Do Bisphosphonates Slow the Progression of Aortic Stenosis?

Aksoy, Olcay; Cam, Akin; Goel, Sachin S.; Houghtaling, Penny L.; Williams, Sarah; Ruiz-Rodriguez, Ernesto; Menon, Venu; Kapadia, Samir; Tuzcu, E. Murat; Blackstone, Eugene H.; Griffin, Brian P.

doi:10.1016/j.jacc.2012.01.024

Cited by 49 publications

(22 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect of osteoporosis therapy has been investigated because of an association between aortic valve calcification and low skeletal bone mineral density (Aksoy et al, 2005). Several small observational studies demonstrated a possible link between use of bisphosphonates and slowing of AVS progression (Skolnick et al, 2009;Sterbakova et al, 2010;Innasimuthu and Katz, 2011), although such beneficial effects may be not remarkable in older women (Aksoy et al, 2012). Taken together, prospective randomized clinical studies are certainly needed to evaluate the role of regulation of calcium and phosphate metabolism for preventing progression of CAVD especially at its early stage.…”

Section: Discussionmentioning

confidence: 99%

Mineral metabolism disturbances are associated with the presence and severity of calcific aortic valve disease

Yang

Zhao

Fang

et al. 2015

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Abstract:Objective: We investigated whether disturbance of calcium and phosphate metabolism is associated with the presence and severity of calcific aortic valve disease (CAVD) in patients with normal or mildly impaired renal function. Methods: We measured serum levels of calcium, phosphate, alkaline phosphatase (AKP), intact parathyroid hormone (iPTH), 25-hydroxyvitamin D (25-OHD), and biomarkers of bone turnover in 260 consecutive patients with normal or mildly impaired renal function and aortic valve sclerosis (AVSc) (n=164) or stenosis (AVS) (n=96) and in 164 age-and gender-matched controls. Logistic regression models were used to determine the association of mineral metabolism parameters with the presence and severity of CAVD. Results: Stepwise increases were observed in serum levels of calcium, phosphate, AKP, and iPTH from the control group to patients with AVS, and with reverse changes for 25-OHD levels (all P<0.001). Similarly, osteocalcin, procollagen I N-terminal peptide, and β-isomerized type I collagen C-telopeptide breakdown products were significantly increased stepwise from the control group to patients with AVS (all P<0.001). In patients with AVS, serum levels of iPTH were positively, in contrast 25-OHD levels were negatively, related to trans-aortic peak flow velocity and mean pressure gradient. After adjusting for relevant confounding variables, increased serum levels of calcium, phosphate, AKP, and iPTH and reduced serum levels of 25-OHD were independently associated with the presence and severity of CAVD. Conclusions: This study suggests an association between mineral metabolism disturbance and the presence and severity of CAVD in patients with normal or mildly impaired renal function. Abnormal bone turnover may be a potential mechanism.

show abstract

Section: Discussionmentioning

confidence: 99%

Mineral metabolism disturbances are associated with the presence and severity of calcific aortic valve disease

Yang

Zhao

Fang

et al. 2015

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

show abstract

“…Progression of degenerative aortic valve to AS is a multifactorial and complicated process that differs among individuals with respect to time course. 14 and bisphosphonates, 15 have been administered in attempts to prevent progression of AS. However, none of those trials could prove any significant effects.…”

Section: Can We Predict or Prevent Progression Of Aortic Stenosis?mentioning

confidence: 99%

Can We Predict or Prevent Progression of Aortic Stenosis?

Daimon

2015

Circ J

View full text Add to dashboard Cite

“…Furthermore, our findings add to the evidence for a reciprocal regulation of bone metabolism and calcification of the aortic valve. It seems less likely that valve calcification is a secondary phenomenon of catabolic bone metabolism resulting in osteoporosis given that for instance bisphosphonate treatment did not have relevant impact on the progression of aortic stenosis in a retrospective analysis [8]. More plausibly, common mechanisms underlie both osteoporosis and calcific aortic disease.…”

mentioning

confidence: 98%

Inverse association between bone mineral density and risk of aortic stenosis in men and women in EPIC–Norfolk prospective study

Pfister

Michels

Sharp

et al. 2015

International Journal of Cardiology

View full text Add to dashboard Cite

Do Bisphosphonates Slow the Progression of Aortic Stenosis?

Abstract: In this retrospective analysis of older female patients, bisphosphonates do not have a significant impact on the hemodynamic or clinical progression of aortic stenosis.

Cited by 49 publications

References 35 publications

Mineral metabolism disturbances are associated with the presence and severity of calcific aortic valve disease

Mineral metabolism disturbances are associated with the presence and severity of calcific aortic valve disease

Can We Predict or Prevent Progression of Aortic Stenosis?

Inverse association between bone mineral density and risk of aortic stenosis in men and women in EPIC–Norfolk prospective study

Contact Info

Product

Resources

About