] Koroner arter baypas greftleme, kapak replasman cerrahisi Nöron spesifik enolaz ve S100b artar [40] Kardiyopulmoner baypas Nöron spesifik enolaz ve S100b artar [45] Aprotinin Nöron spesifik enolaz ve S100b etkilenmez [9] MgSO 4 infüzyonu S100b azalır, nöron spesifik enolaz bilinmiyor [43] Dopamin infüzyonu S100b artar, nöron spesifik enolaz bilinmiyor [43] Heparin, protamin, propofol S100b etkilenmez, nöron spesifik enolaz bilinmiyor [44] Metilprednizolon Nöron spesifik enolaz azalır, S100b bilinmiyor [45] Kardiyopulmoner baypas süresi Nöron spesifik enolaz ve S100b artar [21,47] Nöron spesifik enolaz etkilenmez [45] S100b artar [51] Off-pump koroner arter baypas greftleme S100b azalır, nöron spesifik enolaz bilinmiyor [47] Pulsatil akıma karşı nonpulsatil akım S100b etkilenmez, nöron spesifik enolaz bilinmiyor [46] S100b azalır, nöron spesifik enolaz bilinmiyor [49] Yaş S100b etkilenmez [48 Nöron spesifik enolaz ve S100b artar [21] Perfüzyon süresi S100b artar [34] S100b etkilenmez [48] Aort kros-klemp zamanı S100b etkilenmez [48] Nöron spesifik enolaz ve S100b etkilenmez [50] Nöron spesifik enolaz ve S100b artar [21] Yoğun bakımda yatış süresi, cinsiyet S100b etkilenmez, nöron spesifik enolaz bilinmiyor [48] Cerrahi süresi Nöron spesifik enolaz ve S100b etkilenmez [50] Apoe4 alleli Nöron spesifik enolaz ve S100b artar [54] düşünülmektedir. [24] Özatik ve ark.…”

Section: Nöron Spesifik Enolazunclassified

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Neurocognitive dysfunction after cardiac surgery and biochemical markers

Öztürk¹

2013

Turk Gogus Kalp Dama

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“…POCD is characterized by impairment of recent memory, concentration, language comprehension, and social integration. 1,2 This syndrome may be detected days to weeks after surgery and may even be permanent. 3 Although POCD is most frequent after cardiac surgery, the prevalence of POCD after noncardiac surgery in older patients is also significant (25% at 1 week, 10% at 3 months after surgery).…”

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confidence: 99%

Postoperative Cognitive Dysfunction in Older Patients With a History of Alcohol Abuse

&NA;

2007

Survey of Anesthesiology

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Background: Postoperative cognitive dysfunction (POCD) affects a significant number of patients and may have serious consequences for quality of life. Although POCD is most frequent after cardiac surgery, the prevalence of POCD after noncardiac surgery in older patients is also significant. The risk factors for POCD after noncardiac surgery include advanced age and preexisting cognitive impairment. Self-reported alcohol abuse is a risk factor for postoperative delirium, but its significance for long-term POCD has not been investigated. The goal of this study was to determine whether neurocognitive function is impaired after noncardiac surgery during general anesthesia in older patients with a history of alcohol abuse.Methods: Subjects aged 55 yr and older with self-reported alcohol abuse (n ‫؍‬ 28) and age-, sex-, education-matched nonalcoholic controls (n ‫؍‬ 28) were tested using a neurocognitive battery before and 2 weeks after elective surgery (n ‫؍‬ 28) or a corresponding time interval without surgery (n ‫؍‬ 28). Verbal memory, visuospatial memory, and executive functions were assessed. A neurologic examination was performed to exclude subjects with potential cerebrovascular damage.Results: Significant three-way interactions (analysis of variance) for Visual Immediate Recall, Visual Delayed Recall, Semantic Fluency, Phonemic Fluency, and the Color-Word Stroop Test implied that cognitive performance in the alcoholic group decreased after surgery more than it did in the other three groups.Conclusions: The results suggest that a history of alcohol abuse in older patients presents a risk for postoperative cognitive impairment in the domains of visuospatial abilities and executive functions that may have important implications for quality of life and health risks.

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Do blood levels of neuron‐specific enolase and S‐100 protein reflect cognitive dysfunction after coronary artery bypass?

Abstract: NSE seems to be a useful blood marker for early cognitive dysfunction after coronary artery bypass surgery.

Cited by 94 publications

References 20 publications

Biomarkers of cerebral injury in cardiac surgery

Biomarkers of cerebral injury in cardiac surgery

Neurocognitive dysfunction after cardiac surgery and biochemical markers

Postoperative Cognitive Dysfunction in Older Patients With a History of Alcohol Abuse

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